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2022 ◽  
Vol 23 (1) ◽  
Elena Rojano ◽  
Fernando M. Jabato ◽  
James R. Perkins ◽  
José Córdoba-Caballero ◽  
Federico García-Criado ◽  

Abstract Background Protein function prediction remains a key challenge. Domain composition affects protein function. Here we present DomFun, a Ruby gem that uses associations between protein domains and functions, calculated using multiple indices based on tripartite network analysis. These domain-function associations are combined at the protein level, to generate protein-function predictions. Results We analysed 16 tripartite networks connecting homologous superfamily and FunFam domains from CATH-Gene3D with functional annotations from the three Gene Ontology (GO) sub-ontologies, KEGG, and Reactome. We validated the results using the CAFA 3 benchmark platform for GO annotation, finding that out of the multiple association metrics and domain datasets tested, Simpson index for FunFam domain-function associations combined with Stouffer’s method leads to the best performance in almost all scenarios. We also found that using FunFams led to better performance than superfamilies, and better results were found for GO molecular function compared to GO biological process terms. DomFun performed as well as the highest-performing method in certain CAFA 3 evaluation procedures in terms of $$F_{max}$$ F max and $$S_{min}$$ S min We also implemented our own benchmark procedure, Pathway Prediction Performance (PPP), which can be used to validate function prediction for additional annotations sources, such as KEGG and Reactome. Using PPP, we found similar results to those found with CAFA 3 for GO, moreover we found good performance for the other annotation sources. As with CAFA 3, Simpson index with Stouffer’s method led to the top performance in almost all scenarios. Conclusions DomFun shows competitive performance with other methods evaluated in CAFA 3 when predicting proteins function with GO, although results vary depending on the evaluation procedure. Through our own benchmark procedure, PPP, we have shown it can also make accurate predictions for KEGG and Reactome. It performs best when using FunFams, combining Simpson index derived domain-function associations using Stouffer’s method. The tool has been implemented so that it can be easily adapted to incorporate other protein features, such as domain data from other sources, amino acid k-mers and motifs. The DomFun Ruby gem is available from Code maintained at Validation procedure scripts can be found at

2022 ◽  
Vol 12 (01) ◽  
pp. 77-98
Carme Ferré-Pavia ◽  
Mariona Codina ◽  

This article aims to analyze the strategies used by political parties on Instagram posts during the election campaign of November 10, 2019, in terms of their content and media resources, in a politainment environment. A total of 655 publications were analyzed, coming from state and autonomous Catalan parties, through content analysis with quantitative and interpretative focus. From a comparative point of view, a gap is found between new and old political parties in the use of Instagram, and it is evident that the use of per- sonalization varies between formations. In the case of Catalan parties, the campaign is mixed with the effects of the situation of their former leaders. With some exceptions, the programmatic proposals during the campaign are blurred in almost all cases. It is concluded that, on Instagram, the electoral narrative is constructed as a narrative of staged self-referential actions, with the context of the political events in the Catalan case.

2022 ◽  
Vol 19 (4) ◽  
pp. 154-157
M. A. Sudakov

Obraztsov, P. A. Igor Sikorsky: four wars and two homelands of the famous aircraft designer. Moscow, Molodaya gvardiya publishing house, 2021, 239 [1] p.: ill. (Series of biographies: The life of remarkable people; issue 1875). ISBN 978-5-235-04435-7.Igor Sikorsky created a family of the world’s best helicopters, which transported marines and doctors during almost all wars of the 20th and 21st centuries, mail and fire extinguishing equipment, oversized cargo, ordinary passengers and even US presidents. In Russia, this Russian-American genius created the world’s first huge multi-engine aircrafts Russky Vityaz [Russian Knight] and Ilya Muromets, and in America, where he was respectfully called Mister Helicopter, extraordinary seaplanes that crossed the Atlantic and Pacific Oceans even before World War II. 

