Practical guide for interpreting and reporting cardiac PET measurements of myocardial blood flow: an Information Statement from the American Society of Nuclear Cardiology, and the Society of Nuclear Medicine and Molecular Imaging

2021 ◽  
Author(s):  
Timothy M. Bateman ◽  
Gary V. Heller ◽  
Rob Beanlands ◽  
Dennis A. Calnon ◽  
James Case ◽  
...  
Keyword(s):  
Blood Flow ◽  
Nuclear Medicine ◽  
Molecular Imaging ◽  
Nuclear Cardiology ◽  
Myocardial Blood Flow ◽  
Cardiac Pet ◽  
Practical Guide ◽  
American Society

scholarly journals GENDER DIFFERENCES IN MYOCARDIAL BLOOD FLOW IN CARDIAC PET/CT WITH REGADENOSON

2015 ◽  
Vol 65 (10) ◽  
pp. A1270
Author(s):  
Jason Allen ◽  
Steve Mason ◽  
Jon-David Ethington ◽  
Jeffrey Anderson ◽  
Raymond McCubrey ◽  
...  
Keyword(s):  
Gender Differences ◽  
Blood Flow ◽  
Myocardial Blood Flow ◽  
Cardiac Pet ◽  
Pet Ct

Abstract 12519: Age Impacts the Interpretation of Myocardial Blood Flow Values in Cardiac PET/CT

Circulation ◽  
2015 ◽  
Vol 132 (suppl_3) ◽  
Author(s):  
Hannah E Raasch ◽  
Raymond O McCubrey ◽  
Jon-David Ethington ◽  
Steve Mason ◽  
Viet T Le ◽  
...  
Keyword(s):  
Risk Factors ◽  
Blood Flow ◽  
Myocardial Blood Flow ◽  
Cardiac Pet ◽  
Flow Reserve ◽  
Age Related ◽  
Pet Ct ◽  
History Of ◽  
Global Estimates ◽  
Traditional Risk Factors

Introduction: Quantitative myocardial blood flow (MBF) obtained via Rb82 PET/CT using regadenoson provides the ability to assess ischemia through analysis of stress MBF and coronary flow reserve (CFR), the augmentation of flow expressed as a stress/rest ratio. It is unknown to what extent, if any, age-related changes in arteries (i.e. arterial stiffening, atherosclerosis) impact MBF and, thus, the interpretation of ischemia. Hypothesis: MBF values change as a function of age and impact PET interpretation. Methods: Patients who underwent PET/CT from May 2013 to April 2015 with normal perfusion images and no history of PCI or CABG were included (n=3329, 1720 women, 1498 men). Rest MBF, stress MBF, and CFR) (mL/min/g) were recorded in all vessels separated by gender and by age <60 or ≥60. Analysis was conducted on individual vessels and global estimates were calculated averaging all vessels. Estimated average median differences between age <60 and ≥60 were adjusted for traditional cardiovascular risk factors (BMI, smoking, diabetes, hypertension, hyperlipidemia, family history). Results: Effects of Age on Global MBF Adjusted for Traditional Risk Factors Conclusions: In patients ≥60 years of age with normal perfusion imaging, rest MBF increases, stress MBF decreases, and the resultant CFR is decreased, all statistically significant. This may reflect a higher fixed level of vasodilation in older vessels at rest and a more limited ability to vasodilate with stress independent of other CV risk factors. Given the increasing use of PET/CT for ischemia assessment, it is important to recognize expected MBF changes with age to decrease false positive studies and unwarranted invasive testing.

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