The dual role of tumor necrosis factor-alpha (TNF-α) in breast cancer: molecular insights and therapeutic approaches

2020 ◽  
Vol 43 (1) ◽  
pp. 1-18 ◽  
Author(s):  
Daniel Cruceriu ◽  
Oana Baldasici ◽  
Ovidiu Balacescu ◽  
Ioana Berindan-Neagoe
Keyword(s):  
Breast Cancer ◽  
Tumor Necrosis Factor ◽  
Tumor Necrosis Factor Alpha ◽  
Tumor Necrosis ◽  
Therapeutic Approaches ◽  
Necrosis Factor Alpha ◽  
Tnf Α ◽  
Factor Alpha ◽  
Necrosis Factor

scholarly journals Serum levels of tumor necrosis factor -alpha and hsCRP in patients with breast cancer and correlation with histological parameters

2015 ◽  
Vol 6 (6) ◽  
pp. 6-10
Author(s):  
Anisha Sharma ◽  
Binita Goswami ◽  
Nikhil Gupta ◽  
Baidarbhi Chakraborty
Keyword(s):  
Breast Cancer ◽  
Tumor Necrosis Factor ◽  
Tumor Necrosis Factor Alpha ◽  
Tumor Necrosis ◽  
Tnm Staging ◽  
Lymph Node Status ◽  
Necrosis Factor Alpha ◽  
Tnf Α ◽  
Factor Alpha ◽  
Necrosis Factor

Background: Breast cancer is now the second most commonly cancer diagnosed in women after cervical cancer in India. Presentation at late stage further aggravates the problem. The outcome of breast cancer is usually determined by multiple factors.Aims and Objectives:This study was designed with the aim to investigate any correlation between serum tumor necrosis factor alpha and hsCRP in breast cancer with histological parameters of tumor behavior. Materials and Methods: A total of 30 histological confirmed cases of locally advanced breast cancer were enrolled for study. Total duration of study was two years. HsCRP was determined by solid phase direct sandwich ELISA method (Diaclone, France).Similarly TNF-α was also determined by Enzyme-linked immunosorbent method. Three-dimensional tumor size was determined radiologically through mammography. CT scan and MRI scan were taken at the time of diagnosis to detect metastasis. The data on tumor size, estrogen receptors status, lymph node status and TNM staging were reviewed and recorded. Results: Levels of TNF-α and hsCRP in patients with more advanced TNM staging, more advanced lymph node status and high histological grade were significantly raised. Similarly, their levels were significantly raised with increasing grade of adipose tissue invasion. Levels of TNF-α and hs CRP were also significantly raised in patients with estrogen receptor status positive whereas increase in levels of these markers was not significant in progesterone receptor status positive. Conclusion: Preoperative evaluation of tumor necrosis factor alpha and high sensitivity C-reactive protein may be valuable parameters for reflecting the severity of invasive breast cancer.DOI: http://dx.doi.org/10.3126/ajms.v6i6.12714 Asian Journal of Medical Sciences Vol.6(6) 2015 6-10

scholarly journals Critical Role for Tumor Necrosis Factor Alpha in Controlling the Number of Lumenal Pathogenic Bacteria and Immunopathology in Infectious Colitis

2001 ◽  
Vol 69 (11) ◽  
pp. 6651-6659 ◽  
Author(s):  
Nathalie S. Gonçalves ◽  
Marjan Ghaem-Maghami ◽  
Giovanni Monteleone ◽  
Gad Frankel ◽  
Gordon Dougan ◽  
...  
Keyword(s):  
Tumor Necrosis Factor ◽  
Tumor Necrosis Factor Alpha ◽  
Tumor Necrosis ◽  
Interleukin 12 ◽  
Necrosis Factor Alpha ◽  
Infectious Colitis ◽  
Tnf Α ◽  
Factor Alpha ◽  
Necrosis Factor

ABSTRACT Infection of mice with the intestinal bacterial pathogenCitrobacter rodentium results in colonic mucosal hyperplasia and a local Th1 inflammatory response similar to that seen in mouse models of inflammatory bowel disease. In these latter models, and in patients with Crohn's disease, neutralization of tumor necrosis factor alpha (TNF-α) is of therapeutic benefit. Since there is no information on the role of TNF-α in either immunity to noninvasive bacterial pathogens or on the role of TNF-α in the immunopathology of infectious colitis, we investigated C. rodentiuminfection in TNFRp55−/− mice. In TNFRp55−/−mice, there were higher colonic bacterial burdens, but the organisms were cleared at the same rate as C57BL/6 mice, showing that TNF-α is not needed for protective antibacterial immunity. The most striking feature of infection in TNFRp55−/−mice, however, was the markedly enhanced pathology, with increased mucosal weight and thickness, increased T-cell infiltrate, and a markedly greater mucosal Th1 response. Interleukin-12 p40 transcripts were markedly elevated in C. rodentium-infected TNFRp55−/− mice, and this was associated with enhanced mucosal STAT4 phosphorylation. TNF-α is not obligatory for protective immunity to C. rodentium in mice; however, it appears to play some role in downregulating mucosal pathology and Th1 immune responses.

scholarly journals Association of tumor necrosis factor-alpha -308 G/A and -238 G/A polymorphism with diabetic retinopathy: a systematic review and updated meta-analysis.

2020 ◽  
Author(s):  
Wenna Gao ◽  
Ruilin Zhu ◽  
liu yang
Keyword(s):  
Diabetic Retinopathy ◽  
Tumor Necrosis Factor ◽  
Tumor Necrosis Factor Alpha ◽  
Tumor Necrosis ◽  
Meta Analysis ◽  
Entire Group ◽  
Necrosis Factor Alpha ◽  
Tnf Α ◽  
Factor Alpha ◽  
Necrosis Factor

Background: Mounting evidence has suggested tumor necrosis factor-alpha (TNF-α) can promote the development of diabetic retinopathy (DR), and TNF-α gene variants may influence DR risk. However, the results are quite different. Objectives: To comprehensively address this issue, we performed the meta-analysis to evaluate the association of TNF-α-308 G/A and -238 G/A polymorphism with DR. Method: Data were retrieved in a systematic manner and analyzed using STATA Statistical Software. Crude odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess the strength of associations. Allelic and genotypic comparisons between cases and controls were evaluated. Results: For the TNF-α-308 G/A polymorphism, overall analysis suggested a marginal association with DR [the OR(95%CI) of (GA versus GG), (GA + AA) versus GG, and (A versus G) are 1.21(1.04, 1.41), 1.20(1.03, 1.39), and 1.14(1.01, 1.30), respectively]. And the subgroup analysis indicated an enhanced association among the European population. For the TNF-α-238 G/A polymorphism, there was mild correlation in the entire group [the OR(95%CI) of (GA versus GG) is 1.55(1.14,2.11) ], which was strengthened among the Asian population. Conclusion: The meta-analysis suggested that -308 A and -238 A allele in TNF-α gene potentially increased DR risk and showed a discrepancy in different ethnicities.

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