Aromatase inhibitor anastrozole as a second-line hormonal treatment to a recurrent low-grade endometrial stromal sarcoma: a case report

2010 ◽  
Vol 28 (3) ◽  
pp. 771-774 ◽  
Author(s):  
Keiko Shoji ◽  
Katsutoshi Oda ◽  
Shunsuke Nakagawa ◽  
Kei Kawana ◽  
Toshiharu Yasugi ◽  
...  
Keyword(s):  
Case Report ◽  
Aromatase Inhibitor ◽  
Hormonal Treatment ◽  
Endometrial Stromal Sarcoma ◽  
Low Grade ◽  
Second Line ◽  
Stromal Sarcoma

scholarly journals Letrozole as second-line hormonal treatment for recurrent low-grade endometrial stromal sarcoma: A case report and review of the literature

2016 ◽  
Vol 12 (5) ◽  
pp. 3856-3860 ◽  
Author(s):  
Kohei Nakamura ◽  
Kentaro Nakayama ◽  
Masako Ishikawa ◽  
Noriyoshi Ishikawa ◽  
Hiroshi Katagiri ◽  
...  
Keyword(s):  
Case Report ◽  
Hormonal Treatment ◽  
Endometrial Stromal Sarcoma ◽  
Low Grade ◽  
Second Line ◽  
Review Of The Literature ◽  
Stromal Sarcoma

scholarly journals CT, MRI, and FDG-PET imaging findings of low-grade extrauterine endometrial stromal sarcoma arising from the mesentery: A case report

2021 ◽  
Vol 16 (9) ◽  
pp. 2774-2779
Author(s):  
Satoshi Suzuki ◽  
Ryo Kurokawa ◽  
Tetsushi Tsuruga ◽  
Mayuyo Mori‑Uchino ◽  
Haruka Nishida ◽  
...  
Keyword(s):  
Case Report ◽  
Pet Imaging ◽  
Fdg Pet ◽  
Endometrial Stromal Sarcoma ◽  
Low Grade ◽  
Imaging Findings ◽  
Stromal Sarcoma

scholarly journals Low-Grade Endometrial Stromal Sarcoma in a 22-Year-Old Maiden Female: A Rare Case Report from Syria

2021 ◽  
Vol 2021 ◽  
pp. 1-4
Author(s):  
Lana Nseir ◽  
Georget Mansour ◽  
Junior Makhoul ◽  
Luna Skaf ◽  
Mohammad Ziad Dahhan ◽  
...  
Keyword(s):  
Case Report ◽  
Rare Case ◽  
Treatment Plan ◽  
Endometrial Stromal Sarcoma ◽  
Abnormal Uterine Bleeding ◽  
Low Grade ◽  
Stromal Sarcoma ◽  
Rapid Enlargement ◽  
Rare Case Report ◽  
Immunohistochemical Studies

Endometrial stromal sarcoma (ESS) is a rare and challenging type of endometrial tumor, constituting only about 0.2% of all uterine malignancies and occurring in women 42–58 years of age. ESS is usually misdiagnosed as leiomyoma. They both have nonspecific symptoms, which makes the diagnosis of ESS difficult to achieve. As the ESS is infrequently encountered, optimal management is quite debatable. Here, we report a rare case of a 22-year-old Syrian female who presented with abnormal uterine bleeding; the preoperative diagnosis suggested leiomyoma while histopathological and immunohistochemical studies confirmed the diagnosis of LG-ESS stage IIA. Therefore, the treatment plan was shifted from a conservative myomectomy to a total hysterectomy with both adnexa. The aim of this case report is to draw attention to this uncommon tumor at young age of patients as well as to have awareness of the necessity to suspect this diagnosis especially with the presentation of rapid enlargement of uterine leiomyoma.

