Panitumumab: A Review of Clinical Pharmacokinetic and Pharmacology Properties After Over a Decade of Experience in Patients with Solid Tumors

Advances in Therapy ◽

10.1007/s12325-021-01809-4 ◽

2021 ◽

Author(s):

Johannes Kast ◽

Sandeep Dutta ◽

Vijay V. Upreti

Keyword(s):

Solid Tumors ◽

Clinical Pharmacokinetic

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Abstract C32: First‐in‐human clinical, pharmacokinetic (PK) and pharmacodynamic (PD) phase I study of the first‐in‐class spliceosome inhibitor E7107 administered IV (bolus) on days 1, 8, and 15 every 28 days to patients with solid tumors

10.1158/1535-7163.targ-09-c32 ◽

2009 ◽

Author(s):

Ferry A. Eskens ◽

Francisco J. Ramos ◽

Herman Burger ◽

Maja JA de Jonge ◽

Jantien Wanders ◽

...

Keyword(s):

Phase I ◽

Solid Tumors ◽

Clinical Pharmacokinetic ◽

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Phase I clinical, pharmacokinetic, and pharmacodynamic study of KOS-862 (Epothilone D) in patients with advanced solid tumors and lymphoma

Investigational New Drugs ◽

10.1007/s10637-011-9765-7 ◽

2011 ◽

Vol 30 (6) ◽

pp. 2294-2302 ◽

Author(s):

Jason Konner ◽

Rachel N. Grisham ◽

Jae Park ◽

Owen A. O’Connor ◽

Gillian Cropp ◽

...

Keyword(s):

Phase I ◽

Solid Tumors ◽

Clinical Pharmacokinetic ◽

Advanced Solid Tumors ◽

Epothilone D ◽

Pharmacodynamic Study

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Final report of phase I clinical, pharmacokinetic (PK), pharmacodynamic (PD) study of PF-00562271 targeting focal adhesion kinase (FAK) in patients (pts) with solid tumors.

Journal of Clinical Oncology ◽

10.1200/jco.2010.28.15_suppl.3028 ◽

2010 ◽

Vol 28 (15_suppl) ◽

pp. 3028-3028 ◽

Author(s):

N. C. Dhani ◽

H. A. Burris ◽

L. L. Siu ◽

D. R. Camidge ◽

L. R. Mileshkin ◽

...

Keyword(s):

Phase I ◽

Focal Adhesion Kinase ◽

Solid Tumors ◽

Clinical Pharmacokinetic ◽

Focal Adhesion ◽

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Abstract A185: Phase I clinical, pharmacokinetic, and pharmacodynamic study of SB939, an oral histone deacetylase inhibitor (HDACi), in patients with advanced solid tumors

10.1158/1535-7163.targ-09-a185 ◽

2009 ◽

Author(s):

Lillian L. Siu ◽

Sebastien J. Hotte ◽

Eric X. Chen ◽

Hal W. Hirte ◽

Jean Powers ◽

...

Keyword(s):

Phase I ◽

Solid Tumors ◽

Histone Deacetylase ◽

Clinical Pharmacokinetic ◽

Histone Deacetylase Inhibitor ◽

Advanced Solid Tumors ◽

Deacetylase Inhibitor ◽

Pharmacodynamic Study

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374 Clinical, pharmacokinetic (PK) and pharmacodynamic (PD) results of first-in-man phase I trial of the orally available MEK-inhibitor MSC1936369 (AS703026) in patients (pts) with advanced solid tumors

European Journal of Cancer Supplements ◽

10.1016/s1359-6349(10)72081-4 ◽

2010 ◽

Vol 8 (7) ◽

pp. 118 ◽

Author(s):

A. Awada ◽

N. Houedé ◽

J.P. Delord ◽

M. Dubuisson ◽

A. Italiano ◽

...

Keyword(s):

Phase I ◽

Solid Tumors ◽

Clinical Pharmacokinetic ◽

Phase I Trial ◽

Mek Inhibitor ◽

Advanced Solid Tumors

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Clinical, pharmacokinetic (PK), pharmacodynamic findings in a phase I trial of weekly (wkly) intravenous AZD4877 in patients with refractory solid tumors

Journal of Clinical Oncology ◽

10.1200/jco.2008.26.15_suppl.2501 ◽

2008 ◽

Vol 26 (15_suppl) ◽

pp. 2501-2501 ◽

Author(s):

J. R. Infante ◽

J. L. Spratlin ◽

R. Kurzrock ◽

S. G. Eckhardt ◽

H. A. Burris ◽

...

Keyword(s):

Phase I ◽

Solid Tumors ◽

Clinical Pharmacokinetic ◽

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Erratum to: Phase I clinical, pharmacokinetic, and pharmacodynamic study of KOS-862 (Epothilone D) in patients with advanced solid tumors and lymphoma

Investigational New Drugs ◽

10.1007/s10637-011-9780-8 ◽

2012 ◽

Vol 30 (6) ◽

pp. 2450-2450

Author(s):

Jason Konner ◽

Rachel N. Grisham ◽

Jae Park ◽

Owen A. O’Connor ◽

Gillian Cropp ◽

...

Keyword(s):

Phase I ◽

Solid Tumors ◽

Clinical Pharmacokinetic ◽

Advanced Solid Tumors ◽

Epothilone D ◽

Pharmacodynamic Study

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418 Phase I, clinical, pharmacokinetic and schedule dependency study of the aurora kinase inhibitor AS703569 combined with gemcitabine in patients with solid tumors

European Journal of Cancer Supplements ◽

10.1016/s1359-6349(10)72125-x ◽

2010 ◽

Vol 8 (7) ◽

pp. 133

Author(s):

E. Raymond ◽

J. Alexandre ◽

T. Besse-Hammer ◽

S. Faivre ◽

B. Longerey ◽

...

Keyword(s):

Phase I ◽

Solid Tumors ◽

Clinical Pharmacokinetic ◽

Kinase Inhibitor ◽

Aurora Kinase ◽

Aurora Kinase Inhibitor

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A Phase I Clinical, Pharmacokinetic, and Pharmacodynamic Study of Weekly or Every Three Week Ixabepilone and Daily Sunitinib in Patients with Advanced Solid Tumors

Clinical Cancer Research ◽

10.1158/1078-0432.ccr-15-2184 ◽

2016 ◽

Vol 22 (13) ◽

pp. 3209-3217 ◽

Author(s):

Alberto J. Montero ◽

Deukwoo Kwon ◽

Aurea Flores ◽

Krisztina Kovacs ◽

Jonathan C. Trent ◽

...

Keyword(s):

Phase I ◽

Solid Tumors ◽

Clinical Pharmacokinetic ◽

Advanced Solid Tumors ◽

Pharmacodynamic Study

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A phase I clinical, pharmacokinetic (PK) and pharmacodynamic (PD) evaluation of PF-00562271 targeting focal adhesion kinase (FAK) in patients (pts) with advanced solid tumors

Journal of Clinical Oncology ◽

10.1200/jco.2008.26.15_suppl.3534 ◽

2008 ◽

Vol 26 (15_suppl) ◽

pp. 3534-3534 ◽

Author(s):

L. L. Siu ◽

H. A. Burris ◽

L. R. Mileshkin ◽

D. R. Camidge ◽

S. G. Eckhardt ◽

...

Keyword(s):

Phase I ◽

Focal Adhesion Kinase ◽

Solid Tumors ◽

Clinical Pharmacokinetic ◽

Focal Adhesion ◽

Advanced Solid Tumors

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