peripheral node

2011 ◽  
Keyword(s):  
Peripheral Node

peripheral node

2000 ◽  
pp. 1249-1249
Author(s):  
Martin H. Weik
Keyword(s):  
Peripheral Node

Random walk and first passage time on a weighted hierarchical network

2014 ◽  
Vol 25 (09) ◽  
pp. 1450037 ◽  
Author(s):  
Feng Zhu ◽  
Meifeng Dai ◽  
Yujuan Dong ◽  
Jie Liu
Keyword(s):  
Random Walk ◽  
First Passage Time ◽  
Passage Time ◽  
Scale Factor ◽  
Hierarchical Network ◽  
Self Similarity ◽  
First Passage ◽  
Hierarchical Networks ◽  
Average Value ◽  
Peripheral Node

This paper reports a weighted hierarchical network generated on the basis of self-similarity, in which each edge is assigned a different weight in the same scale. We studied two substantial properties of random walk: the first-passage time (FPT) between a hub node and a peripheral node and the FPT from a peripheral node to a local hub node over the network. Meanwhile, an analytical expression of the average sending time (AST) is deduced, which reflects the average value of FPT from a hub node to any other node. Our result shows that the AST from a hub node to any other node is related to the scale factor and the number of modules. We found that the AST grows sublinearly, linearly and superlinearly respectively with the network order, depending on the range of the scale factor. Our work may shed some light on revealing the diffusion process in hierarchical networks.

scholarly journals Lymphotoxin Plays a Crucial Role in the Development and Function of Nasal-Associated Lymphoid Tissue through Regulation of Chemokines and Peripheral Node Addressin

2005 ◽  
Vol 166 (1) ◽  
pp. 135-146 ◽  
Author(s):  
Xiaoyan Ying ◽  
Kee Chan ◽  
Priti Shenoy ◽  
Myriam Hill ◽  
Nancy H. Ruddle
Keyword(s):  
Crucial Role ◽  
Lymphoid Tissue ◽  
And Function ◽  
Peripheral Node

scholarly journals Sialomucin CD34 is the major L-selectin ligand in human tonsil high endothelial venules.

1995 ◽  
Vol 131 (1) ◽  
pp. 261-270 ◽  
Author(s):  
K D Puri ◽  
E B Finger ◽  
G Gaudernack ◽  
T A Springer
Keyword(s):  
Complex Mixture ◽  
Lymphocyte Homing ◽  
High Endothelial Venules ◽  
Human Tonsil ◽  
Hematopoietic Cell Line ◽  
Selectin Ligands ◽  
Selectin Ligand ◽  
Peripheral Node ◽  
Ligand Activity

Peripheral node addressin (PNAd) is a complex mixture of glycoproteins with L-selectin ligand activity that functions in lymphocyte homing. We have investigated the contribution of the sialomucin CD34 relative to other components of PNAd in lymphocyte tethering and rolling in in vitro laminar flow assays. PNAd was isolated with MECA-79 mAb-Sepharose from tonsillar stroma, and the CD34 component (PNAd,CD34+) and CD34-negative component (PNAd,CD34-) separated on CD34 mAb-Sepharose. Lymphocytes on the PNAd,CD34- fraction tether less efficiently, roll faster and are less resistant to shear detachment than on PNAd. The PNAd,CD34+ fraction constitutes about half the total functional activity. These studies show that CD34 is a major functional component of PNAd. Ligand activity in both the PNAd,CD34+ and PNAd,CD34- fractions is expressed on mucin-like domains, as shown with O-sialoglycoprotease. The CD34 component of PNAd has about four times higher tethering efficiency than total tonsillar CD34. CD34 from spleen shows no lymphocyte tethering. Although less efficient than the PNAd,CD34+ fraction from tonsil, CD34 from the KG1a hematopoietic cell line is functionally active as an L-selectin ligand despite lack of reactivity with MECA-79 mAb, which binds to a sulfation-dependent epitope. All four forms of CD34 are active in binding to E-selectin. KG1a CD34 but not spleen CD34 are active as L-selectin ligands, yet both lack MECA-79 reactivity and possess E-selectin ligand activity. This suggests that L-selectin ligands and E-selectin ligands differ in more respects than presence of the MECA-79 epitope.

