scholarly journals Vasoformative Lesions in Mediastinal Mixed Germ Cell Tumors: an Interesting Account of Two Cases Spanning the Benign to Malignant Spectrum

2018 ◽  
Vol 9 (4) ◽  
pp. 624-628
Author(s):  
Neha Bakshi ◽  
Sukhram Bishnoi ◽  
Seema Rao
Keyword(s):  
Germ Cell ◽  
Germ Cell Tumors ◽  
Interesting Account ◽  
Mixed Germ Cell Tumors

scholarly journals Malignant Transformation of Testicular Teratoma to PNET, Adenocarcinoma, and Osteosarcoma with Complete Remission after Surgery and Combination Chemotherapy in a Young Adult Male

2018 ◽  
Vol 2018 ◽  
pp. 1-3 ◽  
Author(s):  
Angela Shaw ◽  
Miriam Morrell ◽  
Annikka Weissferdt ◽  
Andrea Hayes-Jordan ◽  
Douglas Harrison
Keyword(s):  
Germ Cell ◽  
Malignant Transformation ◽  
Germ Cell Tumors ◽  
Testicular Tumor ◽  
Metastatic Lesion ◽  
Immature Teratoma ◽  
Targeted Chemotherapy ◽  
Cell Lineages ◽  
Durable Remission ◽  
Mixed Germ Cell Tumors

Mixed germ cell tumors (GCT) with teratoma components can transform into somatic malignancies which can include histologies outside of traditional germ cell lineages. We describe a case of an 18-year-old man with a metastatic testicular GCT with both mature and immature teratoma components containing malignant transformation into multiple histologies including PNET in the primary testicular tumor and osteosarcoma in a separate pulmonary metastatic lesion. Management with targeted chemotherapy resulted in a durable remission. This is the first reported case that we know of a patient with primary PNET malignant transformation with subsequent metastatic transformation to osteosarcoma.

Combination cisplatin, vinblastine, and bleomycin chemotherapy (PVB) for malignant germ-cell tumors of the ovary.

1983 ◽  
Vol 1 (10) ◽  
pp. 645-651 ◽  
Author(s):  
R W Carlson ◽  
B I Sikic ◽  
M M Turbow ◽  
S C Ballon
Keyword(s):  
Germ Cell ◽  
Recurrent Disease ◽  
Germ Cell Tumors ◽  
Stage I ◽  
Stage Iii ◽  
Treatment Toxicity ◽  
Malignant Germ Cell Tumors ◽  
Mixed Germ Cell Tumors

Nine women with germ-cell tumors of the ovary (three endodermal sinus tumors, four immature teratomas, and two mixed germ-cell tumors) were treated with cisplatin, vinblastine, and bleomycin (PVB) chemotherapy after cytoreductive operations. Five patients were stage I, three were stage III, and one patient had recurrent disease. All nine women are alive and without evidence of disease with a median follow-up of 31 months from diagnosis and 27 months since completion of PVB. Treatment toxicity although occasionally severe was rapidly reversible.

Prognostic Impact of Laterality in Malignant Ovarian Germ Cell Tumors

2011 ◽  
Vol 21 (2) ◽  
pp. 257-262 ◽  
Author(s):  
Haider Mahdi ◽  
Sanjeev Kumar ◽  
Shelly Seward ◽  
Assaad Semaan ◽  
Ramesh Batchu ◽  
...  
Keyword(s):  
Germ Cell ◽  
Proportional Hazards ◽  
Germ Cell Tumors ◽  
Cox Proportional Hazards ◽  
Prognostic Impact ◽  
Advanced Stage ◽  
Kaplan Meier ◽  
Stage Disease ◽  
Histologic Types ◽  
Mixed Germ Cell Tumors

Objective:To compare the survival of patients with bilateral versus unilateral malignant ovarian germ cell tumors (OGCT).Methods:Patients with a diagnosis of OGCT were identified from the Surveillance, Epidemiology, and End Results Program for the period 1988 to 2006 and were divided into bilateral and unilateral subgroups. Only surgically treated patients were included. Histologic types were grouped into dysgerminoma, malignant teratoma, and mixed germ cell tumors with pure nondysgerminoma cell tumors. Statistical analysis using Wilcoxon rank sum test, Kaplan-Meier survival methods, and Cox proportional hazards regression model were performed.Results:In 1529 patients with OGCT, 1463 (95.7%) were unilateral and 66 (4.3%) were bilateral. Bilaterality was more common with dysgerminomas (6.5%) and mixed germ cell tumors with pure nondysgerminoma cell tumors (6.25%) than with immature teratomas (1.7%),P< 0.001. Most OGCT (67.3%) were stage I. Bilateral OGCT were more likely than unilateral tumors to be associated with advanced-stage disease (FIGO III and IV, 41% vs 20%,P< 0.04). Overall 5-year survival was 93.6% for unilateral OGCT and 80.7% in bilateral OGCT,P< 0.001. In multivariate analysis, bilaterality was not an independent predictor of survival when controlling for age, histology, stage, and surgical staging (hazard ratio, 1.3; 95% confidence interval, 0.7-2.5;P= 0.40).Conclusions:Compared with unilateral tumors, bilateral OGCT are more often associated with advanced-stage disease, high-risk histology, and poor survival. When other prognostic factors are accounted for, bilaterality was not an independent prognostic predictor of survival.

