scholarly journals Head-to-head comparison of FNA cytology vs. calcitonin measurement in FNA washout fluids (FNA-CT) to diagnose medullary thyroid carcinoma. A systematic review and meta-analysis

Endocrine ◽  
2021 ◽  
Author(s):  
Pierpaolo Trimboli ◽  
Jacopo Giannelli ◽  
Bernardo Marques ◽  
Arnoldo Piccardo ◽  
Anna Crescenzi ◽  
...  
Keyword(s):  
Thyroid Carcinoma ◽  
Medullary Thyroid Carcinoma ◽  
Meta Analysis ◽  
Needle Aspiration ◽  
Significant Heterogeneity ◽  
True Positive ◽  
False Negatives ◽  
Medullary Thyroid ◽  
Online Databases ◽  
Almost All

Abstract Purpose The sensitivity of cytology after fine needle aspiration (FNA-cytology) in detecting medullary thyroid carcinoma (MTC) is low. To overcome this problem, measuring calcitonin (CT) in washout fluid of FNA (FNA-CT) has been largely diffused and showed good performance. However, no evidence-based study exists comparing systematically the sensitivity of FNA-cytology and FNA-CT. This study aimed to systematically review the literature and collect data allowing a head-to-head comparison meta-analysis between FNA-cytology and FNA-CT in detecting MTC lesions. Methods The online databases of PubMed/MEDLINE and Scopus were searched until June 2021. Original articles reporting the use of both FNA-cytology and FNA-CT in the same series of histologically proven MTC lesions were included They were extracted general features of each study, number of MTC lesions (nodule and neck lymph nodes), and true positive and false negatives of both FNA-cytology and FNA-CT. Results Six studies were included. The sensitivity of FNA-cytology varied from 20% to 86% with a pooled value of 54% (95% CI 35–73%) and significant heterogeneity. The sensitivity of FNA-CT was higher than 95% in almost all studies with a pooled value of 98% (95% CI 96–100%) without heterogeneity. The sensitivity of FNA-CT was significantly higher than that of FNA-cytology. Conclusions FNA-CT is significantly more sensitive than FNA-cytology in detecting MTC. Accordingly, FNA-CT represents the standard method to use in patients with suspicious MTC lesions, combined with cytology.

Oncocytic variant of medullary thyroid carcinoma; a rare tumor with numerous diagnostic mimics by fine needle aspiration

2017 ◽  
Vol 45 (12) ◽  
pp. 1148-1152 ◽  
Author(s):  
Sharon B. Sams ◽  
Kenneth D. Tompkins ◽  
Sarah Mayson ◽  
Christopher D. Raeburn ◽  
Sanjana Mehrotra
Keyword(s):  
Thyroid Carcinoma ◽  
Medullary Thyroid Carcinoma ◽  
Fine Needle Aspiration ◽  
Needle Aspiration ◽  
Rare Tumor ◽  
Medullary Thyroid ◽  
Fine Needle ◽  
Oncocytic Variant

The involvement of the RET variant G691S in medullary thyroid carcinoma enlightened by a meta-analysis study

2012 ◽  
Vol 132 (12) ◽  
pp. 2808-2819 ◽  
Author(s):  
Francesca Lantieri ◽  
Francesco Caroli ◽  
Isabella Ceccherini ◽  
Paola Griseri
Keyword(s):  
Thyroid Carcinoma ◽  
Medullary Thyroid Carcinoma ◽  
Meta Analysis ◽  
Medullary Thyroid ◽  
Analysis Study

Diagnosis of pseudopapillary variant of medullary thyroid carcinoma by fine-needle aspiration cytology

2013 ◽  
Vol 42 (9) ◽  
pp. 823-826 ◽  
Author(s):  
Namiki Kawanishi ◽  
Yoshiaki Norimatsu ◽  
Hiroyuki Ohsaki ◽  
Tsutomu Yuminamochi ◽  
Ryohei Katoh ◽  
...  
Keyword(s):  
Thyroid Carcinoma ◽  
Medullary Thyroid Carcinoma ◽  
Fine Needle Aspiration ◽  
Fine Needle Aspiration Cytology ◽  
Needle Aspiration ◽  
Aspiration Cytology ◽  
Medullary Thyroid ◽  
Fine Needle ◽  
Needle Aspiration Cytology

scholarly journals Detection rate of FNA cytology in medullary thyroid carcinoma: a meta-analysis

