Recovery of anosmia in hamsters infected with SARS-CoV-2 is correlated with repair of the olfactory epithelium

Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is responsible for a pandemic affecting billions of people worldwide. Apart from the extreme global economic impact, the pandemic will likely have a lasting impact through long-term sequelae not yet fully understood. Fully understanding the mechanisms driving the various symptoms and sequelae of SARS-CoV-2 infection will allow for the eventual development of therapeutics to prevent or treat such life-altering symptoms. In this study, we developed a behavioral test of anosmia in SARS-CoV-2-infected hamsters. We find a moderately strong correlation between the level of anosmia and the score of histological damage within the olfactory epithelium. We also find a moderately strong correlation between the level of anosmia and the thickness of the olfactory epithelium, previously demonstrated to be severely damaged upon infection. Thus, this food-searching behavioral test can act as a simple and effective screening method in a hamster model for various therapeutics for SARS-CoV-2-related anosmia.

Diversity of and Differentiation for Gifted English Learners

This chapter presents a need to understand the diversity of the English learner population. Within this large multi-lingual group of students, there is a richness of diversity in languages, skills, histories, abilities, and experiences. Teaching for differences begins by learning about the students in the classroom. English learners collectively share language needs, but as individuals require attention to their own personal assets and abilities and ongoing learning needs. This chapter presents suggestions for teaching English learners through the lens of differentiation and extends to individualization and personalization. Strategies for supporting the unique needs within and across the multi-lingual learning population are presented. A focus on maximizing thinking shows a strong correlation to language development. Therefore, this chapter presents instruction for English learners as rigorous and challenging to promote thinking and language development.

Uji Spesifikasi Pengukuran PM10 Dengan EPAM5000 dan BAM 1020 Terhadap Kelembaban Udara

PM10 merupakan salah satu aerosol yang merupakan bagian dari partikel pencemar. Keberadaannya menempati volume ruang di atmosfer dengan konsentrasi yang selalu tergabung dengan materi lainnya dan dipengaruhi oleh kondisi atmosfer setempat. Pengukuran PM10 pada periode waktu siang dan malam dengan menggunakan EPAM5000 dan BAM1020 telah dilakukan untuk mengetahui specifikasi alat terhadap hasil pengukuran pada responnya terhadap unsur cuaca (kelembaban). Data hasil pengukuran dan analisis korelasi menunjukkan bahwa terdapat perbedaan pada hasil ukur konsentrasi PM10 pada periode malam pada EPAM5000 dan BAM1020 yang disebabkan oleh perbedaan pendukung instrument pada aliran udara masuk. Adanya smart heather pada BAM1020 berfungsi untuk mengontrol kadar uap air dari aliran udara yang dihisap sedangan pada EPAM5000 udara yang dihisap langsung diukur kosentrasinya sehingga hasil ukur konsentrasi PM10 pada EPAM5000 lebih tinggi karena masih mengandung banyak uap air (aerosol hidroskopis). Adanya menu Manual Zero atau Auto Zero pada EPAM5000 untuk membersihkan optic sensor dan mereset menjadi 0 mg/m3. Pada periode malam, partikulat PM10 akan bergabung dengan uap air menyebabkan konsentrsi yang terukur pada EPAM5000 tinggi. Hal ini diperkuat oleh hasil korelasi menunjukkan bahwa nilai PM10 berkorelasi kuat terhadap kelembaban data pengukuran EPAM5000. Untuk ini perlu adanya metode untuk memisahkan PM10 dan materi lainnya (uap air) agar didapatkan nilai konsentarsi yang sebenarnya untuk menentukan kebijakan terkait kondisi udara yang terjadi.ABSTRACTPM10 is one of the aerosols which is part of polluting particles. Its existence occupies a volume of space in the atmosphere with a concentration that is always combined with other materials and is influenced by local atmospheric conditions. Measurement of PM10 in the time period of day and night using EPAM5000 and BAM1020 has been carried out to determine the specifications of the instrument on the measurement results in response to weather elements (humidity). Measurement data and correlation analysis indicate that there are differences in the results of measuring PM10 concentrations in the night period on EPAM5000 and BAM1020 due to differences in instrument support in the intake air flow. The presence of a smart heather on the BAM1020 functions to control the water vapor content of the sucked air stream, while on the EPAM5000 the air that is sucked is directly measured so that the concentration of PM10 on EPAM5000 is higher because it still contains a lot of water vapor (hydroscopic aerosol). There is a Manual Zero or Auto Zero menu on the EPAM5000 to clean the optical sensor and reset it to 0 mg/m3. During the night period, PM10 particulates will combine with water vapor causing concentrations measured at high EPAM5000. This is confirmed by the correlation results showing that the PM10 value has a strong correlation to the humidity of the EPAM5000 measurement data. For this, it is necessary to have a method for separating PM10 and other materials (water vapor) in order to obtain the actual concentration value to determine policies related to air conditions that occur.

The Modeling of the Capacity of the Moroccan Healthcare System in the Context of COVID-19

The outbreak of SARS-Cov2 in China and its subsequent spread has caused a global pandemic. The authors conducted a simple susceptible-infected (SI) model of the spread of COVID-19 in Moroccan population. The model is based on combining the average contact rate (µmax) extracted from the early exponential phase of the outbreak with a logistic simulation over time. Interestingly, this modeling approach showed a perfect fit with a strong correlation between real confirmed and estimated cases when calibrated on the Chinese declining outbreak. Subsequently, the model was applied for studying the ongoing COVID-19 outbreak in Morocco to determine the needed time for reaching 10,000 confirmed cases whose 15% (1,500) are at risk of developing health complications requiring patient care in hospitals. The latter total capacity does not exceed 1,640 beds according to the authorities. Incorporating these parameters in the logistic model, they predicted that the Moroccan healthcare system will be at 27%, 50%, 76%, and 90% of saturation on April 11, 16, 23, and May 4, 2020, respectively.

