The effect of interruption of collateral blood flow on conduction delay and arrhythmias during acute myocardial ischemia

1981 ◽  
Vol 47 ◽  
pp. 391
Author(s):  
David E. Euler ◽  
Charles E. Prood ◽  
E. Neil Moore ◽  
Joseph F. Spear
Keyword(s):  
Blood Flow ◽  
Myocardial Ischemia ◽  
Acute Myocardial Ischemia ◽  
Conduction Delay ◽  
Collateral Blood Flow

Transmural pH gradient in canine myocardial ischemia

1984 ◽  
Vol 246 (2) ◽  
pp. H232-H238 ◽  
Author(s):  
R. M. Watson ◽  
D. R. Markle ◽  
Y. M. Ro ◽  
S. R. Goldstein ◽  
D. A. McGuire ◽  
...  
Keyword(s):  
Blood Flow ◽  
Myocardial Ischemia ◽  
Coronary Stenosis ◽  
Fiber Optic ◽  
Acute Myocardial Ischemia ◽  
Ph Gradient ◽  
Ph Values ◽  
Probe System ◽  
Ph Probes ◽  
Transmural Gradient

The subendocardium is more susceptible to ischemia than the subepicardium. Studies during critical coronary stenosis have demonstrated subendocardial hypoperfusion relative to the subepicardium and transmural gradients in certain tissue metabolites. Although ischemia causes acidosis, the existence of a transmural pH gradient has never been demonstrated or quantitated. Thus we reduced coronary blood flow to 20 +/- 5% of normal in eight open chest anesthetized (morphine sulfate and pentobarbital) dogs and to 45 +/- 5% in two dogs. We implanted specially designed miniature fiber-optic pH probes in normal and ischemic subendocardium (depth 5.5-8 mm) and subepicardium (depth 3-4 mm). Separate experiments validated use of the fiber-optic pH probe system to measure tissue pH. Although both probes were located in the ischemic zone, there was a large transmural gradient, i.e., from normal pH values (7.36) in the subepicardium to severely acidotic (pH 6.94) 2 mm deeper in the subendocardium. This marked difference in pH between nearby transmural layers may have important implications regarding arrhythmogenesis in the setting of acute myocardial ischemia.

Neuromodulation therapy does not influence blood flow distribution or left-ventricular dynamics during acute myocardial ischemia

2001 ◽  
Vol 91 (1-2) ◽  
pp. 47-54 ◽  
Author(s):  
John G Kingma ◽  
Bengt Linderoth ◽  
Jeffrey L Ardell ◽  
John A Armour ◽  
Michael J.L DeJongste ◽  
...  
Keyword(s):  
Blood Flow ◽  
Myocardial Ischemia ◽  
Flow Distribution ◽  
Left Ventricular ◽  
Acute Myocardial Ischemia ◽  
Blood Flow Distribution ◽  
Ventricular Dynamics
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