Foods ◽  
2022 ◽  
Vol 11 (2) ◽  
pp. 192
Zoltan Szabo ◽  
Tamas Marosvölgyi ◽  
Eva Szabo ◽  
Viktor Koczka ◽  
Zsofia Verzar ◽  

Several polyunsaturated fatty acids are considered to have beneficial health effects, while saturated fatty acids and industrial trans fatty acids (TFAs) are linked to negative health consequences. Given the increased formation of TFAs during heating, many studies already investigated compositional changes in oils after prolonged heating or at extremely high temperatures. In contrast, our aim was to measure changes in fatty acid composition and in some health-related indices in edible oils after short-time heating that resembles the conventional household use. Potatoes were fried in palm, rapeseed, soybean, sunflower and extra virgin olive oils at 180 °C for 5 min, and samples were collected from fresh oils and after 1, 5 and 10 consecutive heating sequences. Regardless of the type of oil, the highest linoleic acid and alpha-linolenic acid values were measured in the fresh samples, whereas significantly lower values were detected in almost all samples following the heating sequences. In contrast, the lowest levels of TFAs were detected in the fresh oils, while their values significantly increased in almost all samples during heating. Indices of atherogenicity and thrombogenicity were also significantly higher in these oils after heating. The present data indicate that prolonged or repeated heating of vegetable oils should be avoided; however, the type of oil has a greater effect on the changes of health-related indices than the number of heating sequences.

Perspektif ◽  
2022 ◽  
Vol 1 (3) ◽  
pp. 284-289
Rizal Al Haque

Abstrak Sejak awal COVID-19 menyebar sampai Indonesia hampir semua bidang lumpuh. Terlebih lagi bidang media dan komunikasi. Radio Silaturahmi 720 AM Bekasi menjadi salah satu lembaga media dan komunikasi yang terkena dampak COVID-19. Radio Silaturahmi membuat strategi-strategi dan kebijakan agar bisa tetap bertahan untuk berkegiatan seperti siaran, liputan dan kegiatan lainnya. Meskipun kesulitan finansial, pihak Radio Silaturahmi (Rasil) tidak merumahkan atau memecat karyawan/kru dan juga tidak memotong gaji mereka. Rasil dalam hal ini pemilik mengalihkan status kepemilikan asetnya menjadi wakaf sepenuhnya. Hal ini dilakukan agar Rasil leluasa mengajak pendengar untuk sama-sama membiayai operasional Rasil dengan cara berdonasi. Dalam hal proses siaran, Rasil tetap menyajikan siaran-siarannya yang dikaitkan COVID-19. Akan tetapi proses siarannya tidak tatap muka langsung dan menggunakan aplikasi Zoom dengan tujuan untuk menjaga kesehatan dan keselamatan narasumber dan krunya. Abstract Since the beginning of the spread of COVID-19 to Indonesia, almost all fields have been paralyzed. Especially in the area of media and communication. Radio Silaturahim 720 AM Bekasi has become one of the media and communication institutions affected by COVID-19. Silaturahim Radio makes strategies and policies to stay afloat for broadcasting, coverage and other activities. Radio Silaturahim (Rasil) did not lay off or fire employees/crew and did not deduct their salaries despite financial difficulties. Rasil, in this case, the owner transfers the ownership status of his assets to a full wakaf so that Rasil is free to invite listeners to finance Rasil's operations by donating jointly. In terms of the broadcast process, Rasil presents his broadcasts related to COVID-19. However, the broadcast process is not face-to-face and uses the Zoom application to maintain the health and safety of the sources and crew.

Meliora ◽  
2022 ◽  
Vol 1 (2) ◽  
Hannah Rubenstein

Since its earliest performances, The Merchant of Venice garnered attention for its depiction of Shylock, the greedy Jewish moneylender who takes the protagonist of the play to court, demanding a pound of flesh. Over the centuries, depictions of this character have varied as much as the critical and popular reception to him. In the hands of each actor who newly embodies the character, Shylock can take the shape of a grotesque antisemitic caricature or a sympathetic anti-hero speaking truth to power. While Shylock began as a comic villain whose defeat allows the comedic resolution, almost all modern directors, actors, and audiences are forced to reckon with the cruel antisemitism voiced by the play’s protagonists. In tracing the performance history of this character from the turn of the 17th century, to the Third Reich, to his most recent incarnations, this research resists reducing Shylock to any single interpretation. Instead, this essay argues that Shylock serves as a reflection of the place and time in which he is performed, both an indicator of cultural attitudes and a potential instigator of cultural action towards oppression, justice, and representation of those deemed outsiders.