Measurement properties of New Mobility Score to evaluate functional recovery in the elderly following total hip arthroplasty

Introduction/Objective. The aim of this study is to identify and evaluate the use of New Mobility Score in estimating functional recovery 3 months after total hip arthroplasty (THA). Methods. Seventy patients, aged > 60, who underwent THA. Treatment group was subjected to the comprehensive rehabilitation program and control group to the standard one. Primary outcome was assessed with Harris Hip Score (HHS) and New Mobility Score (NMS), and secondary one by Medical Outcomes Health Survey (Short Form Health Survey - SF-36). Questionnaires were collected before and three months after hip surgery. Results. Treatment group showed significant improvement 3 months postoperatively. The correlation in both groups between HHS and NMS was very strong (r > 0.700). Treatment group following surgery showed strong correlation between Recovery through Personal Care Services (PCS) and HHS and NMS (r > 0.700), moderate to strong between pain categories and HHS (r = 0.380; r = 0.583) and NMS (r = 0.424). Control group showed strong correlation between PCS and HHS (r = 0.704), and NMS (r = 0.568) and moderate to pain categories and HHS (r = 0.546; r = 0.466). The area under the curve (AUC) described the inherent validity of all measurement used AUCNMS = 0.724, p = 0.001, AUCHHS = 0.788, p = 0.000 and AUCPCS = 0.747, p = 0.001. Conclusion. The NMS could be successfully used in routine clinical assessment of elderly patients following THA. The trial is registered in ISRCTN Register with https://doi.org/10.1186/ISRCTN73197506

Simulation and analysis of partial pulse remained jamming to HPRF PD radar

To solve the problem that the duty cycle of HPRF PD radar is not easy to use the general tow-and-pull jamming, a method of partial pulse remained jamming is proposed. Taking the transmitting signal of PD radar acquired by DRFM as an example, the jamming effect of the signal is simulated and analyzed. The results show that the jamming signal is modulated by the radar signal acquired by DRFM, the jamming signal generated has a strong correlation with the target Echo Signal, and it can effectively jam the HPRF PD radar with less power, which proves the effectiveness of the method.

Does Innovation, Investment and Trade influence Labour Productivity? Empirical Evidence from Selected Countries

Labour productivity is linked to improved living standards of a country, where higher productivity is usually seen as a competitive advantage for the country. The current study aims to identify the influence of investment, trade, and innovation on labour productivity using multi-regression. The sample involved four countries: the United States, Russia, Japan, and China. The results reveal varying degrees of relationships between labour productivity and other variables. In general, investment showed a strong correlation, trade showed a weaker relationship, and innovation showed insignificant relationship. When needed, the policymakers may consider raising labour productivity by improving investment or trade.

Investigating the causal relationship between economic growth, inflation, and unemployment in South Korea

Policymakers and economists consistently implement monetary and fiscal policy to control economic growth, inflation, and unemployment due to the fact that these three factors directly influence people’s living standards. Every country has a different economic characteristic structure. Economic growth and inflation have a strong correlation in some countries, while other countries have a strong correlation between economic growth and unemployment. Therefore, investigating the causal relationship among economic factors can provide us with a better understanding of how economic phenomena affect each other. In South Korea, economic growth, inflation, unemployment have been in balance since the 1998 Korean economic crisis. Hence, investigating the economic growth, inflation, and unemployment of South Korea will enlighten how these three economic indicators affect each other in a country that developed rapidly and had several economic crises. To investigate such a model, the Vector Autoregressive Model (VAR) is used with the data between the years 1980 and 2019 in order to verify whether Okun’s law or/and the Philips curve hold in South Korea. The research also determines if there is either a bi-directional or uni-directional relationship if economic growth, inflation, and unemployment have a causal relationship. The research demonstrates that GDP is the main factor in South Korea that influences the other economic factors. This research paper can contribute to academia, since it has a vital outcome which shows that the mobility of the unemployment rate in South Korea is directly correlated to the movement of GDP.

Road traffic noise assessment in a hospital area in Umuarama - Brazil

In hospital environments, high noise levels can result in damage to patients' treatments, delaying their rest and recovery. The sound pressure level (SPL) in hospital areas during the day must not exceed 50 dB and 45 dB (A) at night, according to NBR 10.151/2019. This research aimed to carry out environmental monitoring of equivalent sound pressure levels (LAeq) at fifteen points in the vicinity of three hospitals in the central region of the municipality of Umuarama-PR, during working days, at four different times, in the months of August, September and November 2018 and continued in March 2019. To this end, we sought to map the LAeq of the points, compare them with data from municipal and federal legislation and relate the LAeq to the volume of vehicular traffic. The collected SPL were higher than recommended by NBR 10.151 at all times and measurement points, during the week, and when considering the municipal regulations, only one point is in the equipment's accuracy limit. From the statistical analysis, a very strong correlation was observed between LAeq and the total volume of vehicles, and also a strong correlation between the descriptors L10 and L50 and the volume of vehicles. The Traffic Noise Index (TNI) was also calculated and the LAeq values ​​were compared with a subjective noise rating. The results show a scenario of noise pollution in the area and there is a need for the application of mitigating measures.