Pravastatin inhibited the cholesterol synthesis in human hepatoma cell line Hep G2 less than simvastatin and lovastatin, which is reflected in the upregulation of 3-hydroxy-3-methylglutaryl coenzyme a reductase and squalene synthase

1993 ◽  
Vol 45 (11) ◽  
pp. 2203-2208 ◽  
Author(s):  
Louis H. Cohen ◽  
Arlène Van Vliet ◽  
Loes Roodenburg ◽  
Lucres M.C. Jansen ◽  
Marieke Griffigen
Keyword(s):  
Cell Line ◽  
Cholesterol Synthesis ◽  
Coenzyme A ◽  
Hepatoma Cell ◽  
Squalene Synthase ◽  
Hepatoma Cell Line ◽  
Human Hepatoma ◽  
Hep G2 ◽  
Human Hepatoma Cell ◽  
Human Hepatoma Cell Line

Cyclic AMP decseases LDL catabolism and cholesterol synthesis in the human hepatoma cell line HepG2

1988 ◽  
Vol 156 (1) ◽  
pp. 424-431 ◽  
Author(s):  
Cécile Maziere ◽  
Jean-Claude Maziere ◽  
Suzanne Salmon ◽  
Martine Auclair ◽  
Liliana Mora ◽  
...  
Keyword(s):  
Cyclic Amp ◽  
Cell Line ◽  
Cholesterol Synthesis ◽  
Hepatoma Cell ◽  
Hepatoma Cell Line ◽  
Human Hepatoma ◽  
Human Hepatoma Cell ◽  
Human Hepatoma Cell Line ◽  
Hepatoma Cell Line Hepg2 ◽  
Ldl Catabolism

Metabolism of a novel antitumor agent, crisnatol, by a human hepatoma cell line, Hep G2, and hepatic microsomes

1991 ◽  
Vol 42 (2) ◽  
pp. 337-346 ◽  
Author(s):  
Dipak K. Patel ◽  
John P. Shockcor ◽  
Sai Y. Chang ◽  
Carl W. Sigel ◽  
Brian E. Huber
Keyword(s):  
Cell Line ◽  
Hepatoma Cell ◽  
Antitumor Agent ◽  
Hepatoma Cell Line ◽  
Human Hepatoma ◽  
Hep G2 ◽  
Human Hepatoma Cell ◽  
Human Hepatoma Cell Line ◽  
Hepatic Microsomes

Human herpesvirus 6 induces IL-8 gene expression in human hepatoma cell line, Hep G2

1996 ◽  
Vol 49 (1) ◽  
pp. 34-40 ◽  
Author(s):  
Reiko Inagi ◽  
Ratigorn Guntapong ◽  
Masayuki Nakao ◽  
Yoshizumi Ishino ◽  
Kazunobu Kawanishi ◽  
...  
Keyword(s):  
Gene Expression ◽  
Cell Line ◽  
Hepatoma Cell ◽  
Human Herpesvirus ◽  
Hepatoma Cell Line ◽  
Human Hepatoma ◽  
Human Herpesvirus 6 ◽  
Hep G2 ◽  
Human Hepatoma Cell ◽  
Human Hepatoma Cell Line

Status of reduced glutathione in the human hepatoma cell line, HEP G2

1988 ◽  
Vol 37 (17) ◽  
pp. 3365-3368 ◽  
Author(s):  
Susan J. Duthie ◽  
Catherine S. Coleman ◽  
M.Helen Grant
Keyword(s):  
Cell Line ◽  
Reduced Glutathione ◽  
Hepatoma Cell ◽  
Hepatoma Cell Line ◽  
Human Hepatoma ◽  
Hep G2 ◽  
Human Hepatoma Cell ◽  
Human Hepatoma Cell Line

scholarly journals The metabolism in vitro of human low-density lipoprotein by the human hepatoma cell line Hep G2

1983 ◽  
Vol 214 (3) ◽  
pp. 951-958 ◽  
Author(s):  
L Havekes ◽  
V van Hinsbergh ◽  
H J Kempen ◽  
J Emeis
Keyword(s):  
Cell Line ◽  
Hepatoma Cell ◽  
Hepatoma Cell Line ◽  
Human Hepatoma ◽  
Hep G2 ◽  
Hep G2 Cells ◽  
Human Hepatoma Cell ◽  
Human Hepatoma Cell Line ◽  
High Affinity ◽  
G2 Cells

The human hepatoma cell line Hep G2 was studied with respect to metabolism of human low-density lipoprotein (LDL). The Hep G2 cells bind, take up and degrade human LDL with a high-affinity saturable and with a low-affinity non-saturable component. The high-affinity binding possesses a KD of 25 nM-LDL and a maximal amount of binding of about 70 ng of LDL-apoprotein/mg of cell protein. The high-affinity binding, uptake and degradation of LDL by Hep G2 cells is dependent on the extracellular Ca2+ concentration and is down-regulated by the presence of fairly high concentrations of extracellular LDL. Incubation of the Hep G2 cells with LDL results in suppression of the intracellular cholesterol synthesis. It is concluded that the human hepatoma cell line Hep G2 possesses specific LDL receptors similar to the LDL receptors demonstrated on extrahepatic tissue cells.

Pulse-chase studies of the synthesis of apolipoprotein B in a human hepatoma cell line, Hep G2

1985 ◽  
Vol 149 (3) ◽  
pp. 461-466 ◽  
Author(s):  
Margit WETTESTEN ◽  
Kristina BOSTROM ◽  
Goran BONDJERS ◽  
Marianne JARFELDT ◽  
Per-Ingvar NORFELDT ◽  
...  
Keyword(s):  
Cell Line ◽  
Apolipoprotein B ◽  
Hepatoma Cell ◽  
Hepatoma Cell Line ◽  
Human Hepatoma ◽  
Hep G2 ◽  
Human Hepatoma Cell ◽  
Human Hepatoma Cell Line

The glycosphingolipid composition of the human hepatoma cell line, Hep-G2

1989 ◽  
Vol 273 (2) ◽  
pp. 578-591 ◽  
Author(s):  
P.F. Spitalnik ◽  
J.M. Danley ◽  
S.R. Burger ◽  
S.L. Spitalnik
Keyword(s):  
Cell Line ◽  
Hepatoma Cell ◽  
Hepatoma Cell Line ◽  
Human Hepatoma ◽  
Hep G2 ◽  
Human Hepatoma Cell ◽  
Human Hepatoma Cell Line
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