Lipoprotein fractions, lipoprotein lipase and hepatic triglyceride lipase during short-term and long-term uptake of ethanol in healthy subjects

1985 ◽  
Vol 57 (2-3) ◽  
pp. 281-291 ◽  
Author(s):  
J. Schneider ◽  
A. Liesenfeld ◽  
R. Mordasini ◽  
R. Schubotz ◽  
P. Zöfel ◽  
...  
Author(s):  
D. Blache ◽  
D. Bouthillier ◽  
A. Barbeau ◽  
J. Davignon

SUMMARY:Plasma triglycerides although within the normal range have been shown to be higher in Friedreich’s ataxia than in control subjects. To determine whether this difference could be ascribed to a reduced catabolism of triglyceride-rich lipoproteins, the activities of lipoprotein lipase (LPL) and hepatic triglyceride lipase (HL), released into plasma after an heparin injection, were measured in 13 cases of Friedreich’s ataxia and 14 control subjects of comparable signs. LPL was found to be significantly lower in the ataxic patients. Moreover about half of the cases clustered below the normal range for both lipase activities. This subgroup of Friedreich’s patients had significantly higher plasma triglycerides than those with normal lipase activities. Further studies are needed to relate these findings to other characteristics of the disease.


1985 ◽  
Vol 110 (4) ◽  
pp. 456-460 ◽  
Author(s):  
Shun Ishibashi ◽  
Toshio Murase ◽  
Nobuhiro Yamada ◽  
Kunimi Tanaka ◽  
Fumimaro Takaku ◽  
...  

Abstract. Five patients with hypopituitarism due to Sheehan's syndrome showed hyperlipidaemia of various lipoprotein phenotypes. Postheparin plasma lipoprotein lipase activity was subnormal in 4 of the 5 patients and hepatic triglyceride lipase was markedly decreased in all patients studied. After supplementation of both corticosteroid and thyroid hormones, lipoprotein lipase activity was restored to normal within 2 months, while it took longer for hepatic triglyceride lipase to return to normal. Together with the normalization of the two lipase activities, hyperlipidaemia subsided. The findings suggest that reduced activities of the two lipases may, at least in part, account for the development of hyperlipidaemia in hypopituitarism. The study identifies a new group of patients with hyperlipidaemia secondary to a disorder in endocrine function.


2015 ◽  
Vol 440 ◽  
pp. 193-200 ◽  
Author(s):  
Takashi Shirakawa ◽  
Katsuyuki Nakajima ◽  
Younosuke Shimomura ◽  
Junji Kobayashi ◽  
Kimber Stanhope ◽  
...  

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