Smooth muscle relaxation and inhibition of responses to pinacidil and cromakalim induced by phentolamine in guinea-pig isolated trachea

1992 ◽  
Vol 211 (2) ◽  
pp. 235-241 ◽  
Author(s):  
Lone Bang ◽  
Jens Erik Nielsen-Kudsk
Keyword(s):  
Smooth Muscle ◽  
Guinea Pig ◽  
Muscle Relaxation ◽  
Smooth Muscle Relaxation ◽  
Isolated Trachea

scholarly journals Effect of β,γ-methylene ATP on smooth muscle relaxation in guinea pig duodenum

1998 ◽  
Vol 76 ◽  
pp. 239
Author(s):  
Satoko Ohkubo ◽  
Isao Matsuoka ◽  
Junko Kimura ◽  
Hironori Nakanishi
Keyword(s):  
Smooth Muscle ◽  
Guinea Pig ◽  
Muscle Relaxation ◽  
Smooth Muscle Relaxation

scholarly journals Long lasting smooth muscle relaxation by a novel PACAP analogue in guinea-pig and primate airways in vitro

1997 ◽  
Vol 121 (8) ◽  
pp. 1730-1734 ◽  
Author(s):  
Shigemi Yoshihara ◽  
Anders Lindén ◽  
Kazuhisa Kashimoto ◽  
Yumiko Nagano ◽  
Tohju Ichimura ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Guinea Pig ◽  
Muscle Relaxation ◽  
Smooth Muscle Relaxation

S-nitrosoglutathione breakdown prevents airway smooth muscle relaxation in the guinea pig

2000 ◽  
Vol 279 (4) ◽  
pp. L716-L721 ◽  
Author(s):  
Kezhong Fang ◽  
Roger Johns ◽  
Timothy Macdonald ◽  
Michael Kinter ◽  
Benjamin Gaston
Keyword(s):  
Smooth Muscle ◽  
Guinea Pig ◽  
Airway Smooth Muscle ◽  
Muscle Tone ◽  
Muscle Relaxation ◽  
Tracheal Ring ◽  
Protein Fractions ◽  
Smooth Muscle Relaxation ◽  
Smooth Muscle Tone ◽  
Catabolic Activity

Airway levels of the endogenous bronchodilator S-nitrosoglutathione (GSNO) are low in children with near-fatal asthma. We hypothesized that GSNO could be broken down in the lung and that this catabolism could inhibit airway smooth muscle relaxation. In our experiments, GSNO was broken down by guinea pig lung homogenates, particularly after ovalbumin sensitization (OS). Two lung protein fractions had catabolic activity. One was NADPH dependent and was more active after OS. The other was NADPH independent and was partially inhibited by aurothioglucose. Guinea pig lung tissue protein fractions with GSNO catabolic activity inhibited GSNO-mediated guinea pig tracheal ring relaxation. The relaxant effect of GSNO was partially restored by aurothioglucose. These observations suggest that catabolism of GSNO in the guinea pig 1) is mediated by lung proteins, 2) is partially upregulated after OS, and 3) may contribute to increased airway smooth muscle tone. We speculate that enzymatic breakdown of GSNO in the lung could contribute to asthma pathophysiology by inhibiting the beneficial effects of GSNO, including its effect on airway smooth muscle tone.

A Novel PACAP 1-27 Analogue Causes Sustained Smooth Muscle Relaxation in Guinea-Pig Tracheaa

2006 ◽  
Vol 805 (1) ◽  
pp. 536-542 ◽  
Author(s):  
S. YOSHIHARA ◽  
A. LINDÉN ◽  
K. KASHIMOTO ◽  
Y. NAGANO ◽  
T. ICHIMURA ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Guinea Pig ◽  
Muscle Relaxation ◽  
Smooth Muscle Relaxation
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