2022 ◽  
pp. 174387212110629
John Leubsdorf

The trials in Shakespeare’s plays are strange. There are no lawyers or professional judges, there may be no witnesses, and the adjudicator often imposes unusual sanctions such as banishment. Most strikingly, almost all the trials are fakes, manipulated by a character toward a predestined result. Two obvious explanations—that trials in Shakespeare’s day were like that, and that trials in the contemporary drama were like that—turn out to be largely incorrect. It is more persuasive to trace the strange features of Shakespeare’s trials to the various dramatic functions they fulfill, yet even this approach does not explain everything.

Materials ◽  
2022 ◽  
Vol 15 (2) ◽  
pp. 482
Kinga Korniejenko ◽  
Beata Figiela ◽  
Celina Ziejewska ◽  
Joanna Marczyk ◽  
Patrycja Bazan ◽  

The aim of this article was to analyze the fracture behavior of geopolymer composites based on fly ash or metakaolin with fine aggregate and river sand, with three types of reinforcement: glass, carbon, and aramid fiber, at three different temperatures, approximately: 3 °C, 20 °C, and 50 °C. The temperatures were selected as a future work temperature for composites designed for additive manufacturing technology. The main research method used was bending strength tests in accordance with European standard EN 12390-5. The results showed that the addition of fibers significantly improved the bending strength of all composites. The best results at room temperature were achieved for the metakaolin-based composites and sand reinforced with 2% wt. aramid fiber—17 MPa. The results at 50 °C showed a significant decrease in the bending strength for almost all compositions, which are unexpected results, taking into account the fact that geopolymers are described as materials dedicated to working at high temperatures. The test at low temperature (ca. 3 °C) showed an increase in the bending strength for almost all compositions. The grounds of this type of behavior have not been clearly stated; however, the likely causes of this are discussed.

Harold Polo

Exponential Puiseux semirings are additive submonoids of [Formula: see text] generated by almost all of the nonnegative powers of a positive rational number, and they are natural generalizations of rational cyclic semirings. In this paper, we investigate some of the factorization invariants of exponential Puiseux semirings and briefly explore the connections of these properties with semigroup-theoretical invariants. Specifically, we provide exact formulas to compute the catenary degrees of these monoids and show that minima and maxima of their sets of distances are always attained at Betti elements. Additionally, we prove that sets of lengths of atomic exponential Puiseux semirings are almost arithmetic progressions with a common bound, while unions of sets of lengths are arithmetic progressions. We conclude by providing various characterizations of the atomic exponential Puiseux semirings with finite omega functions; in particular, we completely describe them in terms of their presentations.

2022 ◽  
Rafat Y. Alwazna

The present paper addresses translation teaching during the COVID-19 outbreak, seeking to discover the challenges translation teachers encounter in online education and the solutions available to resolve them. Its importance springs from the fact that teaching almost all over the world had to depend on distant teaching/learning through electronic platforms to face the pandemic of COVID-19. Therefore, the present study seeks to discover the challenges encountered in online translation teaching and the proposed solutions to overcome them. It intends to answer the following questions: how does teaching translation during the COVID-19 outbreak look like? What are the challenges encountered in teaching translation during the COVID-19 outbreak? What are the discoveries found in teaching translation during the COVID-19 outbreak that may serve as advantages/solutions for the challenges faced? The paper uses a comprehensive questionnaire containing closed-ended and open-ended questions to elicit quantitative and qualitative data from sixty translation teachers. The data shows that 40% of the participants evaluate their online translation teaching experience during the COVID-19 outbreak as enjoyable. In contrast, no participant has assessed their online translation teaching experience as not good. About 23.33% of the participants consider their online translation teaching experience very good, and the same percentage applies to those who evaluate their online translation teaching experience as good to some extent. Thus, around 13.33% of the participants consider their online translation teaching experience good. The data also indicates that most participants have encountered obstacles in online teaching and have concurrently proposed solutions to resolve them.

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