scholarly journals FDG-PET/CT and diffusion-weighted imaging for resected lung cancer: correlation of maximum standardized uptake value and apparent diffusion coefficient value with prognostic factors

2018 ◽  
Vol 35 (5) ◽  
Author(s):  
Katsuo Usuda ◽  
Aika Funasaki ◽  
Atsushi Sekimura ◽  
Nozomu Motono ◽  
Munetaka Matoba ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Diffusion Coefficient ◽  
Diffusion Weighted Imaging ◽  
Standardized Uptake Value ◽  
Maximum Standardized Uptake Value ◽  
Apparent Diffusion Coefficient Value ◽  
Pet Ct ◽  
Apparent Diffusion ◽  
Fdg Pet Ct ◽  
And Diffusion

The Clinical Impact of the Sum of the Maximum Standardized Uptake Value on the Pretreatment with18F-FDG-PET/CT in Small-Cell Lung Cancer

Oncology ◽  
2014 ◽  
Vol 86 (1) ◽  
pp. 1-9 ◽  
Author(s):  
Se-Il Go ◽  
Haa-Na Song ◽  
Jung-Hun Kang ◽  
Myung Hee Kang ◽  
Moon Jin Kim ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Fdg Pet ◽  
Standardized Uptake Value ◽  
Small Cell ◽  
Clinical Impact ◽  
Small Cell Lung ◽  
Maximum Standardized Uptake Value ◽  
Pet Ct ◽  
Fdg Pet Ct

Ratio between maximum standardized uptake value of N1 lymph nodes and tumor predicts N2 disease in patients with non-small cell lung cancer in 18F-FDG PET-CT scan

2016 ◽  
Vol 35 (3) ◽  
pp. 159-164 ◽  
Author(s):  
A.F. Honguero Martínez ◽  
M.D. García Jiménez ◽  
A. García Vicente ◽  
J. López-Torres Hidalgo ◽  
M.J. Colon ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Standardized Uptake Value ◽  
Small Cell ◽  
Small Cell Lung ◽  
Maximum Standardized Uptake Value ◽  
N2 Disease ◽  
Pet Ct ◽  
18F Fdg ◽  
Fdg Pet Ct ◽  
Pet Ct Scan

scholarly journals Relationship between tumor mutational burden and maximum standardized uptake value in 2-[18F]FDG PET (positron emission tomography) scan in cancer patients

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Amin Haghighat Jahromi ◽  
Donald A. Barkauskas ◽  
Matthew Zabel ◽  
Aaron M. Goodman ◽  
Garret Frampton ◽  
...  
Keyword(s):  
Fdg Pet ◽  
Standardized Uptake Value ◽  
Emission Tomography ◽  
Maximum Standardized Uptake Value ◽  
Tissue Biopsy ◽  
Mutational Burden ◽  
Positron Emission ◽  
Pet Ct ◽  
Tumor Mutational Burden ◽  
Fdg Pet Ct

Abstract Purpose Deriving links between imaging and genomic markers is an evolving field. 2-[18F]FDG PET/CT (18F-fluorodeoxyglucose positron emission tomography–computed tomography) is commonly used for cancer imaging, with maximum standardized uptake value (SUVmax) as the main quantitative parameter. Tumor mutational burden (TMB), the quantitative variable obtained using next-generation sequencing on a tissue biopsy sample, is a putative immunotherapy response predictor. We report the relationship between TMB and SUVmax, linking these two important parameters. Methods In this pilot study, we analyzed 1923 patients with diverse cancers and available TMB values. Overall, 273 patients met our eligibility criteria in that they had no systemic treatment prior to imaging/biopsy, and also had 2-[18F]FDG PET/CT within 6 months prior to the tissue biopsy, to ensure acceptable temporal correlation between imaging and genomic evaluation. Results We found a linear correlation between TMB and SUVmax (p < 0.001). In the multivariate analysis, only TMB independently correlated with SUVmax, whereas age, gender, and tumor organ did not. Conclusion Our observations link SUVmax in readily available, routinely used, and noninvasive 2-[18F]FDG PET/CT imaging to the TMB, which requires a tissue biopsy and time to process. Since higher TMB has been implicated as a prognostic biomarker for better outcomes after immunotherapy, further investigation will be needed to determine if SUVmax can stratify patient response to immunotherapy.

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