Quantitative assessment of the association between glutathione S-transferase P1 Ile105Val polymorphism and bladder cancer risk

Tumor Biology ◽  
2013 ◽  
Vol 34 (3) ◽  
pp. 1651-1657 ◽  
Author(s):  
Zhenlong Wang ◽  
Li Xue ◽  
Tie Chong ◽  
Hecheng Li ◽  
Haiwen Chen ◽  
...  
2013 ◽  
Vol 11 (1) ◽  
pp. 58 ◽  
Author(s):  
Yeqing Mao ◽  
Xin Xu ◽  
Yiwei Lin ◽  
Hong Chen ◽  
Jian Wu ◽  
...  

2005 ◽  
Vol 20 (1) ◽  
pp. 69-72 ◽  
Author(s):  
A.A. Saad ◽  
P.J. O'Connor ◽  
M.H. Mostafa ◽  
N.E. Metwalli ◽  
D.P. Cooper ◽  
...  

2005 ◽  
Vol 20 (1) ◽  
pp. 69-72 ◽  
Author(s):  
A.A. Saad ◽  
P.J. O'Connor ◽  
M.H. Mostafa ◽  
N.E. Metwalli ◽  
D.P. Cooper ◽  
...  

Previous studies suggest that bladder cancer risk may vary with GST genotype but these results are inconsistent. The aim of this study was to explore whether GSTM1, GSTT1 and GSTP polymorphisms were associated with increased bladder cancer risk in an Egyptian population. GSTM1, GSTT1 and GSTP1 genotype frequencies were determined in bladder cancer cases (n=72) and healthy controls with no history of malignancies (n=82) using PCR-based techniques. The GSTT1*2 genotype was particularly associated with increased risk (OR 2.71, 95%CI 1.27–5.73) and the GSTM1*2 genotype to a lesser extent (OR 1.63, 95%CI 0.85–3.10). 18.1% of cases but only 7.3% of controls were GSTP1*B*B homozygotes (OR 2.38, 95%CI 0.83–6.87). The presence of two or more a priori at-risk genotypes was associated with increased bladder cancer risk (OR 2.42; 95%CI 1.47–3.97). These results suggest that polymorphisms in the GST genes are associated with increased risk of bladder cancer among Egyptians.


Tumor Biology ◽  
2013 ◽  
Vol 35 (2) ◽  
pp. 1203-1209 ◽  
Author(s):  
Chuan Liu ◽  
Qinghua Yin ◽  
Jianbing Hu ◽  
Jie Weng ◽  
Yajie Wang

2009 ◽  
Vol 10 (1) ◽  
pp. 59-68 ◽  
Author(s):  
Fang-fang Zeng ◽  
Sheng-yuan Liu ◽  
Wen Wei ◽  
Song-po Yao ◽  
Shui Zhu ◽  
...  

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