Small doses of subcutaneous heparin in preventing postoperative deep venous thrombosis

1974 ◽  
Vol 87 (2) ◽  
pp. 261-263 ◽  
Author(s):  
A.N Nicolaides ◽  
P.A Dupont ◽  
S Desai ◽  
J.D Lewis ◽  
J.N Douglas ◽  
...  
The Lancet ◽  
1974 ◽  
Vol 304 (7875) ◽  
pp. 286-287 ◽  
Author(s):  
I. Gordon Smith ◽  
L.P. Le Quesne ◽  
J.F. Newcombe

1979 ◽  
Author(s):  
J.J.F. Belch ◽  
G.D.O. Lowe ◽  
J.G. Pollock ◽  
C.D. Forbes ◽  
C.R.M. Prentice

In a randomised double-blind controlled trial 24 patients undergoing elective aortic bifurcation graft surgery received subcutaneous calcium heparin (2, 500 u preoperatively then 5,000 u 12 hourly or 7 days) and 25 control patients received saline injections. All patients received the routine dose of intravenous sodium heparin intraoperatively. The trial was terminated because of excess bleeding complications in patients on subcutaneous heparin (8 vs. 1, p<0.05). Deep venous thrombosis was diagnosed by 125I-fibrinogen scanning in 8 control patients and 3 patients on heparin (p>0.05). In this group of patients the risk of bleeding due to subcutaneous heparin appeared to outweigh the benefit of thrombotic prophylaxis.


1983 ◽  
Vol 145 (6) ◽  
pp. 775-779 ◽  
Author(s):  
Kiyoshi Inada ◽  
Naoki Shirai ◽  
Masatomo Hayashi ◽  
Koji Matsumoto ◽  
Mitsuo Hirose

2000 ◽  
Vol 32 (4) ◽  
pp. 669-675 ◽  
Author(s):  
Marc A. Passman ◽  
Mark A. Farber ◽  
William A. Marston ◽  
Robert E. Carlin ◽  
Lewis V. Owens ◽  
...  

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