Prediction of Drug–Drug Interactions Between Opioids and Overdosed Benzodiazepines Using Physiologically Based Pharmacokinetic (PBPK) Modeling and Simulation

Physiologically Based Pharmacokinetic (PBPK) Modeling and Simulation Approaches: A Systematic Review of Published Models, Applications, and Model Verification

Drug Metabolism and Disposition ◽

10.1124/dmd.115.065920 ◽

2015 ◽

Vol 43 (11) ◽

pp. 1823-1837 ◽

Cited By ~ 170

Author(s):

Jennifer E. Sager ◽

Jingjing Yu ◽

Isabelle Ragueneau-Majlessi ◽

Nina Isoherranen

Keyword(s):

Systematic Review ◽

Modeling And Simulation ◽

Model Verification ◽

Pbpk Modeling ◽

Impact of acute fat mobilisation on the pharmacokinetics of the highly fat distributed compound TAK-357, investigated by physiologically based pharmacokinetic (PBPK) modeling and simulation

Biopharmaceutics & Drug Disposition ◽

10.1002/bdd.2075 ◽

2017 ◽

Vol 38 (6) ◽

pp. 373-380 ◽

Cited By ~ 1

Author(s):

Akihiko Goto ◽

Yoshihiko Tagawa ◽

Yuu Moriya ◽

Sho Sato ◽

Yoshiyuki Furukawa ◽

...

Keyword(s):

Modeling And Simulation ◽

Pbpk Modeling ◽

Leveraging Physiologically-Based Pharmacokinetic (PBPK) Modeling and Experimental Data to Guide Dosing Modification of CYP3A-Mediated Drug-Drug Interactions (DDIs) in the Pediatric Population

Drug Metabolism and Disposition ◽

10.1124/dmd.120.000318 ◽

2021 ◽

pp. DMD-AR-2020-000318

Author(s):

Sara N. Salerno ◽

Fernando O. Carreño ◽

Andrea N. Edginton ◽

Michael Cohen-Wolkowiez ◽

Daniel Gonzalez

Keyword(s):

Experimental Data ◽

Drug Interactions ◽

Pediatric Population ◽

Pbpk Modeling ◽

Physiologically based pharmacokinetic (PBPK) modeling and simulation in neonatal drug development: how clinicians can contribute

Expert Opinion on Drug Metabolism & Toxicology ◽

10.1080/17425255.2019.1558205 ◽

2018 ◽

Vol 15 (1) ◽

pp. 25-34 ◽

Cited By ~ 8

Author(s):

Anne Smits ◽

Pieter De Cock ◽

An Vermeulen ◽

Karel Allegaert

Keyword(s):

Drug Development ◽

Modeling And Simulation ◽

Pbpk Modeling ◽

Report from the EMA workshop on qualification and reporting of physiologically based pharmacokinetic (PBPK) modeling and simulation

CPT Pharmacometrics & Systems Pharmacology ◽

10.1002/psp4.12166 ◽

2017 ◽

Vol 6 (2) ◽

pp. 71-72 ◽

Cited By ~ 11

Author(s):

P Zhao

Keyword(s):

Modeling And Simulation ◽

Pbpk Modeling ◽

Influence of body composition on disposition of the highly fat distributed compound as analysed by physiologically based pharmacokinetic (PBPK) modeling and simulation

Biopharmaceutics & Drug Disposition ◽

10.1002/bdd.2106 ◽

2017 ◽

Vol 38 (9) ◽

pp. 543-552

Author(s):

Akihiko Goto ◽

Yoshihiko Tagawa ◽

Yuu Moriya ◽

Sho Sato ◽

Masami Yamamoto ◽

...

Keyword(s):

Body Composition ◽

Modeling And Simulation ◽

Pbpk Modeling ◽

Physiologically-Based Pharmacokinetic Modeling and Simulation to Assess Potential Cytochrome P450 3A4 and Transporter-Mediated Drug−drug Interactions with Prucalopride as Victim

10.26226/morressier.57d6b2b9d462b8028d88ea6f ◽

2016 ◽

Author(s):

Aiqun Li

Keyword(s):

Cytochrome P450 ◽

Drug Interactions ◽

Modeling And Simulation ◽

Pharmacokinetic Modeling ◽

Cytochrome P450 3A4 ◽

Physiologically Based Pharmacokinetic Modeling ◽

Pharmacokinetic Modeling And Simulation

Physiologically Based ◽

Extended Clearance Concept and physiologically-based pharmacokinetic (PBPK) modeling for predicting transporter/enzyme-mediated complex drug-drug interactions based on in vitro measured parameters

Proceedings for Annual Meeting of The Japanese Pharmacological Society ◽

10.1254/jpssuppl.wcp2018.0_sy31-1 ◽

2018 ◽

Vol WCP2018 (0) ◽

pp. SY31-1

Author(s):

Yuichi Sugiyama

Keyword(s):

Drug Interactions ◽

Pbpk Modeling ◽

Physiologically Based ◽

Clearance Concept ◽

Complex Drug

Physiologically Based Pharmacokinetic (PBPK) Modeling and Simulation of Lornoxicam to Develop Personalized Drug Optimization regarding to CYP2C9 Genetic Polymorphism

The FASEB Journal ◽

10.1096/fasebj.2020.34.s1.01862 ◽

2020 ◽

Vol 34 (S1) ◽

pp. 1-1

Author(s):

CHANGKEUN CHO ◽

CHANGWOO LIM ◽

KYUNGYUL OH ◽

HYOBIN SHIN ◽

EUIHYUN JUNG ◽

...

Keyword(s):

Genetic Polymorphism ◽

Modeling And Simulation ◽

Pbpk Modeling ◽

Physiologically Based ◽

Drug Optimization

Physiologically Based Pharmacokinetic (PBPK) Modeling of Pitavastatin and Atorvastatin to Predict Drug-Drug Interactions (DDIs)

European Journal of Drug Metabolism and Pharmacokinetics ◽

10.1007/s13318-016-0383-9 ◽

2016 ◽

Vol 42 (4) ◽

pp. 689-705 ◽

Cited By ~ 23

Author(s):

Peng Duan ◽

Ping Zhao ◽

Lei Zhang

Keyword(s):

Drug Interactions ◽

Pbpk Modeling ◽