Possible protective effect of pantoprazole against cisplatin-induced nephrotoxicity in head and neck cancer patients: a randomized controlled trial

2021 ◽  
Vol 38 (9) ◽  
Author(s):  
Eman Ghonaim ◽  
Sahar El-Haggar ◽  
Suzy Gohar
Keyword(s):  
Randomized Controlled Trial ◽  
Head And Neck Cancer ◽  
Protective Effect ◽  
Head And Neck ◽  
Cancer Patients ◽  
Neck Cancer ◽  
Controlled Trial ◽  
Randomized Controlled

scholarly journals Alleviation of dry mouth by saliva substitutes improved swallowing ability and clinical nutritional status of post-radiotherapy head and neck cancer patients: a randomized controlled trial

2019 ◽  
Vol 28 (6) ◽  
pp. 2817-2828 ◽  
Author(s):  
Sumalee Nuchit ◽  
Aroonwan Lam-ubol ◽  
Wannaporn Paemuang ◽  
Sineepat Talungchit ◽  
Orapin Chokchaitam ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Head And Neck Cancer ◽  
Nutritional Status ◽  
Head And Neck ◽  
Cancer Patients ◽  
Neck Cancer ◽  
Controlled Trial ◽  
Dry Mouth ◽  
Randomized Controlled ◽  
Saliva Substitutes

Abstract Purpose The aim of this study is to investigate the effect of an edible saliva substitute, oral moisturizing jelly (OMJ), and a topical saliva gel (GC) on dry mouth, swallowing ability, and nutritional status in post-radiotherapy head and neck cancer patients. Methods Sixty-two post-radiation head and neck cancer patients with xerostomia completed a blinded randomized controlled trial. They were advised to swallow OMJ (n = 31) or apply GC orally (n = 31) for 2 months. Outcome measures were assessed at baseline, 1, and 2 months, including subjective and objective dry mouth (Challcombe) scores, subjective swallowing problem scores (EAT-10), water swallowing time, clinical nutritional status (PG-SGA), body weight, and dietary intake. Results After 1 and 2 months of interventions, subjective and objective dry mouth scores, subjective swallowing problem scores, swallowing times, and clinical nutritional status in both groups were significantly improved (p < 0.0001). Compared to GC, OMJ group had higher percent improvement in all outcome measures (p < 0.001) except swallowing time and clinical nutritional status. Interestingly, subjective dry mouth scores were significantly correlated with subjective swallowing problem scores (r = 0.5321, p < 0.0001). Conclusions Continuous uses of saliva substitutes (OMJ or GC) for at least a month improved signs and symptoms of dry mouth and enhanced swallowing ability. An edible saliva substitute was superior to a topical saliva gel for alleviating dry mouth and swallow problems. These lead to improved clinical nutritional status. Thus, palliation of dry mouth may be critical to support nutrition of post-radiotherapy head and neck cancer patients. Clinical trial registry Clinicaltrials.gov NCT03035825

scholarly journals Exercise and nutrition for head and neck cancer patients: a patient oriented, clinic-supported randomized controlled trial

BMC Cancer ◽  
2012 ◽  
Vol 12 (1) ◽  
Author(s):  
Lauren C Capozzi ◽  
Harold Lau ◽  
Raylene A Reimer ◽  
Margaret McNeely ◽  
Janine Giese-Davis ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Head And Neck Cancer ◽  
Head And Neck ◽  
Cancer Patients ◽  
Neck Cancer ◽  
Controlled Trial ◽  
Randomized Controlled

The effect of the use of thyme honey in minimizing radiation - induced oral mucositis in head and neck cancer patients: A randomized controlled trial

2018 ◽  
Vol 34 ◽  
pp. 89-97 ◽  
Author(s):  
Melanie Charalambous ◽  
Vasilios Raftopoulos ◽  
Lefkios Paikousis ◽  
Nicos Katodritis ◽  
Ekaterini Lambrinou ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Head And Neck Cancer ◽  
Head And Neck ◽  
Cancer Patients ◽  
Neck Cancer ◽  
Oral Mucositis ◽  
Controlled Trial ◽  
Randomized Controlled ◽  
Radiation Induced ◽  
Thyme Honey

scholarly journals OC-0631 Stem cell sparing IMRT for head and neck cancer patients: a double-blind randomized controlled trial

2019 ◽  
Vol 133 ◽  
pp. S335-S336
Author(s):  
R. Steenbakkers ◽  
M. Stokman ◽  
R. Kierkels ◽  
M. Schuurman ◽  
A. Van den Hoek ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Head And Neck Cancer ◽  
Stem Cell ◽  
Head And Neck ◽  
Cancer Patients ◽  
Neck Cancer ◽  
Controlled Trial ◽  
Double Blind ◽  
Randomized Controlled
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