A Structure–Activity Relationship Study of Imidazole-5-Carboxylic Acid Derivatives as Angiotensin II Receptor Antagonists Combining 2D and 3D QSAR Methods

Activity Relationship ◽

Angiotensin Ii Receptor ◽

Structure Activity ◽

Relationship Study ◽

2D And 3D

Comprehensive structure–activity relationship analysis of substituted 5-(biphenyl-4-ylmethyl) pyrazoles derivatives as AT1 selective angiotensin II receptor antagonists: 2D and kNNMFA QSAR approach

Medicinal Chemistry Research ◽

10.1007/s00044-012-0206-8 ◽

2012 ◽

Vol 22 (5) ◽

pp. 2124-2138 ◽

Cited By ~ 12

Author(s):

Mukesh C. Sharma ◽

D. V. Kohli

Keyword(s):

Angiotensin Ii ◽

Activity Relationship ◽

Angiotensin Ii Receptor ◽

Receptor Antagonists ◽

Relationship Analysis ◽

Structure Activity

Synthesis and Structure-Activity Relationship of a New Series of Potent Angiotensin II Receptor Antagonists: Pyrazolo(1,5-a)pyrimidine Derivatives.

Chemical and Pharmaceutical Bulletin ◽

10.1248/cpb.47.928 ◽

1999 ◽

Vol 47 (7) ◽

pp. 928-938 ◽

Cited By ~ 21

Author(s):

Takeshi SHIOTA ◽

Teruo YAMAMORI ◽

Katsunori SAKAI ◽

Mitsugu KIYOKAWA ◽

Tsunetoshi HONMA ◽

...

Keyword(s):

Angiotensin Ii ◽

Activity Relationship ◽

Angiotensin Ii Receptor ◽

Pyrimidine Derivatives ◽

Receptor Antagonists ◽

Structure Activity ◽

ChemInform Abstract: Synthesis and Structure-Activity Relationship of a New Series of Potent Angiotensin II Receptor Antagonists: Pyrazolo[1,5-a]pyrimidine Derivatives.

ChemInform ◽

10.1002/chin.199949141 ◽

2010 ◽

Vol 30 (49) ◽

pp. no-no

Author(s):

Takeshi Shiota ◽

et al. et al.

Keyword(s):

Angiotensin Ii ◽

Activity Relationship ◽

Angiotensin Ii Receptor ◽

Pyrimidine Derivatives ◽

Receptor Antagonists ◽

Structure Activity ◽

Synthesis and Structure−Activity Relationship of a New Series of Potent AT1Selective Angiotensin II Receptor Antagonists: 5-(Biphenyl-4-ylmethyl)pyrazoles

Journal of Medicinal Chemistry ◽

10.1021/jm9604383 ◽

1997 ◽

Vol 40 (4) ◽

pp. 547-558 ◽

Cited By ~ 60

Author(s):

Carmen Almansa ◽

Luis A. Gómez ◽

Fernando L. Cavalcanti ◽

Alberto F. de Arriba ◽

Julián García-Rafanell ◽

...

Keyword(s):

Angiotensin Ii ◽

Activity Relationship ◽

Angiotensin Ii Receptor ◽

Receptor Antagonists ◽

Structure Activity ◽

New non-peptide angiotensin II receptor antagonists. 2: structure - activity relationship of a series of annelated 2(1H)-pyridinones

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/s0960-894x(01)81134-3 ◽

1994 ◽

Vol 4 (1) ◽

pp. 127-132 ◽

Cited By ~ 4

Author(s):

John R. Bantick ◽

Haydn G. Beaton ◽

Sally L. Cooper ◽

Stephen Hill ◽

Simon C. Hirst ◽

...

