An All-Digital Low-Noise Switching DC–DC Buck Converter Based on a Multi-sampling Frequency Delta-Sigma Modulation with Enhanced Light-Load Efficiency

2019 ◽  
Vol 45 (3) ◽  
pp. 1411-1419
Author(s):  
Hussain A. Alzaher ◽  
Mohammad K. Alghamdi

Author(s):  
Jiann-Jong Chen ◽  
Yuh-Shyan Hwang ◽  
Yitsen Ku ◽  
Jian-An Chen ◽  
Chien-Hung Lai


2018 ◽  
Vol 65 (9) ◽  
pp. 6860-6869 ◽  
Author(s):  
Jiann-Jong Chen ◽  
Yuh-Shyan Hwang ◽  
Chih-Shiun Jheng ◽  
Yi-Tsen Ku ◽  
Cheng-Chieh Yu


Author(s):  
Bo-Han Hwang ◽  
Jay-Ann Yo ◽  
Jiann-Jong Chen ◽  
Yuh-Shyan Hwang ◽  
Cheng-Chieh Yu


2016 ◽  
Vol E99.B (5) ◽  
pp. 1087-1092 ◽  
Author(s):  
Takashi MAEHATA ◽  
Suguru KAMEDA ◽  
Noriharu SUEMATSU


2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Justin Y. Lee ◽  
Britney Nguyen ◽  
Carlos Orosco ◽  
Mark P. Styczynski

Abstract Background The topology of metabolic networks is both well-studied and remarkably well-conserved across many species. The regulation of these networks, however, is much more poorly characterized, though it is known to be divergent across organisms—two characteristics that make it difficult to model metabolic networks accurately. While many computational methods have been built to unravel transcriptional regulation, there have been few approaches developed for systems-scale analysis and study of metabolic regulation. Here, we present a stepwise machine learning framework that applies established algorithms to identify regulatory interactions in metabolic systems based on metabolic data: stepwise classification of unknown regulation, or SCOUR. Results We evaluated our framework on both noiseless and noisy data, using several models of varying sizes and topologies to show that our approach is generalizable. We found that, when testing on data under the most realistic conditions (low sampling frequency and high noise), SCOUR could identify reaction fluxes controlled only by the concentration of a single metabolite (its primary substrate) with high accuracy. The positive predictive value (PPV) for identifying reactions controlled by the concentration of two metabolites ranged from 32 to 88% for noiseless data, 9.2 to 49% for either low sampling frequency/low noise or high sampling frequency/high noise data, and 6.6–27% for low sampling frequency/high noise data, with results typically sufficiently high for lab validation to be a practical endeavor. While the PPVs for reactions controlled by three metabolites were lower, they were still in most cases significantly better than random classification. Conclusions SCOUR uses a novel approach to synthetically generate the training data needed to identify regulators of reaction fluxes in a given metabolic system, enabling metabolomics and fluxomics data to be leveraged for regulatory structure inference. By identifying and triaging the most likely candidate regulatory interactions, SCOUR can drastically reduce the amount of time needed to identify and experimentally validate metabolic regulatory interactions. As high-throughput experimental methods for testing these interactions are further developed, SCOUR will provide critical impact in the development of predictive metabolic models in new organisms and pathways.



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