Increased FDG uptake in breast cancer is associated with prognostic factors

2012 ◽  
Vol 26 (4) ◽  
pp. 345-350 ◽  
Author(s):  
Yasemin Sanli ◽  
Serkan Kuyumcu ◽  
Zeynep Gozde Ozkan ◽  
Göknur Işık ◽  
Hasan Karanlik ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Prognostic Factors ◽  
Fdg Uptake

Correlation of high 18F-FDG uptake to clinical, pathological and biological prognostic factors in breast cancer

2010 ◽  
Vol 38 (3) ◽  
pp. 426-435 ◽  
Author(s):  
David Groheux ◽  
Sylvie Giacchetti ◽  
Jean-Luc Moretti ◽  
Raphael Porcher ◽  
Marc Espié ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Prognostic Factors ◽  
Fdg Uptake ◽  
18F Fdg ◽  
Biological Prognostic Factors

Relationship Between 18F-FDG Uptake with Clinicopathological Prognostic Factors and Biological Subtypes in Breast Cancer

2021 ◽  
Author(s):  
Aykut Soyder ◽  
İbrahim Halil Erdoğdu ◽  
Arzu Cengiz ◽  
Eyüp Murat Yılmaz ◽  
Murat Demir ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Prognostic Factors ◽  
Fdg Uptake ◽  
18F Fdg

Correlation between 18F-FDG uptake on PET/CT and prognostic factors in triple-negative breast cancer

2015 ◽  
Vol 25 (11) ◽  
pp. 3314-3321 ◽  
Author(s):  
Hye Ryoung Koo ◽  
Jeong Seon Park ◽  
Keon Wook Kang ◽  
Wonshik Han ◽  
In Ae Park ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Prognostic Factors ◽  
Triple Negative Breast Cancer ◽  
Triple Negative ◽  
Fdg Uptake ◽  
Pet Ct ◽  
18F Fdg

Correlation of the maximum standardized uptake value for f-18 fluorodeoxyglucose with molecular subtype and survival in advanced breast cancer.

2012 ◽  
Vol 30 (15_suppl) ◽  
pp. 10567-10567
Author(s):  
Zhen Jia ◽  
Xi-Chun Hu ◽  
Yingjian Zhang ◽  
Min Zhou ◽  
Biyun Wang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Prognostic Factors ◽  
Glucose Metabolism ◽  
Advanced Breast Cancer ◽  
Treatment Efficacy ◽  
Molecular Subtypes ◽  
Standardized Uptake Value ◽  
Advanced Breast ◽  
Fdg Uptake ◽  
Maximum Standardized Uptake Value

10567 Background: Tumor glucose metabolism correlates with tumor biology and clinical outcome of breast cancer patients. This prospective cohort study was to explore correlations of 18F-FDG uptake, a surrogate for glucose metabolism, with molecular subtypes in women with advanced breast cancer. Methods: Patients diagnosed as advanced breast cancer were enrolled in the study. PET/CT was performed and the Maximum Standardized Uptake Value (SUVmax) of each lesion was documented as baseline, so was clinical and treatment information. Diagnosis of malignant nature of a lesion was confirmed by pathology or further follow-up. Patients who had got a progressive disease in the efficacy assessment were assigned new treatments as per-institutional guidelines. Results: 244 patients met the criteria and were all put into this analysis. Independent factors for influencing SUVmax value included luminal subtype (p= 0.002), triple-negative subtype (p<0.001), ER status (p= 0.028), Her-2 status (p<0.001), and CEA level (p<0.001). A higher SUVmax was significantly associated with poorer median PFS (6.9 vs. 8.1 months, p=0.040) and OS (13.8 vs. 16.9 months, p=0.003). Cox Regression analysis showed that SUVmax value, previous treatments, subsequent treatments and treatment efficacy were four independent prognostic factors for PFS, while age, menopausal status, disease free interval, 4 subtypes, previous treatments, number of metastatic sites, SUVmax value and subsequent treatment efficacy were independent prognostic factors for OS. Conclusions: 18F-FDG uptake correlates with molecular subtypes in women with advanced breast cancer. Baseline SUVmax is an independent prognostic factor for survival of patients with advanced breast cancer, especially those with luminal subtypes.

scholarly journals Dual-Time-Point FDG Uptake Correlates with Prognostic Factors of Invasive Breast Cancer: Clinical Usefulness of Early Delayed Scanning

Diagnostics ◽  
2019 ◽  
Vol 9 (2) ◽  
pp. 40
Author(s):  
Ji Young Lee ◽  
Hee-Sung Song ◽  
Jae Hyuck Choi ◽  
Chang Lim Hyun
Keyword(s):  
Breast Cancer ◽  
Prognostic Factors ◽  
Invasive Breast Cancer ◽  
Histologic Grade ◽  
Prognostic Parameters ◽  
Ki 67 ◽  
Fdg Uptake ◽  
Pet Ct ◽  
Dual Time Point ◽  
Time Point

This study investigated correlations between fluorodeoxyglucose (FDG) uptake in tumors as assessed by modified dual-time-point (mDTP) FDG positron emission tomography/computed tomography (PET/CT) in invasive breast cancer (iBC) and several prognostic parameters. Thirty-two women who underwent mastectomies for iBC were retrospectively evaluated. mDTP scanning was performed using standard FDG PET/CT (PET1), followed by early delayed acquisition (PET2) without repositioning and additional CT scanning. Using maximal standardized uptake values on PET1 (SUV1) and PET2 (SUV2) in the primary breast tumor, the percentage changes between SUV1 and SUV2 (retention index, (RI)) were calculated. Prognostic parameters (e.g., tumor size and stage; number of metastatic lymph nodes; histologic grade; expression of estrogen receptor (ER), progesterone, epidermal growth factor receptor (HER-2), and p53; and the Ki-67 labeling index (LI)) were evaluated from the surgical specimens. PET2 scans were conducted 17.7 ± 1.5 min after PET1. RI values gradually increased as the histologic grade increased (p = 0.016), and were significantly higher when ER expression was absent (p = 0.023) and Ki-67 LI was high (p < 0.001). RI values also showed a moderately positive correlation with Ki-67 LI (r = 0.629; p < 0.001). RI correlated with well-known biologic prognostic factors of iBC and mDTP scanning, which could be used as a substitute for conventional DTP PET.

Prognostic Factors in Breast Cancer

1989 ◽  
Vol 3 (4) ◽  
pp. 641-652 ◽  
Author(s):  
Douglas E. Merkel ◽  
C. Kent Osborne
Keyword(s):  
Breast Cancer ◽  
Prognostic Factors
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