Projection of tooth pulp afferents to the cat trigeminal nucleus caudalis

1975 ◽  
Vol 90 (2) ◽  
pp. 195-204 ◽  
Author(s):  
Samuel G. Nord ◽  
Ronald F. Young
Keyword(s):  
Tooth Pulp ◽  
Trigeminal Nucleus ◽  
Trigeminal Nucleus Caudalis

Serotonin inhibits release of substance P evoked by tooth pulp stimulation in trigeminal nucleus caudalis in rabbits

1991 ◽  
Vol 30 (1) ◽  
pp. 5-13 ◽  
Author(s):  
N. Yonehara ◽  
T. Shibutani ◽  
Y. Imai ◽  
Y. Ooi ◽  
T. Sawada ◽  
...  
Keyword(s):  
Substance P ◽  
Tooth Pulp ◽  
Trigeminal Nucleus ◽  
Trigeminal Nucleus Caudalis

Excitation and inhibition of neurons in the trigeminal nucleus caudalis following periaqueductal gray stimulation

1978 ◽  
Vol 56 (1) ◽  
pp. 157-161 ◽  
Author(s):  
R. K. Andersen ◽  
J. P. Lund ◽  
E. Puil
Keyword(s):  
Periaqueductal Gray ◽  
Infraorbital Nerve ◽  
Reflex Response ◽  
Tooth Pulp ◽  
Trigeminal Nucleus ◽  
Trigeminal Nucleus Caudalis ◽  
Jaw Opening ◽  
Narcotic Analgesia ◽  
Jaw Opening Reflex ◽  
Decerebrate Cats

Electrical stimulation (3–4 shocks, 300 Hz, 30–150 μA) of the periaqueductal gray matter (CG) or dorsal raphé nucleus (DR) of decerebrate cats reduced or abolished the jaw-opening reflex response evoked by stimulation of either the tooth pulp or infraorbital nerve. In addition, CG or DR stimulation inhibited the response of 12 out of 16 trigeminal nucleus caudalis neurons to activation of their sensory afferent inputs. Ten other neurons recorded in the same sites, and often at the same time, but which did not respond to the sensory inputs utilized, were excited by identical stimuli to CG or DR. This excitatory response was blocked by intravenously administered naloxone (0.1–0.2 mg/kg). It is suggested that those neurons which are excited by CG and DR stimulation may be interneurons involved in pre- and post-synaptic inhibition of sensory transmission during stimulus-produced or narcotic analgesia.

Enkephalin and substance P effects related to trigeminal pain

1978 ◽  
Vol 56 (2) ◽  
pp. 216-222 ◽  
Author(s):  
R. K. Andersen ◽  
J. P. Lund ◽  
E. Puil
Keyword(s):  
Substance P ◽  
Firing Frequency ◽  
Tooth Pulp ◽  
Trigeminal System ◽  
Noxious Stimulation ◽  
Spontaneous Firing ◽  
Trigeminal Nucleus ◽  
Nociceptive Neurons ◽  
Trigeminal Nucleus Caudalis ◽  
Temporal Aspects

Iontophoretic applications of enkephalin (20–150 nA) reduced the spontaneous firing frequency of nociceptive neurons in the trigeminal nucleus caudalis of decerebrated cats. The response evoked by noxious stimulation (tooth pulp) was gradually inhibited during the 1st minute of application of the opioid and generally remained depressed for 5 min after the current was turned off. These effects of enkephalin were blocked by intravenously or iontophoretically administered naloxone. Nonnociceptive neurons or nociceptive neurons responding to nonnoxious inputs were less frequently inhibited by enkephalin. When tested on nonnociceptive cells, similar applications of substance P usually had little effect. Nociceptive neurons, however, were strongly excited by substance P. This action was not constant and was interrupted by periods of inactivation. Both types of peptide action were similar in temporal aspects. The results suggest a functional interrelationship between enkephalin and substance P in a trigeminal system mediating nociception.

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