Potential of Human Embryonic Stem Cells in Cartilage Tissue Engineering and Regenerative Medicine

2010 ◽  
Vol 7 (3) ◽  
pp. 544-559 ◽  
Author(s):  
Wei Seong Toh ◽  
Eng Hin Lee ◽  
Tong Cao
Keyword(s):  
Tissue Engineering ◽  
Stem Cells ◽  
Embryonic Stem Cells ◽  
Regenerative Medicine ◽  
Human Embryonic Stem Cells ◽  
Cartilage Tissue Engineering ◽  
Embryonic Stem ◽  
Cartilage Tissue

scholarly journals Modified methods for efficiently differentiating human embryonic stem cells into chondrocyte-like cells

2017 ◽  
Vol 71 (1) ◽  
pp. 0-0 ◽  
Author(s):  
Wiktoria Maria Suchorska ◽  
Ewelina Augustyniak ◽  
Magdalena Richter ◽  
Magdalena Łukjanow ◽  
Violetta Filas ◽  
...  
Keyword(s):  
Stem Cells ◽  
Embryonic Stem Cells ◽  
Human Embryonic Stem Cells ◽  
Cartilage Tissue Engineering ◽  
Embryonic Stem ◽  
Cartilage Regeneration ◽  
Cell Types ◽  
Joint Disease ◽  
Cartilage Tissue ◽  
Human Articular Cartilage

Human articular cartilage has a poor regenerative capacity. This often results in the serious joint disease- osteoarthritis (OA) that is characterized by cartilage degradation. An inability to self-repair provided extensive studies on AC regeneration. The cell-based cartilage tissue engineering is a promising approach for cartilage regeneration. So far, numerous cell types have been reported to show chondrogenic potential, among others human embryonic stem cells (hESCs).

Regenerative Medicine: Applications and Development in Urology

2007 ◽  
Vol 74 (4) ◽  
pp. 197-205
Author(s):  
F. Pinto ◽  
A. Calarco ◽  
A. Brescia ◽  
E. Sacco ◽  
A. D'addessi ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Stem Cells ◽  
Embryonic Stem Cells ◽  
Regenerative Medicine ◽  
Cell Transplantation ◽  
Materials Science ◽  
Experimental Studies ◽  
Embryonic Stem ◽  
Human Embryos ◽  
Engineering Applications

Purpose Congenital abnormalities and acquired disorders can lead to organ damage and loss. Nowadays, transplantation represents the only effective treatment option. However, there is a marked decrease in the number of organ donors, which is even yearly worsening due to the population aging. The regenerative medicine represents a realistic option that allows to restore and maintain the normal functions of tissues and organs. This article reviews the principles of regenerative medicine and the recent advances with regard to its application to the genitourinary tract. Recent findings The field of regenerative medicine involves different areas of technology, such as tissue engineering, stem cells and cloning. Tissue engineering involves the field of cell transplantation, materials science and engineering in order to create functional replacement tissues. Stem cells and cloning permit the extraction of pluripotent, embryonic stem cells offering a potentially limitless source of cells for tissue engineering applications. Most current strategies for tissue engineering depend upon a sample of autologous cells from the patient's diseased organ. Biopsies from patients with extensive end-stage organ failure, however, may not yield enough normal cells. In these situations, stem cells are envisaged as being an alternative source. Stem cells can be derived from discarded human embryos (human embryonic stem cells), from fetal tissue or from adult sources (bone marrow, fat, skin). Therapeutic cloning offers a potentially limitless source of cells for tissue engineering applications. Regenerative medicine and tissue engineering scientists have increasingly applied the principles of cell transplantation, materials science and bioengineering to construct biological substitutes that will restore and maintain normal function in urological diseased and injured tissues such as kidney, ureter, bladder, urethra and penis. Conclusions Regenerative medicine offers several applications in acquired and congenital genitourinary diseases. Tissue engineering, stem cells and, mostly, cloning have been applied in experimental studies with excellent results. Few preliminary human applications have been developed with promising results.

scholarly journals Tissue Engineering of Vascularized Cardiac Muscle From Human Embryonic Stem Cells

2007 ◽  
Vol 100 (2) ◽  
pp. 263-272 ◽  
Author(s):  
Oren Caspi ◽  
Ayelet Lesman ◽  
Yaara Basevitch ◽  
Amira Gepstein ◽  
Gil Arbel ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Stem Cells ◽  
Embryonic Stem Cells ◽  
Cardiac Muscle ◽  
Human Embryonic Stem Cells ◽  
Embryonic Stem
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