2014 ◽  
Vol 82 (2) ◽  
pp. 280-285 ◽  
Author(s):  
Pierpaolo Trimboli ◽  
Giorgio Treglia ◽  
Leo Guidobaldi ◽  
Francesco Romanelli ◽  
Giuseppe Nigri ◽  
...  
Keyword(s):  
Thyroid Carcinoma ◽  
Medullary Thyroid Carcinoma ◽  
Detection Rate ◽  
Meta Analysis ◽  
Medullary Thyroid

scholarly journals Medullary thyroid carcinoma and pregnancy

2021 ◽  
Vol 16 (S3) ◽  
pp. 6-9
Author(s):  
Andreea Elena DUMITRU ◽  
◽  
Corina GICĂ ◽  
Anca Marina CIOBANU ◽  
Brînduşa Ana CIMPOCA-RAPTIS ◽  
...  
Keyword(s):  
Thyroid Carcinoma ◽  
Medullary Thyroid Carcinoma ◽  
Relevant Information ◽  
Needle Aspiration ◽  
Hereditary Disease ◽  
Thyroid Tumor ◽  
Medullary Thyroid ◽  
Ultrasound Evaluation ◽  
Regional Metastases

Medullary thyroid carcinoma (MTC) is a rare neuroendocrine tumor of the parafollicular cells of the thyroid gland. The tumor occurs, either sporadically or in a hereditary form, as a component of the type 2 multiple endocrine neoplasia (MEN) syndromes, MEN2A and MEN2B, both with an autosomal dominant transmission. Due to its higher aggressiveness and urgency to treat, it poses a challenge when diagnosed during pregnancy. We performed a literature review searching medical databases as UpToDate and PubMed for relevant information about diagnosis, impact, treatment, and outcome of medullary thyroid carcinoma during pregnancy. Diagnosis of MTC is established by clinical and ultrasound evaluation, followed by a fine needle aspiration biopsy. Further analyses decide whether it is a sporadic or a hereditary disease. Surgery offers the curative solution, but careful postoperative follow-up is needed for the best outcome. The decision for surgery is taken considering the DNA mutation of RET oncogene and pregnancy status. A premature planned delivery is associated with potential complications for the newborn, but it is recommended when maternal status worsens. Conclusions. Complete resection of the thyroid tumor and any local and regional metastases is the only curative solution. Timing of the intervention is extremely important to decrease fetal outcomes. Close follow-up during the postoperative period, by both biochemical and imaging methods, is needed.

scholarly journals Diagnostic Pitfall of Thyroid Fine-needle Aspiration Induced Fibrosis: Follicular Adenoma Mimicking Medullary Thyroid Carcinoma in Frozen Section

2020 ◽  
Author(s):  
Woo Sung Moon ◽  
Myoung Jae Kang ◽  
Hyun Jo Youn ◽  
Kyoung Min Kim
Keyword(s):  
Thyroid Carcinoma ◽  
Medullary Thyroid Carcinoma ◽  
Fine Needle Aspiration ◽  
Frozen Section ◽  
Follicular Adenoma ◽  
Needle Aspiration ◽  
Medullary Thyroid ◽  
Fine Needle ◽  
Histological Alterations ◽  
Diagnostic Pitfall

Abstract Background:Fine-needle aspiration (FNA) is a frequently utilized method for the diagnosis of thyroid nodules. Although the technique has clear advantages, the injury caused by the aspiration needle can induce various histological alterations. Herein, we report a case of follicular adenoma showing histological alterations possibly caused by FNA biopsy. Furthermore, the histological appearance of the lesion mimicked those of medullary thyroid carcinoma, particularly in the frozen section. Case presentation: Ultrasonography of a thyroid nodule in a 39-year-old man revealed a mass (2.2cm in diameter) in the right thyroid lobe. FNA was performed three times on the mass, and the results of the cytology were atypia of undetermined significance. Thereafter, the patient underwent right hemithyroidectomy. The histological findings of the operative frozen section analysis indicated medullary thyroid carcinoma. However, after evaluation and immunohistochemical staining of the permanent section, the mass was diagnosed as follicular adenoma with extensive fibrosis.Conclusion:The histological alterations observed in the follicular adenoma are believed to have been caused by injury during the repeated FNA procedures.

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