T75. METABOLIC SYNDROME AND HEAR RATE VARIABILITY IN SCHIZOPHRENIC INPATIENTS

Background The purpose of this study was to explore the relationships between metabolic syndrome and markers of heart rate variability (HRV) in chronic schizophrenic inpatients Methods A total of 99 schizophrenic inpatients was included in this study. Metabolic syndrome of patients was defined according to the revised NCEP-ATP III criteria. HRV was measured by SA-3000P (Medi-core, Seoul, Korea). Psychopathology, anxiety state of patients, psychosocial functional state and subjective well-being were examined by Positive and Negative Symptom Scale (PANSS), Hamilton Anxiety Inventory (HAM-A), Social and Occupational Functioning Assessment (SOFAS) and Satisfaction with Life Scale (SWLS), respectively. Comparisons of data were done between patients with metabolic syndrome and without metabolic syndrome. Results Fifty-four (54.5%) of 99 patients had satisfied the criteria of metabolic syndrome. Patients with metabolic syndrome showed significant higher negative symptoms scores in PANSS (p<0.05) and HAM-A scores (p<0.05) than patients without metabolic syndrome. Age, sex, smoking status, age at onset, duration of illness, scores of SOFAS and SWLS were not differed between two groups. Data of HRV were transformed to log values to satisfy the hypothesis of normal distribution of curve. SDNN of Time domain was significantly differed between two groups (p<0.05). Activation of autonomic nerve, resistance of stress, index of stress, rate of fatigue and heart stability were also significantly differed between groups (p<0.05, respectively). Multiple linear regression was done to explore which factors were associated with HRV and metabolic syndrome. Metabolic syndrome was negatively influenced to InTP, InVLF, InLF and InHF of HRV (frequency domain). Discussion This study suggested that metabolic syndrome was negatively influenced to the frequency domain of HRV in chronic schizophrenic patients.