Perceived physical fatigability improves after an exercise intervention among breast cancer survivors: a randomized clinical trial

Breast Cancer ◽  
2021 ◽  
Vol 29 (1) ◽  
pp. 30-37
Author(s):  
Yujia Qiao ◽  
G. J. van Londen ◽  
Jill W. Brufsky ◽  
Janette T. Poppenberg ◽  
Rebecca W. Cohen ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Clinical Trial ◽  
Cancer Survivors ◽  
Randomized Clinical Trial ◽  
Breast Cancer Survivors ◽  
Exercise Intervention

Perceived physical fatigability improves after an exercise intervention among breast cancer survivors: A pilot randomized clinical trial.

2021 ◽  
Vol 39 (15_suppl) ◽  
pp. 12050-12050
Author(s):  
Yujia (Susanna) Qiao ◽  
G J. Van Londen ◽  
Jill Brufsky ◽  
Janette T. Poppenberg ◽  
Rebecca W. Cohen ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Clinical Trial ◽  
Cancer Survivors ◽  
Randomized Clinical Trial ◽  
Breast Cancer Survivors ◽  
Exercise Intervention ◽  
Exercise Group ◽  
Whole Body ◽  
Control Group ◽  
Patient Reported

12050 Background: Among breast cancer populations, exercise interventions resulted in positive but relatively small improvements on fatigue, which may have been masked by using single-item, non-specific measures of global fatigue. Perceived fatigability – whole-body tiredness anchored to standardized tasks/activities of specific intensity and duration – accounts for self-pacing bias as an individual likely titrates their usual activities and exertion level to avoid exhaustion. We examined whether this novel fatigability measure could replace global fatigue in an exercise intervention trial in breast cancer survivors. Methods: This pilot single-center randomized clinical trial of 49 breast cancer survivors was conducted from 2015-17, among which 41 participants (exercise = 22, control = 19) completed the trial and reported their perceived physical fatigability and global fatigue at the first (V1) and the last visit (V3). Perceived physical fatigability was measured using the 10-item, self-administered Pittsburgh Fatigability Scale (PFS) scored 0-50, higher PFS Physical scores = greater fatigability. Global fatigue was assessed with a single question “I have a lack of energy” scored 0 “not at all” to 4 “very much” from the Functional Assessment of Cancer Therapy-Endocrine Subscale (FACT-ES). The exercise intervention consisted of three one-on-one training sessions over 6-14 weeks, plus two optional email/phone consultations. The trainer developed a personalized, home-based exercise program with a goal of achieving the recommended ≥150 minutes/week of moderate to vigorous exercise based on ACSM guidelines. Those randomized to the control group met the trainer for V1 and again 6-14 weeks later at V3, but no exercise prescription was provided. We computed mean differences in perceived physical fatigability and global fatigue between V3 and V1 and compared by intervention groups. Results: Among the 41 women in the study (mean age = 54.9±9.8 years; 80% white), sociodemographic and clinical characteristics were similar by intervention groups, except for antiestrogen use. Post-intervention changes (mean ± SE) in PFS Physical scores were -4.4±1.4 (-22.5%) in the exercise group and 0.2±1.4 (+1.0%) in the control group (p =.022), whereas change in global fatigue scores were -0.64±0.23 in the exercise group and 0.00±0.22 in the control group (p =.054). Conclusions: These findings add to mounting evidence that an exercise intervention reduces fatigue among breast cancer survivors. Importantly, the PFS showed a clinically meaningful reduction after the exercise intervention that was masked when using global fatigue as the measurement. Therefore, the PFS serves as a more sensitive instrument to measure perceived physical fatigability and can better evaluate patient-reported outcomes in future cancer trials, especially those focused on cancer survivorship. Clinical trial information: NCT 02770781.

scholarly journals Telehealth system (e-CUIDATE) to improve quality of life in breast cancer survivors: rationale and study protocol for a randomized clinical trial

Trials ◽  
2013 ◽  
Vol 14 (1) ◽  
pp. 187 ◽  
Author(s):  
Noelia Galiano-Castillo ◽  
Angelica Ariza-García ◽  
Irene Cantarero-Villanueva ◽  
Carolina Fernández-Lao ◽  
Lourdes Díaz-Rodríguez ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Quality Of Life ◽  
Clinical Trial ◽  
Cancer Survivors ◽  
Randomized Clinical Trial ◽  
Study Protocol ◽  
Breast Cancer Survivors ◽  
Improve Quality

Cognitive rehabilitation group intervention for breast cancer survivors: results of a randomized clinical trial

2015 ◽  
Vol 24 (11) ◽  
pp. 1360-1367 ◽  
Author(s):  
L. M. Ercoli ◽  
L. Petersen ◽  
A. M. Hunter ◽  
S. A. Castellon ◽  
L. Kwan ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Clinical Trial ◽  
Cancer Survivors ◽  
Randomized Clinical Trial ◽  
Group Intervention ◽  
Cognitive Rehabilitation ◽  
Breast Cancer Survivors

Qigong/Tai Chi Easy for fatigue in breast cancer survivors: Rationale and design of a randomized clinical trial

2016 ◽  
Vol 50 ◽  
pp. 222-228 ◽  
Author(s):  
Linda Larkey ◽  
Jennifer Huberty ◽  
Maja Pedersen ◽  
Karen Weihs
Keyword(s):  
Breast Cancer ◽  
Clinical Trial ◽  
Cancer Survivors ◽  
Randomized Clinical Trial ◽  
Breast Cancer Survivors ◽  
Tai Chi

scholarly journals Fatigue reduction diet in breast cancer survivors: a pilot randomized clinical trial

2016 ◽  
Vol 161 (2) ◽  
pp. 299-310 ◽  
Author(s):  
Suzanna Maria Zick ◽  
Justin Colacino ◽  
Maria Cornellier ◽  
Tohfa Khabir ◽  
Katie Surnow ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Clinical Trial ◽  
Cancer Survivors ◽  
Randomized Clinical Trial ◽  
Breast Cancer Survivors

scholarly journals Integral strategy to supportive care in breast cancer survivors through occupational therapy and a m-health system: design of a randomized clinical trial

2016 ◽  
Vol 16 (1) ◽  
Author(s):  
Mario Lozano-Lozano ◽  
Lydia Martín-Martín ◽  
Noelia Galiano-Castillo ◽  
Francisco Álvarez-Salvago ◽  
Irene Cantarero-Villanueva ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Clinical Trial ◽  
Occupational Therapy ◽  
Supportive Care ◽  
Cancer Survivors ◽  
Health System ◽  
System Design ◽  
Randomized Clinical Trial ◽  
Breast Cancer Survivors
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