Unexpected Widespread Bone Metastases from a BRAF K601N Mutated Follicular Thyroid Carcinoma within a Previously Resected Multinodular Goiter

2021 ◽  
Author(s):  
Andrea Repaci ◽  
Nicola Salituro ◽  
Valentina Vicennati ◽  
Fabio Monari ◽  
Ottavio Cavicchi ◽  
...  
Keyword(s):  
Thyroid Carcinoma ◽  
Bone Metastases ◽  
Multinodular Goiter ◽  
Follicular Thyroid Carcinoma

scholarly journals Xeroderma Pigmentosum: An Uncommon Risk Factor for Aggressive Follicular Thyroid Carcinoma

2021 ◽  
Vol 5 (Supplement_1) ◽  
pp. A905-A905
Author(s):  
Jillian Pattison
Keyword(s):  
Thyroid Carcinoma ◽  
Emergency Room ◽  
Xeroderma Pigmentosum ◽  
Multinodular Goiter ◽  
Follicular Thyroid Carcinoma ◽  
Thyroid Tissue ◽  
Follicular Adenoma ◽  
Relative Survival ◽  
Cervical Lymph Nodes ◽  
Increased Risk

Abstract Introduction: Follicular thyroid carcinoma (FTC) is the second most common thyroid cancer, which typically presents in an older populations, and carries a near 100% 5-year relative survival rate if diagnosed prior to cancer spreading outside of the thyroid. Clinical Case: A 26-year old female presented to emergency room with persistent jaw pain, despite course of antibiotics prescribed by dentist. She has a past medical history of xeroderma pigmentosum (XP) with over 130 surgeries for malignant skin lesions, as well as benign multinodular goiter for which she underwent total thyroidectomy at the age of 18, with pathology reporting benign tissue and follicular adenoma. Emergency room imaging of maxillofacial/sinus incompletely captured a mass in the left paratracheal region, extending into the lumen of the trachea. Patient was then transferred to University Hospital for further evaluation. Dedicated neck imaging confirmed 4.6cm mass in expected area of thyroid gland, invading into left tracheal wall, cervical esophagus, and hypopharynx. Additional imaging revealed numerous pulmonary nodules, and a 4mm enhancing focus of left superior temporal gyrus. Nuclear positron emission tomography imaging revealed regions of hypermetabolic activity in the left maxillary sinus, the facial nodules, cervical lymph nodes, and mass like region of hypermetabolic activity in the thyroid bed. Biopsy confirmed follicular thyroid parenchyma, concerning for follicular carcinoma. Patient then underwent mass resection and tracheostomy. Some thyroid tissue was left on contralateral side to malignancy due to adjacency to only functional recurrent laryngeal nerve. Pathology following surgery confirmed follicular thyroid carcinoma, with evidence of angioinvasion. Thyroglobulin mass spectrometry prior to surgery was 302 ng/mL. Conclusion: While it is well known that patients with XP suffer from early development of mucocutaneous and ocular cancers in sun-exposed areas, these patients also have increased risk for multinodular goiter as well as internal malignancies. Furthermore, treatment of any internal malignancy is limited due to inability for patients with XP to be treated with radiation. Providers for patients with XP should have very low thresholds to investigate all new symptoms aggressively, maximizing chances of diagnosing malignancies in early stages.

Bone metastasis of a follicular thyroid carcinoma originated in a toxic multinodular goiter

2008 ◽  
Vol 19 (7) ◽  
pp. e64-e66 ◽  
Author(s):  
T.S. Schmitt ◽  
J.W.F. Elte ◽  
A.P. Rietveld ◽  
H.C.T. van Zaanen ◽  
M. Castro Cabezas
Keyword(s):  
Bone Metastasis ◽  
Thyroid Carcinoma ◽  
Multinodular Goiter ◽  
Follicular Thyroid Carcinoma ◽  
Toxic Multinodular Goiter

Minimally Invasive Follicular Thyroid Carcinoma Developed in Dyshormonogenetic Multinodular Goiter Due to Thyroid Peroxidase Gene Mutation

Thyroid ◽  
2012 ◽  
Vol 22 (5) ◽  
pp. 542-546 ◽  
Author(s):  
Elena Chertok Shacham ◽  
Avraham Ishay ◽  
Elmalah Irit ◽  
Joachim Pohlenz ◽  
Yardena Tenenbaum-Rakover
Keyword(s):  
Thyroid Carcinoma ◽  
Minimally Invasive ◽  
Gene Mutation ◽  
Multinodular Goiter ◽  
Follicular Thyroid Carcinoma ◽  
Thyroid Peroxidase ◽  
Peroxidase Gene

Minimal Invasive Follicular Thyroid Carcinoma Developed in Dyshormonogenetic Multinodular Goiter Due to Thyroid Peroxidase Gene Mutation

Thyroid ◽  
2012 ◽  
pp. 120119214116000 ◽  
Author(s):  
Yardena Tenenbaum Rakover ◽  
elena chertok shacham ◽  
Avraham Ishay ◽  
Irit Elmalah ◽  
Pohlenz Joachim
Keyword(s):  
Thyroid Carcinoma ◽  
Gene Mutation ◽  
Multinodular Goiter ◽  
Follicular Thyroid Carcinoma ◽  
Minimal Invasive ◽  
Thyroid Peroxidase ◽  
Peroxidase Gene

131J-speichernde pulmonale und ossäre Metastasen differenzierter Schilddrüsenkarzinome bei niedrigem Serum-Thyreoglobulinspiegel – Ausnahme in der Tumornachsorge?

1987 ◽  
Vol 26 (03) ◽  
pp. 139-142 ◽  
Author(s):  
G. Arning ◽  
O. Schober ◽  
H. Hundeshagen ◽  
Ch. Ehrenheim
Keyword(s):  
Serum Level ◽  
Thyroid Carcinoma ◽  
Bone Metastases ◽  
Differentiated Thyroid Carcinoma ◽  
Serum Thyroglobulin ◽  
Thyroglobulin Level ◽  
Low Serum

In the follow-up of differentiated thyroid carcinoma it is discussed whether the tumormarker thyroglobulin can replace the1311 scan, especially when the thyroglobulin serum level is normal. A positive1311 scan of metastases in the follow-up of patients with differentiated thyroid carcinoma combined with a low serum thyroglobulin level is extremely rare. The literature shows a frequency of about 4%. Recently we found 3 cases with a positive1311 scan demonstrating pulmonary and bone metastases whereas the serum thyroglobulin level was low.

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