Amyloid deposit corresponds to technetium-99m-pyrophosphate accumulation in abdominal fat of patients with transthyretin cardiac amyloidosis

2021 ◽  
Author(s):  
Koji Takahashi ◽  
Daisuke Sasaki ◽  
Mina Yamashita ◽  
Tomoki Sakaue ◽  
Daijiro Enomoto ◽  
...  
Keyword(s):  
Cardiac Amyloidosis ◽  
Amyloid Deposit ◽  
Abdominal Fat ◽  
Technetium 99M

Diagnosis of Cardiac Transthyretin Amyloidosis by Technetium-99m Pyrophosphate Heart Scan, Confirmed by Genetic Mutations: Case Report

2021 ◽  
Vol 104 (11) ◽  
pp. 1843-1846
Keyword(s):  
Heart Failure ◽  
Case Report ◽  
Genetic Testing ◽  
Cardiac Amyloidosis ◽  
Abdominal Fat ◽  
Genetic Mutations ◽  
Fat Pad ◽  
Transthyretin Amyloidosis ◽  
Technetium 99M ◽  
Clinically Significant

Amyloid deposition in the myocardium can cause clinically significant heart failure, which is very difficult to diagnose. The present case reported presented a patient with heart failure, with suspected cause of cardiac amyloidosis, but abdominal fat pad and endomyocardial with Congo red stain biopsies were negative. Due to high suspicion of cardiac amyloidosis, a technetium-99m pyrophosphate (Tc-99m PYP) heart scan was done, which was revealed as strongly suggestive for cardiac transthyretin amyloidosis. So, the patient was sent for genetic testing, and a TTR gene mutation [c.148G>A (p.Val50Met)] was found. Keywords: Cardiac amyloidosis; Endomyocardial biopsy (EMB); Technetium-99m pyrophosphate (Tc-99m PYP) heart scan; Transthyretin amyloidosis (TTR)

scholarly journals False positive technetium-99m pyrophosphate scintigraphy in a patient with cardiac amyloidosis light chain

Medicine ◽  
2021 ◽  
Vol 100 (17) ◽  
pp. e25582
Author(s):  
Yu Zeng ◽  
Timothy J. Poterucha ◽  
Andrew J. Einstein ◽  
Qing Zhang ◽  
Yucheng Chen ◽  
...  
Keyword(s):  
Light Chain ◽  
False Positive ◽  
Cardiac Amyloidosis ◽  
Technetium 99M

Value of positive myocardial technetium-99m-pyrophosphate scintigraphy in the noninvasive diagnosis of cardiac amyloidosis

1982 ◽  
Vol 103 (4) ◽  
pp. 468-473 ◽  
Author(s):  
Theodore A. Wizenberg ◽  
Jaroslaw Muz ◽  
Young H. Sohn ◽  
Wolfram Samlowski ◽  
Arnold M. Weissler
Keyword(s):  
Cardiac Amyloidosis ◽  
Noninvasive Diagnosis ◽  
Technetium 99M

Noninvasive diagnosis of cardiac amyloidosis by technetium-99m-pyrophosphate myocardial scintigraphy

1982 ◽  
Vol 103 (4) ◽  
pp. 563-566 ◽  
Author(s):  
Samuel M. Sobol ◽  
Jerry M. Brown ◽  
Stephen R. Bunker ◽  
Jijibhoy Patel ◽  
Robert J. Lull
Keyword(s):  
Cardiac Amyloidosis ◽  
Myocardial Scintigraphy ◽  
Noninvasive Diagnosis ◽  
Technetium 99M

A patient with cardiac amyloidosis presenting a rapid increase in technetium-99m-hydroxymethylene diphosphonate accumulation

1993 ◽  
Vol 7 (4) ◽  
pp. 273-276 ◽  
Author(s):  
Takamasa Kobayashi ◽  
Michihito Sekiya ◽  
Yasushi Fujiwara ◽  
Takumi Sumimoto ◽  
Hiroshi Matsuoka ◽  
...  
Keyword(s):  
Cardiac Amyloidosis ◽  
Technetium 99M
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