scholarly journals Mixed germ cell tumors: Report of two cases

2013 ◽  
Vol 6 (3) ◽  
pp. 298
Author(s):  
PradhanM Pagaro ◽  
CharusheelaR Gore ◽  
Tushar Patil ◽  
Shirish Chandanwale
Keyword(s):  
Germ Cell ◽  
Germ Cell Tumors ◽  
Mixed Germ Cell Tumors

scholarly journals Histopathological analysis of testicular tumors

2012 ◽  
Vol 2 (4) ◽  
pp. 301-304
Author(s):  
S Karki ◽  
RR Bhatta
Keyword(s):  
Germ Cell ◽  
Undescended Testis ◽  
Germ Cell Tumors ◽  
Cell Tumor ◽  
Histopathological Analysis ◽  
Testicular Tumors ◽  
Non Hodgkin Lymphoma ◽  
Pertinent Data ◽  
Testicular Lesions ◽  
Mixed Germ Cell Tumors

Background: Testicular cancers are rare in most countries. However, in many western countries its incidence has been increasing since the middle of the twentieth century. A definite geographic and racial distribution is seen in testicular tumors. The purpose of the study was to analyze the pattern and distribution of testicular cancers in one of the hospital in Nepal.Materials and methods: This was a retrospective study, in which cases were retrieved from the computer database between September 2006 and August 2011 in the department of Pathology. Pertinent data like age and histopathology of tumor were collected from the surgical pathology reports.Results: Testicular tumors were uncommon, comprising only 11.4% (8/70 cases) of all testicular lesions. Most of these tumors (50%) were seen between 4th and 5th decades. Germ cell tumors were the commonest tumors (62.5%), among which seminomas and mixed germ cell tumors were most frequently encountered, two cases each. Thirty percent of the biopsies consisted of undescended testis and none of them showed malignancy. Other tumors diagnosed were Non Hodgkin Lymphoma, leukemic infiltration and metastasis.Conclusion: Testicular tumors are uncommon in our population. As evident in other parts of the world, germ cell tumor was common in this study as well. However, unlike in Western population, no tumor was seen in undescended testis.Journal of Pathology of Nepal (2012) Vol. 2, 301-304DOI: http://dx.doi.org/10.3126/jpn.v2i4.6883

Growing teratoma syndrome: Is it a subtype of germ-cell tumors or another entity?

2017 ◽  
Vol 35 (15_suppl) ◽  
pp. e16040-e16040
Author(s):  
Mutlu Dogan ◽  
Oznur Bal ◽  
Erkan Olcucuoglu ◽  
Efnan Algin ◽  
Nurullah Zengin
Keyword(s):  
Germ Cell ◽  
Germ Cell Tumors ◽  
Primary Treatment ◽  
Salvage Chemotherapy ◽  
Growing Teratoma Syndrome ◽  
Metastatic Lesions ◽  
Interferon Α2b ◽  
Good Risk ◽  
Mixed Germ Cell Tumors

e16040 Background: Growing teratoma syndrome(GTS ) is a process presenting with growing masses despite normal tumor marker levels(TML) after chemotherapy in non-seminomatous germ cell tumors (NSGCT). Methods: GTS patients between 2000-2016 were evaluated for clinicopathological features and survival outcomes retrospectively. Results: 17 (6,4%) of 266 NSGCT had GTS. Median follow-up was 57.7 ( 13.8-132.7) months. Median age 27 (17-51) years . Most (n = 14) of them had mixed germ-cell tumors & 12 had mature/immature teratoma in primary pathology at diagnosis. Most (n = 11) of them had stage 3 disease & 10 had high TML (S1-3). 11 GTS patients had good risk NSGCT. All (n = 17) had 4 BEP(bleomycin, etoposide, cisplatin) cycles. Recurrence occured in retroperitoneum (n = 13), lung (n = 3) & brain (n = 1). They were considered as GTS since they had normal TML despite growing masses. 5 patients were referred to surgery without salvage chemotherapy and they had teratoma on postoperative surgery. 13 had surgery after salvage chemotherapy (TIP: taxane, ifosfamide, platin) but 4 had unresectable disease and they had clinical benefit with interferone α2b. Two operated patients had diffuse necrosis on pathology whereas others had documented teratoma. Median DFS was 12.3 ( 5.7-18.8) months whereas median OS was 64.8 (15.5-158) months. 3 patients had no recurrence after surgery for GTS. 9 had salvage chemotherapy (gemcitabine/oxaliplatin, TIP) for NSGCT metastatic lesions with TML elevation and 2 of them had autolog stem cell transplantation. Conclusions: GTS is rare in NSGCT, but it should be considered in NSGCT patients with both growing masses & normal TML after primary treatment approach. GTS patients surgery with resectable masses should be referred to surgery since teratoma without viable tumor seems to have less benefit from chemotherapy and/or radiotherapy. Interferon α2b might be an option in unresectable GTS.

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