Effect of diltiazem on pacing-induced ischemia in conscious dogs with coronary stenosis: Improvement of postpacing deterioration of ischemic myocardial function

1981 ◽  
Vol 48 (3) ◽  
pp. 460-467 ◽  
Author(s):  
Shigetake Sasayama ◽  
Masaaki Takahashi ◽  
Masaharu Nakamura ◽  
Akira Ohyagi ◽  
Akiko Yamamoto ◽  
...  
Keyword(s):  
Coronary Stenosis ◽  
Myocardial Function ◽  
Conscious Dogs

Regional myocardial effects of intracoronary bradykinin in conscious dogs

1997 ◽  
Vol 272 (3) ◽  
pp. H1266-H1274 ◽  
Author(s):  
R. Houel ◽  
J. Su ◽  
F. Barbe ◽  
R. Choussat ◽  
B. Crozatier ◽  
...  
Keyword(s):  
Myocardial Function ◽  
Enzyme Inhibitor ◽  
Posterior Wall ◽  
Left Ventricular ◽  
Conscious Dogs ◽  
Wall Thickening ◽  
Regional Myocardial Function ◽  
Systemic Hemodynamic ◽  
Systolic Wall Thickening ◽  
Dose Dependent

This study examined in conscious dogs, the coronary and regional myocardial effects of bradykinin (BK) administered by intracoronary route and their modulation by an angiotensin-converting enzyme inhibitor. Eleven dogs were chronically instrumented with a left ventricular (LV) micromanometer, a circumflex coronary catheter, a flow probe, and ultrasonic crystals in the LV posterior wall. In the absence of systemic hemodynamic changes, BK (0.1-10 ng/kg i.c.) produced dose-dependent increases in coronary blood flow velocity (CBFV) and in LV posterior end-diastolic wall thickness (EDWT) but produced no change in LV regional myocardial function as assessed by LV posterior systolic wall thickening. The increases in LV EDWT and CBFV were linearly correlated. The BK B2 antagonist (HOE 140) abolished the effects of BK. Intracoronary enalaprilat (0.75 mg) extended the duration of the effect of BK on CBFV without modification of peak responses and induced a further increase in LV posterior EDWT but no change in LV regional myocardial function. Thus, in conscious dogs, the vasodilator effect of intracoronary BK alone or modulated by enalaprilat is not associated with changes in LV regional myocardial function.

Effect of coronary stenosis on myocardial function, ultrastructure and aortocoronary bypass graft hemodynamics

1978 ◽  
Vol 42 (2) ◽  
pp. 193-201 ◽  
Author(s):  
Franz Schwarz ◽  
Willem Flameng ◽  
Klaus-Ulrich Thiedemann ◽  
Wolfgang Schaper ◽  
Martin Schlepper
Keyword(s):  
Coronary Stenosis ◽  
Myocardial Function ◽  
Bypass Graft ◽  
Aortocoronary Bypass ◽  
Aortocoronary Bypass Graft

Coronary arterial reperfusion. III. Early and late effects on regional myocardial function and dimensions in conscious dogs

1976 ◽  
Vol 38 (5) ◽  
pp. 599-606 ◽  
Author(s):  
Pierre Theroux ◽  
John Ross ◽  
Dean Franklin ◽  
William S. Kemper ◽  
Shigetake Sasayama
Keyword(s):  
Late Effects ◽  
Myocardial Function ◽  
Conscious Dogs ◽  
Regional Myocardial Function

Subendocardial ischemia provoked by tachycardia in conscious dogs with coronary stenosis

1975 ◽  
Vol 35 (1) ◽  
pp. 30-36 ◽  
Author(s):  
William A. Neill ◽  
John Oxendine ◽  
Nancy Phelps ◽  
Richard P. Anderson
Keyword(s):  
Coronary Stenosis ◽  
Conscious Dogs ◽  
Subendocardial Ischemia

The effect of hemodilution on regional myocardial function in the presence of coronary stenosis

1977 ◽  
Vol 72 (4) ◽  
pp. 344-364 ◽  
Author(s):  
S. Hagl ◽  
W. Heimisch ◽  
H. Meisner ◽  
R. Erben ◽  
M. Baum ◽  
...  
Keyword(s):  
Coronary Stenosis ◽  
Myocardial Function ◽  
Regional Myocardial Function
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