Keyword(s):

Angiotensin Ii ◽

Activity Relationship ◽

Angiotensin Ii Receptor ◽

Receptor Antagonists ◽

Structure Activity ◽

WITHDRAWN: Comprehensive structure–activity relationship analysis of isoxazolinyl and isoxazolidinyl substituted quinazolinone derivatives as angiotensin II receptor antagonists

Journal of Saudi Chemical Society ◽

10.1016/j.jscs.2012.04.012 ◽

2012 ◽

Cited By ~ 9

Author(s):

Mukesh C. Sharma ◽

D.V. Kohli

Keyword(s):

Angiotensin Ii ◽

Activity Relationship ◽

Angiotensin Ii Receptor ◽

Receptor Antagonists ◽

Relationship Analysis ◽

Structure Activity ◽

Quinazolinone Derivatives

Molecular Modeling and Quantitative Structure—Activity Relationship Studies in Pursuit of Highly Potent Substituted Octanoamide Angiotensin II Receptor Antagonists

ACS Symposium Series - Computer-Aided Molecular Design ◽

10.1021/bk-1995-0589.ch002 ◽

1995 ◽

pp. 14-35 ◽

Cited By ~ 4

Author(s):

Donald B. Boyd ◽

Alan D. Palkowitz ◽

K. Jeff Thrasher ◽

Kenneth L. Hauser ◽

Celia A. Whitesitt ◽

...

Keyword(s):

Molecular Modeling ◽

Angiotensin Ii ◽

Quantitative Structure Activity Relationship ◽

Activity Relationship ◽

Quantitative Structure ◽

Angiotensin Ii Receptor ◽

Receptor Antagonists ◽

Structure Activity

ChemInform Abstract: Synthesis and Structure-Activity Relationship of a New Series of Potent AT1 Selective Angiotensin II Receptor Antagonists: 5-(Biphenyl- 4-ylmethyl)pyrazoles.

ChemInform ◽

10.1002/chin.199722147 ◽

2010 ◽

Vol 28 (22) ◽

pp. no-no

Author(s):

C. ALMANSA ◽

L. A. GOMEZ ◽

F. L. CAVALCANTI ◽

A. F. DE ARRIBA ◽

J. GARCIA-RAFANELL ◽

...

Keyword(s):

Angiotensin Ii ◽

Activity Relationship ◽

Angiotensin Ii Receptor ◽

Receptor Antagonists ◽

Structure Activity ◽

A comprehensive structure–activity analysis 2,3,5-trisubstituted 4,5-dihydro-4-oxo-3H-imidazo [4,5-c] pyridine derivatives as angiotensin II receptor antagonists: using 2D- and 3D-QSAR approach

Medicinal Chemistry Research ◽

10.1007/s00044-012-0040-z ◽

2012 ◽

Vol 22 (2) ◽

pp. 588-605 ◽

Cited By ~ 21

Author(s):

Mukesh C. Sharma ◽

D. V. Kohli

Keyword(s):

Angiotensin Ii ◽

3D Qsar ◽

Activity Analysis ◽

Pyridine Derivatives ◽

Angiotensin Ii Receptor ◽

Receptor Antagonists ◽

Structure Activity ◽

2D And 3D

Nonpeptide angiotensin II receptor antagonists. 2. Design, synthesis, and structure-activity relationships of 2-alkyl-4-(1H-pyrrol-l-yl)-1H-imidazole derivatives: profile of 2-propyl-1-[[2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl]-methyl]-4-[2-(trifluoroacetyl)-1H-pyrrol-1-yl]-1H-imidazole-5-carboxylic acid (CI-996)

Journal of Medicinal Chemistry ◽

10.1021/jm00068a002 ◽

1993 ◽

Vol 36 (16) ◽

pp. 2253-2265 ◽

Cited By ~ 9

Author(s):

Ila Sircar ◽

John C. Hodges ◽

John Quin ◽

Amy M. Bunker ◽

R. Thomas Winters ◽

...

Keyword(s):

Angiotensin Ii ◽

Carboxylic Acid ◽

Angiotensin Ii Receptor ◽

Receptor Antagonists ◽

Design Synthesis ◽

Structure Activity Relationships ◽

Imidazole Derivatives ◽

Structure Activity