Liposomes containing 3H-actinomycin D. Differential tissue distribution by varying the mode of drug incorporation

1975 ◽  
Vol 11 (12) ◽  
pp. 883-889 ◽  
Author(s):  
Yueh-Erh Rahman ◽  
Walter E. Kisieleski ◽  
Evelyn M. Buess ◽  
Elizabeth A. Cerny
Author(s):  
Ronan Power ◽  
Kevin Cashman ◽  
Albert Flynn

Some reports have suggested differential tissue deposition of dietary trace minerals such as Zinc (Zn) when supplied to farm animals either chelated to amino acids or as inorganic salts. To test this hypothesis, an experiment was conducted to determine the ultimate tissue distribution of Zinc in rats fed either a radioactively-labeled 65Zn-chelate or 65ZnSO4. The 65Zn-chelate was prepared by heating a solution of 65ZnSO4 and an equimolar mixture of glycine and methionine for 5 minutes at 90°C. The resulting chelate was then separated from unincorporated 65ZnSO4 by gel filtration chromatography. Ten 25-d old male wistar rats (mean weight 34.5 g) were randomized by weight into two groups (n = 5/group), fasted for 18 hours and given 0.4 ml (8 μg Zn, 1 μCi65Zn) of one or other labelled solution by gavage. Four hours later, animals were returned to their normal diet for the duration of the experiment. The 65Zn activity of the animals was determined two hours after administration and daily thereafter for 7 days.


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...  

Author(s):  
U. Forsum ◽  
K. Claesson ◽  
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...  

1991 ◽  
Vol 96 (6) ◽  
pp. 531-538 ◽  
Author(s):  
W. J. Curry ◽  
C. F. Johnston ◽  
J. C. Hutton ◽  
S. D. Arden ◽  
N. G. Rutherford ◽  
...  

2012 ◽  
Vol 78 ◽  
pp. 89-97 ◽  
Author(s):  
Tri R. Nuringtyas ◽  
Young H. Choi ◽  
Robert Verpoorte ◽  
Peter G.L. Klinkhamer ◽  
Kirsten A. Leiss

2005 ◽  
Vol 323 (1) ◽  
pp. 147-155 ◽  
Author(s):  
Jens Nürnberger ◽  
Rosmaria Kavapurackal ◽  
Shi-Jun Zhang ◽  
Anabelle Opazo Saez ◽  
Gerd Heusch ◽  
...  

2004 ◽  
Vol 38 (12) ◽  
pp. 1329-1340 ◽  
Author(s):  
Manal Abd El Mohsen ◽  
Joanne Marks ◽  
Gunter Kuhnle ◽  
Catherine Rice-Evans ◽  
Kevin Moore ◽  
...  

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