scholarly journals Channel activity of mirror-image M2 proton channel of influenza A virus is blocked by achiral or chiral inhibitors

2018 ◽  
Vol 10 (3) ◽  
pp. 211-216 ◽  
Author(s):  
Qing-Yan Guo ◽  
Long-Hua Zhang ◽  
Chao Zuo ◽  
Dong-Liang Huang ◽  
Zhipeng A. Wang ◽  
...  
Keyword(s):  
Influenza A Virus ◽  
Influenza A ◽  
Mirror Image ◽  
Proton Channel ◽  
Channel Activity ◽  
M2 Proton Channel

scholarly journals Proton Channel Activity of Influenza A Virus Matrix Protein 2 Contributes to Autophagy Arrest

2015 ◽  
Vol 90 (1) ◽  
pp. 591-598 ◽  
Author(s):  
Yizhong Ren ◽  
Chufang Li ◽  
Liqiang Feng ◽  
Weiqi Pan ◽  
Liang Li ◽  
...  
Keyword(s):  
Virus Infection ◽  
Influenza A Virus ◽  
Influenza A ◽  
Matrix Protein ◽  
Proton Channel ◽  
Channel Activity ◽  
Infected Cells ◽  
Influenza A Virus Infection ◽  
M2 Proton Channel

Influenza A virus infection can arrest autophagy, as evidenced by autophagosome accumulation in infected cells. Here, we report that this autophagosome accumulation can be inhibited by amantadine, an antiviral proton channel inhibitor, in amantadine-sensitive virus infected cells or cells expressing influenza A virus matrix protein 2 (M2). Thus, M2 proton channel activity plays a role in blocking the fusion of autophagosomes with lysosomes, which might be a key mechanism for arresting autophagy.

scholarly journals Asp44 Stabilizes the Trp41 Gate of the M2 Proton Channel of Influenza A Virus

Structure ◽  
2013 ◽  
Vol 21 (11) ◽  
pp. 2033-2041 ◽  
Author(s):  
Chunlong Ma ◽  
Giacomo Fiorin ◽  
Vincenzo Carnevale ◽  
Jun Wang ◽  
Robert A. Lamb ◽  
...  
Keyword(s):  
Influenza A Virus ◽  
Influenza A ◽  
Proton Channel ◽  
M2 Proton Channel

scholarly journals Pharmacological Relevant Amantadine Binding Site is in the Pore of Influenza a Virus M2 Proton Channel

2010 ◽  
Vol 98 (3) ◽  
pp. 539a
Author(s):  
Chunlong Ma ◽  
Yuki Ohigashi ◽  
Xianghong Jing ◽  
Robert A. Lamb ◽  
Lawrence H. Pinto
Keyword(s):  
Binding Site ◽  
Influenza A Virus ◽  
Influenza A ◽  
Proton Channel ◽  
M2 Proton Channel

scholarly journals Structure and mechanism of the M2 proton channel of influenza A virus

Nature ◽  
2008 ◽  
Vol 451 (7178) ◽  
pp. 591-595 ◽  
Author(s):  
Jason R. Schnell ◽  
James J. Chou
Keyword(s):  
Influenza A Virus ◽  
Influenza A ◽  
Proton Channel ◽  
M2 Proton Channel

scholarly journals Exploring Organosilane Amines as Potent Inhibitors and Structural Probes of Influenza A Virus M2 Proton Channel

2011 ◽  
Vol 133 (35) ◽  
pp. 13844-13847 ◽  
Author(s):  
Jun Wang ◽  
Chunlong Ma ◽  
Yibing Wu ◽  
Robert A. Lamb ◽  
Lawrence H. Pinto ◽  
...  
Keyword(s):  
Influenza A Virus ◽  
Influenza A ◽  
Proton Channel ◽  
M2 Proton Channel ◽  
Structural Probes

scholarly journals Discovery of Spiro-Piperidine Inhibitors and Their Modulation of the Dynamics of the M2 Proton Channel from Influenza A Virus

2009 ◽  
Vol 131 (23) ◽  
pp. 8066-8076 ◽  
Author(s):  
Jun Wang ◽  
Sarah D. Cady ◽  
Victoria Balannik ◽  
Lawrence H. Pinto ◽  
William F. DeGrado ◽  
...  
Keyword(s):  
Influenza A Virus ◽  
Influenza A ◽  
Proton Channel ◽  
M2 Proton Channel

scholarly journals Proton and cation transport activity of the M2 proton channel from influenza A virus

2010 ◽  
Vol 107 (35) ◽  
pp. 15409-15414 ◽  
Author(s):  
T. Leiding ◽  
J. Wang ◽  
J. Martinsson ◽  
W. F. DeGrado ◽  
S. P. Arskold
Keyword(s):  
Influenza A Virus ◽  
Influenza A ◽  
Cation Transport ◽  
Proton Channel ◽  
Transport Activity ◽  
M2 Proton Channel
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