Ajmalin, a rauwolfia alkaloid for the treatment of digitoxic arrhythmias

1966 ◽  
Vol 17 (2) ◽  
pp. 227-231 ◽  
Author(s):  
Vaclav Bazika ◽  
Tzu-Wang Lang ◽  
Stanley Pappelbaum ◽  
Eliot Corday
Keyword(s):  
Rauwolfia Alkaloid

Untersuchungen �ber Rauwolfia-Alkaloid-Modelle II

1958 ◽  
Vol 88 (6) ◽  
pp. 1087-1094 ◽  
Author(s):  
Thomas N�gr�di
Keyword(s):  
Rauwolfia Alkaloid

Characterization of 2β(R)-17-O-AcetylajmaIan: Acetylesterase — a Specific Enzyme Involved in the Biosynthesis of the Rauwolfia Alkaloid Ajmaline

1987 ◽  
Vol 42 (4) ◽  
pp. 333-342 ◽  
Author(s):  
Leo Polz ◽  
Helmut Schübel ◽  
Joachim Stoekigt
Keyword(s):  
Substrate Selectivity ◽  
Specific Enzyme ◽  
Naturally Occurring ◽  
Optimum Ph ◽  
Relative Molecular Weight ◽  
Inhibition Studies ◽  
Hydrolysis Of ◽  
Activity Point ◽  
Rauwolfia Alkaloid

A novel enzyme was isolated, partially purified (217-fold) and characterized from cell suspen­sion cultures of Rauwolfia serpentina Benth. The enzyme catalyzes one of the late biochemical reactions in the biosynthesis of ajmaline by hydrolysis of 17-O-acetylated alkaloids of the ajmalan group forming the appropriate deacetylated compounds. This esterase exhibits an unusually high substrate selectivity and exclusively accepts acetylated ajmaline derivatives with the naturally occurring 2β(R)-configuration. The properties of the enzyme were determined showing an optimum pH at 7.5, an isoelectric point of pH 4.9 and a relative molecular weight of 33 ± 2 kDa. Inhibition studies of enzyme activity point to the necessity of SH-groups. The esterase seems not to be inhibited by ajmaline. the end product of the pathway. The highest enzyme activities were observed in leaves and cell suspension tissues of the tribe Rauwolfieae which are known to synthe­size ajmaline and its congeners. The specific function of the esterase in the biosynthesis of the later alkaloids was established.

Vergleichende klinische Untersuchungen �ber die Blutdruckwirkung von Hydrazinophthalazin und dem Rauwolfia-Alkaloid Reserpin

1954 ◽  
Vol 32 (37-38) ◽  
pp. 930-935 ◽  
Author(s):  
K. K�hns ◽  
R. Djuranovic ◽  
C. Gehrs ◽  
K. K�ppen
Keyword(s):  
Rauwolfia Alkaloid

Vereinfachte Rauwolfia-Alkaloid-Modelle, I. Mitteil.: Über Tetrahydro-4-carbolin- und Hexadehydro-yohimban-Derivate

1955 ◽  
Vol 88 (12) ◽  
pp. 1952-1956 ◽  
Author(s):  
Wily Logemann ◽  
Luigi Almirante ◽  
Lorenzo Caprio ◽  
Alberto Meli
Keyword(s):  
Rauwolfia Alkaloid
Sign in / Sign up

Export Citation Format

Share Document