Metastatic low‐grade endometrial stromal sarcoma after 24 years: A case report and review of recent molecular genetics

2020 ◽  
Author(s):  
Andres E. Mindiola‐Romero ◽  
Xiaoying Liu ◽  
Jessica L. Dillon ◽  
Michael Talarico ◽  
Geoffrey Smith ◽  
...  
Keyword(s):  
Case Report ◽  
Molecular Genetics ◽  
Endometrial Stromal Sarcoma ◽  
Low Grade ◽  
Stromal Sarcoma

A Rare Case Report of Primary Low-Grade Endometrial Stromal Sarcoma (LGESS) of Ovary Infiltrating Bladder

2016 ◽  
Vol 14 (3) ◽  
Author(s):  
Senthil Kumar Ravichander ◽  
Ajay Krishna Boralkar ◽  
Neha Deepak Borde ◽  
Amol Rangnath Jadhav ◽  
Jyothi Sachin Mukhedkar
Keyword(s):  
Case Report ◽  
Rare Case ◽  
Endometrial Stromal Sarcoma ◽  
Low Grade ◽  
Stromal Sarcoma ◽  
Rare Case Report

scholarly journals Laparoscopic Resection for Recurrent Pelvic Disseminations of a Low Grade Endometrial Stromal Sarcoma: Case Report

2014 ◽  
Vol 30 (1) ◽  
pp. 193-198
Author(s):  
Takafumi Oshita ◽  
Katsuyuki Tomono ◽  
Takako Katsube ◽  
Kei Okamoto ◽  
Takefumi Akagi ◽  
...  
Keyword(s):  
Case Report ◽  
Laparoscopic Resection ◽  
Endometrial Stromal Sarcoma ◽  
Low Grade ◽  
Stromal Sarcoma

scholarly journals Pleural Metastasis of High-Grade Endometrial Stromal Sarcoma With YWHAE Gene (17p13.3) Rearrangement, A Rare Case Report

2021 ◽  
Vol 156 (Supplement_1) ◽  
pp. S41-S41
Author(s):  
A C Re ◽  
M Enrique ◽  
S Ren
Keyword(s):  
Case Report ◽  
Spindle Cell ◽  
Malignant Neoplasm ◽  
Endometrial Stromal Sarcoma ◽  
Low Grade ◽  
High Grade ◽  
Stromal Sarcoma ◽  
Uterine Tumors ◽  
Uterine Neoplasm ◽  
Left Pleural Effusion

Abstract Introduction/Objective Endometrial stromal sarcoma (ESS), a rare malignant neoplasm of endometrial stroma, accounts for less than 1% of all uterine tumors. High grade ESS (HGESS) is aggressive and commonly relapses even after surgical and neoadjuvant therapy. Abdominal and pelvic regions are common sites of metastasis, however, distant metastases to the liver, lung, vertebrae, and brain have been reported. Methods/Case Report We encountered a 49-year-old female who presented with shortness of breath, found to have a left pleural effusion and multiple pleural masses. She initially presented three years ago with heavy irregular menses and left pelvic pain for one year. D&C revealed prominent small spindle cells for which a stromal nodule and low-grade or malignant process was probable. CT scan showed an enlarged uterus. Hysterectomy with bilateral salpingo- oophorectomy, bilateral pelvic and para-aortic lymph node dissection, and partial omentectomy were performed. The uterus revealed an intramural 7 cm mass with a serpiginous growth pattern and lymphovascular invasion. Tumor cells were plump to spindled with areas of high cellularity, rounded nuclei, increased atypia and mitosis. Atypical areas were positive for cyclin D1, focally positive for CD10, and negative for ER, PR, SMA, desmin, AE1/3 and CAM5.2. FISH studies showed rearrangement of YWHAE gene (17p13.3) and no rearrangement of JAZF1 or PHF1 gene regions. Findings supported the diagnosis of HGESS. The patient received post-operative chemotherapy. Biopsy of the current pleural lesion revealed a nonspecific malignant spindle cell neoplasm positive for BCL1, CD56, CD117, CD99, TLE1 and INI1, while negative for AE1/3, CAM5.2, EMA, ER, PR, CK5/6, calretinin, SMA, desmin and S100. The CD10 stain was inconclusive. FISH studies showed rearrangement of YWHAE gene (17p13.3) and no rearrangement involving JAZF1 or PHF1 gene regions. No rearrangement of the SS18 gene region was observed and synovial sarcoma was excluded. Overall findings support the diagnosis of metastatic HGESS. Results (if a Case Study enter NA) NA Conclusion HGESS, a rare tumor with a nonspecific immunostain profile, has the ability to metastasize to rare body sites, such as the pleura in our case. Display of spindle cell morphology is a nonspecific finding that raises broad differential diagnoses. In women, with or without a history of uterine neoplasm, HGESS is a clinically worthwhile diagnosis to be mindful of.

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