Trihalomethanes induce sister chromatid exchanges in human lymphocytes in vitro and mouse bone marrow cells in vivo

1983 ◽  
Vol 32 (1) ◽  
pp. 72-79 ◽  
Author(s):  
Kanehisa Morimoto ◽  
Akira Koizumi
Keyword(s):  
Bone Marrow ◽  
Sister Chromatid ◽  
Bone Marrow Cells ◽  
Human Lymphocytes ◽  
Sister Chromatid Exchanges ◽  
Mouse Bone Marrow ◽  
Chromatid Exchanges ◽  
Mouse Bone Marrow Cells

Sister chromatid exchanges produced by imipramine and desipramine in mouse bone marrow cells treated in vivo

2002 ◽  
Vol 132 (2) ◽  
pp. 123-129 ◽  
Author(s):  
R. Paniagua-Pérez ◽  
E. Madrigal-Bujaidar ◽  
C.S. Reyes ◽  
G.J. Pérez ◽  
M.O. Velasco ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Sister Chromatid ◽  
Bone Marrow Cells ◽  
Sister Chromatid Exchanges ◽  
Mouse Bone Marrow ◽  
Chromatid Exchanges ◽  
Mouse Bone Marrow Cells ◽  
Marrow Cells

Genotoxic Activity of the Aminophenols as Evidenced by the Induction of Sister Chromatid Exchanges

1982 ◽  
Vol 1 (4) ◽  
pp. 387-392 ◽  
Author(s):  
G. Kirchner ◽  
U. Bayer
Keyword(s):  
Sister Chromatid ◽  
Bone Marrow Cells ◽  
Human Lymphocytes ◽  
Chinese Hamster ◽  
Sister Chromatid Exchanges ◽  
Dependent Manner ◽  
Structural Isomers ◽  
Chromatid Exchanges

1 Most hair dyes contain the structural isomers ortho-, meta- and para-aminophenol which were investigated concerning their ability to induce sister chromatid exchanges (SCE) in cultured human lymphocytes in vitro and in Chinese hamster bone marrow cells in vivo. 2 In vitro only ortho-aminophenol significantly induced SCE in a dose-dependent manner. 3 In vivo none of the structural isomers increased significantly the SCE frequency. 4 It is concluded that ortho-aminophenol is a weak directly acting compound which is detoxified during its metabolism.

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