scholarly journals A Novel Endothelial L-Selectin Ligand Activity in Lymph Node Medulla That Is Regulated by α(1,3)-Fucosyltransferase-IV

2003 ◽  
Vol 198 (9) ◽  
pp. 1301-1312 ◽  
Author(s):  
Christine M'Rini ◽  
Guiying Cheng ◽  
Colleen Schweitzer ◽  
Lois L. Cavanagh ◽  
Roger T. Palframan ◽  
...  
Keyword(s):  
Mrna Level ◽  
Surrogate Marker ◽  
High Endothelial Venules ◽  
Cell Homing ◽  
Selectin Ligands ◽  
Peripheral Lymph ◽  
T Cell Homing ◽  
Selectin Ligand ◽  
Peripheral Node ◽  
Ligand Activity

Lymphocytes home to peripheral lymph nodes (PLNs) via high endothelial venules (HEVs) in the subcortex and incrementally larger collecting venules in the medulla. HEVs express ligands for L-selectin, which mediates lymphocyte rolling. L-selectin counterreceptors in HEVs are recognized by mAb MECA-79, a surrogate marker for molecularly heterogeneous glycans termed peripheral node addressin. By contrast, we find that medullary venules express L-selectin ligands not recognized by MECA-79. Both L-selectin ligands must be fucosylated by α(1,3)-fucosyltransferase (FucT)-IV or FucT-VII as rolling is absent in FucT-IV+VII−/− mice. Intravital microscopy experiments revealed that MECA-79–reactive ligands depend primarily on FucT-VII, whereas MECA-79–independent medullary L-selectin ligands are regulated by FucT-IV. Expression levels of both enzymes paralleled these anatomical distinctions. The relative mRNA level of FucT-IV was higher in medullary venules than in HEVs, whereas FucT-VII was most prominent in HEVs and weak in medullary venules. Thus, two distinct L-selectin ligands are segmentally confined to contiguous microvascular domains in PLNs. Although MECA-79–reactive species predominate in HEVs, medullary venules express another ligand that is spatially, antigenically, and biosynthetically unique. Physiologic relevance for this novel activity in medullary microvessels is suggested by the finding that L-selectin–dependent T cell homing to PLNs was partly insensitive to MECA-79 inhibition.

scholarly journals The expression of proliferating cell nuclear antigen in paraffin sections of peripheral, node-negative non-small cell lung cancer

Cancer ◽  
1992 ◽  
Vol 70 (6) ◽  
pp. 1520-1527 ◽  
Author(s):  
Gabriella Fontanini ◽  
Paolo Macchiarini ◽  
Stefano Pepe ◽  
Angela Ruggievo ◽  
Michael Hardin ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Proliferating Cell Nuclear Antigen ◽  
Small Cell ◽  
Nuclear Antigen ◽  
Small Cell Lung ◽  
Paraffin Sections ◽  
Node Negative ◽  
Proliferating Cell ◽  
Peripheral Node

scholarly journals Most peripheral, node-negative, non-small-cell lung cancers have low proliferative rates and no intratumoral and peritumoral blood and lymphatic vessel invasion

1992 ◽  
Vol 104 (4) ◽  
pp. 892-899 ◽  
Author(s):  
Paolo Macchiarini ◽  
Gabriella Fontanini ◽  
James M. Hardin ◽  
Raffaele Pingitore ◽  
C. Alberto Angeletti
Keyword(s):  
Lymphatic Vessel ◽  
Small Cell ◽  
Lymphatic Vessel Invasion ◽  
Small Cell Lung ◽  
Node Negative ◽  
Lung Cancers ◽  
Vessel Invasion ◽  
Peripheral Node

Prompt elevations of PGE2 and thromboxane A2 metabolites in peripheral node efferent lymph of sheep following drainage area immunization

1989 ◽  
Vol 17 (2) ◽  
pp. 73-80 ◽  
Author(s):  
Thomas C. Moore ◽  
Charles H. Spruck ◽  
Jose L. Lami ◽  
Sami I. Said
Keyword(s):  
Thromboxane A2 ◽  
Drainage Area ◽  
Peripheral Node
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