Inhibition of rat liver glutathione S-transferases by glutathione conjugates and corresponding l-cysteines and mercapturic acids

1986 ◽  
Vol 35 (4) ◽  
pp. 651-654 ◽  
Author(s):  
Lay Khoon Ong ◽  
Alan G. Clark
Keyword(s):  
Rat Liver ◽  
Mercapturic Acids ◽  
Liver Glutathione ◽  
Glutathione Conjugates ◽  
Glutathione S Transferases

scholarly journals Studies on the subunit composition of rat liver glutathione S-transferases.

1983 ◽  
Vol 258 (18) ◽  
pp. 11321-11325 ◽  
Author(s):  
A B Frey ◽  
T Friedberg ◽  
F Oesch ◽  
G Kreibich
Keyword(s):  
Rat Liver ◽  
Subunit Composition ◽  
Liver Glutathione ◽  
Glutathione S Transferases

scholarly journals Epoxy derivatives of aromatic polycyclic hydrocarbons. The preparation of benz[a]anthracene 8,9-oxide and 10,11-dihydrobenz[a]anthracene 8,9-oxide and their metabolism by rat liver preparations

1971 ◽  
Vol 125 (1) ◽  
pp. 159-168 ◽  
Author(s):  
P. Sims
Keyword(s):  
Rat Liver ◽  
Reduced Glutathione ◽  
Mercapturic Acids ◽  
Polycyclic Hydrocarbons ◽  
Glutathione Conjugates ◽  
Liver Homogenates ◽  
Derivatives Of ◽  
Related Compounds

The syntheses of 10,11-dihydrobenz[a]anthracene 8,9-oxide, benz[a]anthracene 8,9-oxide and 9-hydroxybenz[a]anthracene are described, together with those of a number of related compounds. The epoxides react both chemically and enzymically with water to yield the corresponding dihydrodiols and with reduced glutathione to form glutathione conjugates, and they react chemically with N-acetylcysteine to yield the corresponding mercapturic acids. 8,9-Dihydro-8,9-dihydroxybenz[a]anthracene, formed enzymically from benz[a]anthracene 8,9-oxide, was identical with a dihydrodiol formed when benz[a]anthracene was metabolized by rat liver homogenates. Similarly 10,11-dihydrobenz[a]anthracene 8,9-oxide yielded a dihydrodiol identical with the product formed when 10,11-dihydrobenz[a]anthracene was metabolized.

Subunit composition of rat liver glutathione S-transferases

1982 ◽  
Vol 108 (2) ◽  
pp. 461-467 ◽  
Author(s):  
Chen-Pei D. Tu ◽  
Mitchell J. Weiss ◽  
C. Channa Reddy
Keyword(s):  
Rat Liver ◽  
Subunit Composition ◽  
Liver Glutathione ◽  
Glutathione S Transferases

Inhibition by sulfasalazine of LTC synthetase and of rat liver glutathione S-transferases

1985 ◽  
Vol 34 (15) ◽  
pp. 2695-2704 ◽  
Author(s):  
Michael K. Bach ◽  
John R. Brashler ◽  
Mark A. Johnson
Keyword(s):  
Rat Liver ◽  
Liver Glutathione ◽  
Glutathione S Transferases
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