Abnormal involuntary movements and chronic schizophrenic disorders

A battery of tests for dyspraxia and agnosia was administered to 51 chronic schizophrenic patients to test the hypothesis that these cortical neurological signs are associated with psychomotor poverty syndrome (poverty of speech, flat affect, decreased spontaneous movement), disorganization syndrome (various disorders of the form of thought, inappropriate affect), abnormal involuntary movements, cognitive impairment, and duration of illness. The findings supported all elements of the hypothesis, and in particular, demonstrated a strong correlation of cortical signs with psychomotor poverty and with cognitive impairment.

Download Full-text

Striatal ΔFosB gene suppression inhibits the development of abnormal involuntary movements induced by L-Dopa in rats

Gene Therapy ◽

10.1038/s41434-021-00249-7 ◽

2021 ◽

Author(s):

Goichi Beck ◽

Jie Zhang ◽

Kayoko Fong ◽

Hideki Mochizuki ◽

M. Maral Mouradian ◽

...

Keyword(s):

Gene Suppression ◽

Abnormal Involuntary Movements ◽

Involuntary Movements

Download Full-text

The Nithsdale Schizophrenia Survey V. Follow-up of Tardive Dyskinesia at3-1/2 years

The British Journal of Psychiatry ◽

10.1192/bjp.149.5.621 ◽

1986 ◽

Vol 149 (5) ◽

pp. 621-623 ◽

Cited By ~ 12

Author(s):

A. D. T. Robinson ◽

R. G. McCreadie

Keyword(s):

Tardive Dyskinesia ◽

Older Patients ◽

Geographical Area ◽

Point Prevalence ◽

Abnormal Involuntary Movements ◽

Involuntary Movements ◽

Transient Feature

The point-prevalence of tardive dyskinesia in schizophrenics from a discrete geographical area (Nithsdale, in Dumfries and Galloway Region) in 1981, 1982, and 1984 was 31%, 27%, and 30% respectively. This suggests that the prevalence of tardive dyskinesia in a community of schizophrenics has reached a plateau. In 12% of patients there was persistent dyskinesia, i.e. abnormal involuntary movements were present at all three assessments. Persistent dyskinesia was more common in older patients. The severity of tardive dyskinesia fluctuated between assessments in 41 % of patients, indicating that it is only a transient feature in some cases.

Download Full-text

Tardive Dyskinesia

The British Journal of Psychiatry ◽

10.1192/bjp.160.1.110 ◽

1992 ◽

Vol 160 (1) ◽

pp. 110-112 ◽

Cited By ~ 15

Author(s):

Robertson Macpherson ◽

Rachel Collis

Keyword(s):

Cognitive Function ◽

Tardive Dyskinesia ◽

Psychiatric Hospital ◽

Negative Symptoms ◽

Cognitive Deficit ◽

Defect State ◽

Abnormal Involuntary Movements ◽

Involuntary Movements ◽

Short Test

Of 113 patients in long-stay wards of a psychiatric hospital, 43 had TD. Twenty-six of the 39 patients who consented to take part in the study were unaware of abnormal involuntary movements. These patients scored significantly lower on a short test of cognitive function than patients who were aware of such movements. The diagnosis of schizophrenia, perticularly the ‘defect’ state with cognitive deficit and negative symptoms, was found to be associated with lack of awareness of TD.

Download Full-text