Effects of Intracoronary Nicorandil on Myocardial Microcirculation and Clinical Outcomes in Patients with Acute Myocardial Infarction: A Meta-Analysis of Randomized Controlled Trials

2019 ◽  
Vol 20 (2) ◽  
pp. 191-198 ◽  
Author(s):  
Liye Shi ◽  
Ling Chen ◽  
Guoxian Qi ◽  
Wen Tian ◽  
Shijie Zhao
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Randomized Controlled Trials ◽  
Clinical Outcomes ◽  
Meta Analysis ◽  
Controlled Trials ◽  
Myocardial Microcirculation ◽  
Randomized Controlled

Intracoronary Thrombolysis in Patients With ST-Segment Elevation Myocardial Infarction: A Meta-Analysis of Randomized Controlled Trials

Angiology ◽  
2021 ◽  
pp. 000331972199503
Author(s):  
Ling Chen ◽  
Liye Shi ◽  
Wen Tian ◽  
Shijie Zhao
Keyword(s):  
Myocardial Infarction ◽  
Randomized Controlled Trials ◽  
Meta Analysis ◽  
Controlled Trials ◽  
St Segment Elevation ◽  
Myocardial Microcirculation ◽  
Segment Elevation Myocardial Infarction ◽  
Randomized Controlled ◽  
St Segment ◽  
Intracoronary Thrombolysis

Background: The effects of intracoronary (IC) thrombolysis therapy in patients with ST-segment elevation myocardial infarction (STEMI) receiving primary percutaneous coronary intervention (PPCI) remain unclear. Methods: The meta-analysis was conducted according to the PRISMA statement. All relevant studies were identified by searching the PubMed, EMBASE, Cochrane Library, and Web of Science, with no time or language limitation. The pooled risk ratio (RR) and weighted mean difference (WMD) with a 95% CI were calculated. Results: Nine randomized controlled trials involving a total of 1341 patients were included. Compared with the control group, IC thrombolysis in patients with STEMI could reduce the incidence of major adverse cardiac events (MACE; RR 0.632, 95% CI, 0.474-0.843, P = .002) and improve left ventricular ejection fraction (RR 0.343, 95% CI, 0.178-0.509, P < .001) and myocardial microcirculation. However, there was no difference noted in the mortality (RR 0.759, 95% CI, 0.347-1.661, P = .490). The incidence rate of major bleeding and minor bleeding was comparable between the 2 groups. Conclusions: Intracoronary thrombolysis was associated with improved MACE and myocardial microcirculation in patients with STEMI having PPCI, though it failed to improve mortality.

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