scholarly journals Status Epilepticus and Delirium Associated with Ertapenem in a Very Elderly Patient with Chronic Kidney Disease and Silent Ischaemic Cerebrovascular Disease

2015 ◽  
Vol 2 (1) ◽  
Author(s):  
Huimin Lin ◽  
Samuel T. H. Chew
Open Medicine ◽  
2010 ◽  
Vol 5 (3) ◽  
pp. 329-337 ◽  
Author(s):  
Ligia Petrica ◽  
Maxim Petrica ◽  
Gluhovschi Gheorghe ◽  
Matcau Liviu ◽  
Gadalean Florica ◽  
...  

AbstractCardiovascular complications, including stroke, may be attributed the highest rate of morbidity and mortality in patients with chronic kidney disease (CKD). The aim of our study was to evaluate the prevalence of CKD in patients with symptomatic ischaemic cerebrovascular disease and to establish of whether CKD may define a particular risk pattern of cerebral vessels modifications in this category of patients. The prevalence of CKD was evaluated in 590 consecutive patients with symptomatic ischaemic cerebrovascular disease admitted to a department of neurology. The types of stroke, the vascular territories, the vascular modifications and the haemodynamic changes (resistance index- RI) found by neurosonology (extracranial and transcranial Doppler ultrasound) were analysed in relation to classic and non-classic cerebrovascular risk factors, as well as to stages of CKD (defined by estimated glomerular filtration rate-eGFR-MDRD4 formula-K/DOQI 2002). The prevalence of CKD in the studied patients was 70.84%. Atherosclerosis in a diffuse pattern was detected in 79.7% of CKD patients, while carotid artery stenoses were found in 10% of cases, occlusions- 5.3%, stenoses + occlusions-1.2%, and multiple stenoses- 3.8% of cases. The RI evaluated in the internal carotid arteries correlated with fibrinogen(P<0.0001) and GFR(P<0.0001), while IR in the middle cerebral arteries correlated with fibrinogen(P<0.05), C-reactive protein(P<0.0001), and GFR(P<0.0001). There is a strong relation between symptomatic cerebrovascular disease and CKD, a fact demonstrated by the increased prevalence of CKD in these patients and by the severity of the cerebral vessels lesions.


2013 ◽  
Vol 23 (3) ◽  
pp. 177-188 ◽  
Author(s):  
AH Abdelhafiz ◽  
C Bailey ◽  
J Russell ◽  
M El Nahas

SummaryChronic kidney disease prevalence will continue to rise due to increased life expectancy and population ageing. It is likely that the decline in glomerular filtration rate with increasing age represents a renal manifestation of widespread vascular disease. In addition to its associated cardiovascular risk, chronic kidney disease in older people is associated with increased prevalence of geriatric syndromes such as functional and cognitive decline, which lead to disability and frailty. Competing risks for mortality, because of the co-existence of multiple co-morbidities in old age, means that the majority of older people with chronic kidney disease will not progress to end-stage renal disease. Management of chronic kidney disease in older people is complex and an individualized and holistic, rather than disease-orientated, approach is necessary, which takes into account patients’ priorities and wishes, especially frail and very elderly populations with multiple co-morbidities.


Drugs & Aging ◽  
2009 ◽  
Vol 26 (6) ◽  
pp. 457-468 ◽  
Author(s):  
Mario Cozzolino ◽  
Maurizio Gallieni ◽  
Sabina Pasho ◽  
Giuditta Fallabrino ◽  
Paola Ciceri ◽  
...  

Background: Delirium is the condition of an acute confusional state that disturbs both alertness and cognition. The problem is likely to happen with general internal medicine patients admitted in general wards. Objective: To identify delirium cases in the internal medicine In-Patient Department (IPD) by using the Thai Confusion Assessment Method for intensive care unit (CAM-ICU). Materials and Methods: The cross-sectional study was conducted between February and December 2018. The Thai version of the CAM-ICU was used as the evaluation form to detect delirium. The patients admitted to the IPD of internal medicine were freely randomized to be volunteers. Demographic data, systemic illnesses, neurology diseases, and current medications were recorded. Results: Three hundred fifty-six patients, 175 males (49.2%) and 181 females (50.8%), were included in the present study. The mean age was 61.52 years old. The development of acute confusion was significant in patients 50 years old and older (p<0.001). Multivariate analysis indicated the significant effect of substance abuse (p<0.05), chronic kidney disease (p<0.05), cerebrovascular disease (p<0.05), benzodiazepine usage (p<0.05), alcohol abuse (p<0.05), and age 50 years or older (p<0.001). Sixty-nine cases met the Thai CAM-ICU criteria for delirium of CAM-ICU, but the interns did not notice this problem (p<0.001). Conclusion: Chronic kidney disease, cerebrovascular disease, substance abuse, benzodiazepine use, alcohol abuse, and age 50 years or older are the factors associated with delirium in the present study. Hypoactive delirium is underdiagnosed by doctors but revealed by using CAM-ICU. Keywords: Delirium, CAM-ICU, Hypoactive delirium, RASS


2017 ◽  
Vol 4 (2) ◽  
pp. 53
Author(s):  
Maathury Sivapalan ◽  
Malintha Chamalee Wickramasinghe ◽  
Rathypriya Balarupan ◽  
Jegarajah Indrakumar

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