Cholera toxin but not pertussis toxin inhibits angiotensin II-enhanced contractions in the rat portal vein

1993 ◽  
Vol 230 (1) ◽  
pp. 95-97 ◽  
Author(s):  
Jisi Zhang ◽  
Jacques C.A. Van Meel ◽  
Martin Pfaffendorf ◽  
Pieter A. Van Zwieten
Keyword(s):  
Angiotensin Ii ◽  
Portal Vein ◽  
Cholera Toxin ◽  
Pertussis Toxin ◽  
Rat Portal Vein

Effect of a 14-day hindlimb suspension on cytosolic Ca2+ concentration in rat portal vein myocytes

1997 ◽  
Vol 273 (6) ◽  
pp. H2867-H2875 ◽  
Author(s):  
Jean-Luc Morel ◽  
François-Xavier Boittin ◽  
Guillaume Halet ◽  
Serge Arnaudeau ◽  
Chantal Mironneau ◽  
...  
Keyword(s):  
Angiotensin Ii ◽  
Sarcoplasmic Reticulum ◽  
Portal Vein ◽  
Complete Recovery ◽  
Hindlimb Suspension ◽  
Patch Clamp Technique ◽  
Voltage Gated ◽  
Rat Portal Vein ◽  
Inositol 1,4,5 Trisphosphate

Effects of a 14-day hindlimb suspension were examined on increases in cytosolic Ca2+ concentration ([Ca2+]i) evoked by vasoactive compounds and on Ca2+ channels in rat portal vein myocytes. The maximal increases in [Ca2+]ielicited by caffeine, norepinephrine, and angiotensin II were reduced by 30–50% in suspended rats, and complete recovery was obtained 4 days after suspension removal. In contrast, voltage-gated Ca2+ channels were unaffected by hindlimb suspension. Using both confocal microscopy and the patch-clamp technique, we measured local increases in [Ca2+]iwhich corresponded to activation of a small number of ryanodine-sensitive Ca2+-release channels (Ca2+ sparks) andd- myo-inositol 1,4,5-trisphosphate [Ins(1,4,5)P3]-gated Ca2+ channels. After hindlimb suspension, these local Ca2+events, as well as the Ca2+sensitivity of ryanodine-sensitive Ca2+ release channels, remained unchanged. In contrast, the propagated Ca2+ responses (Ca2+ waves) were significantly reduced in parallel with a noticeable inhibition of [3H]ryanodine binding to vascular membranes. Taken together, these results suggest that inhibition of the vasoconstrictor-induced increases in [Ca2+]iduring long-term suspension may be related to a reduction of the number of functional ryanodine-sensitive and Ins(1,4,5)P3-gated channels in the sarcoplasmic reticulum of rat portal vein myocytes.

scholarly journals Interactions between apelin and angiotensin II on rat portal vein

2006 ◽  
Vol 7 (4) ◽  
pp. 212-216 ◽  
Author(s):  
Bogdan Gurzu ◽  
Bogdan Cristian Petrescu ◽  
Marcel Costuleanu ◽  
Gheorghe Petrescu
Keyword(s):  
Angiotensin Ii ◽  
Portal Vein ◽  
Rat Portal Vein

Endothelium dependent expression and underlying mechanisms of des-Arg9-bradykinin-induced B1R-mediated vasoconstriction in rat portal vein

Peptides ◽  
2012 ◽  
Vol 37 (2) ◽  
pp. 216-224 ◽  
Author(s):  
Fernanda L. Basei ◽  
Daniela A. Cabrini ◽  
Cláudia P. Figueiredo ◽  
Stefânia Forner ◽  
Daniela B. Hara ◽  
...  
Keyword(s):  
Portal Vein ◽  
Rat Portal Vein ◽  
Underlying Mechanisms
Sign in / Sign up

Export Citation Format

Share Document