Tensional Homeostasis

2012 ◽  
Keyword(s):  
Tensional Homeostasis

scholarly journals Tensional Homeostasis in Single Fibroblasts

2014 ◽  
Vol 107 (1) ◽  
pp. 146-155 ◽  
Author(s):  
Kevin D. Webster ◽  
Win Pin Ng ◽  
Daniel A. Fletcher
Keyword(s):  
Tensional Homeostasis

scholarly journals Cell–matrix interaction during strain-dependent remodelling of simulated collagen networks

2016 ◽  
Vol 6 (1) ◽  
pp. 20150069 ◽  
Author(s):  
Lazarina Gyoneva ◽  
Carley B. Hovell ◽  
Ryan J. Pewowaruk ◽  
Kevin D. Dorfman ◽  
Yoav Segal ◽  
...  
Keyword(s):  
Mechanical Stability ◽  
Theoretical Work ◽  
Collagen Fibres ◽  
Tissue Remodelling ◽  
Cell Network ◽  
Fibre Network ◽  
Cell Matrix ◽  
A Cell ◽  
Tensional Homeostasis ◽  
Strain Dependent

The importance of tissue remodelling is widely accepted, but the mechanism by which the remodelling process occurs remains poorly understood. At the tissue scale, the concept of tensional homeostasis, in which there exists a target stress for a cell and remodelling functions to move the cell stress towards that target, is an important foundation for much theoretical work. We present here a theoretical model of a cell in parallel with a network to study what factors of the remodelling process help the cell move towards mechanical stability. The cell-network system was deformed and kept at constant stress. Remodelling was modelled by simulating strain-dependent degradation of collagen fibres and four different cases of collagen addition. The model did not lead to complete tensional homeostasis in the range of conditions studied, but it showed how different expressions for deposition and removal of collagen in a fibre network can interact to modulate the cell's ability to shield itself from an imposed stress by remodelling the surroundings. This study also showed how delicate the balance between deposition and removal rates is and how sensitive the remodelling process is to small changes in the remodelling rules.

Crimp length decreases in lax tendons due to cytoskeletal tension, but is restored with tensional homeostasis

2016 ◽  
Vol 35 (3) ◽  
pp. 573-579 ◽  
Author(s):  
Michael Lavagnino ◽  
Andrew E. Brooks ◽  
Anna N. Oslapas ◽  
Keri L. Gardner ◽  
Steven P. Arnoczky
Keyword(s):  
Cytoskeletal Tension ◽  
Tensional Homeostasis

Tensional Homeostasis

2008 ◽  
pp. 2937-2940
Author(s):  
Inkyung Kang ◽  
Valerie M. Weaver
Keyword(s):  
Tensional Homeostasis

scholarly journals Mechanical stimulation of single cells by reversible host-guest interactions in 3D microscaffolds

2020 ◽  
Vol 6 (39) ◽  
pp. eabc2648
Author(s):  
Marc Hippler ◽  
Kai Weißenbruch ◽  
Kai Richler ◽  
Enrico D. Lemma ◽  
Masaki Nakahata ◽  
...  
Keyword(s):  
Single Cells ◽  
Three Dimensional ◽  
Stimuli Responsive ◽  
Traction Forces ◽  
Set Point ◽  
Cellular Processes ◽  
Laser Lithography ◽  
Cross Links ◽  
Tensional Homeostasis ◽  
Myosin Motors

Many essential cellular processes are regulated by mechanical properties of their microenvironment. Here, we introduce stimuli-responsive composite scaffolds fabricated by three-dimensional (3D) laser lithography to simultaneously stretch large numbers of single cells in tailored 3D microenvironments. The key material is a stimuli-responsive photoresist containing cross-links formed by noncovalent, directional interactions between β-cyclodextrin (host) and adamantane (guest). This allows reversible actuation under physiological conditions by application of soluble competitive guests. Cells adhering in these scaffolds build up initial traction forces of ~80 nN. After application of an equibiaxial stretch of up to 25%, cells remodel their actin cytoskeleton, double their traction forces, and equilibrate at a new dynamic set point within 30 min. When the stretch is released, traction forces gradually decrease until the initial set point is retrieved. Pharmacological inhibition or knockout of nonmuscle myosin 2A prevents these adjustments, suggesting that cellular tensional homeostasis strongly depends on functional myosin motors.

A Theoretical Model of Stretch-Induced Stress Fiber Remodeling

2008 ◽  
Author(s):  
Roland Kaunas
Keyword(s):  
Focal Adhesion ◽  
Focal Adhesions ◽  
Dynamic Structure ◽  
Cytoskeletal Proteins ◽  
Stress Fibers ◽  
Cell Contractility ◽  
Maximum Stretch ◽  
Tensional Homeostasis ◽  
Tractional Forces ◽  
Actin Stress Fibers

Cyclic stretching of endothelial cells (ECs), such as occurs in arteries during the cardiac cycle, induces ECs and their actin stress fibers to orient perpendicular to the direction of maximum stretch. This perpendicular alignment response is strengthened by increasing the magnitudes of stretch and cell contractility (1). The actin cytoskeleton is a dynamic structure that regulates cell shape changes and mechanical properties. It has been shown that actin stress fibers are ‘prestretched’ under normal, non-perturbed, conditions (2), consistent with the ideas of ‘prestress’ that have motivated tensegrity cell models (3). It has also been shown that ‘tractional forces’ generated by cells at focal adhesions tend to increase proportionately with increasing focal adhesion area, thus suggesting that cells tend to maintain constant the stress borne by a focal adhesion (4). By implication, this suggests that cells try to maintain constant the stress in actin stress fibers. Thus, it seems that cells reorganize or turnover cytoskeletal proteins and adhesion complexes so as to maintain constant a preferred mechanical state. Mizutani et al. (5) referred to this as cellular tensional homeostasis, although they did not suggest a model or theory to account for this dynamic process.

Focal adhesion displacement magnitude is a unifying feature of tensional homeostasis

2020 ◽  
Vol 113 ◽  
pp. 372-379 ◽  
Author(s):  
Han Xu ◽  
Stephanie Donegan ◽  
Jordan M. Dreher ◽  
Alicia J. Stark ◽  
Elizabeth P. Canović ◽  
...  
Keyword(s):  
Focal Adhesion ◽  
Tensional Homeostasis

Thermodynamic consideration of tensional homeostasis in stress fibers

2019 ◽  
Vol 2019.32 (0) ◽  
pp. 1F23
Author(s):  
Yuika UEDA ◽  
Daiki MATSUNAGA ◽  
Tsubasa S. MATSUI ◽  
Sinji DEGUCHI
Keyword(s):  
Stress Fibers ◽  
Thermodynamic Consideration ◽  
Tensional Homeostasis

scholarly journals Modeling tensional homeostasis in multicellular clusters

2016 ◽  
Vol 33 (3) ◽  
pp. e02801 ◽  
Author(s):  
Sze Nok Tam ◽  
Michael L. Smith ◽  
Dimitrije Stamenović
Keyword(s):  
Tensional Homeostasis
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