Hyperlipidaemia in patients with hypopituitarism

1985 ◽  
Vol 110 (4) ◽  
pp. 456-460 ◽  
Author(s):  
Shun Ishibashi ◽  
Toshio Murase ◽  
Nobuhiro Yamada ◽  
Kunimi Tanaka ◽  
Fumimaro Takaku ◽  
...  
Keyword(s):  
Thyroid Hormones ◽  
Lipoprotein Lipase ◽  
Lipase Activity ◽  
Plasma Lipoprotein ◽  
Endocrine Function ◽  
Lipoprotein Lipase Activity ◽  
Hepatic Triglyceride ◽  
Triglyceride Lipase ◽  
Sheehan's Syndrome ◽  
Hepatic Triglyceride Lipase

Abstract. Five patients with hypopituitarism due to Sheehan's syndrome showed hyperlipidaemia of various lipoprotein phenotypes. Postheparin plasma lipoprotein lipase activity was subnormal in 4 of the 5 patients and hepatic triglyceride lipase was markedly decreased in all patients studied. After supplementation of both corticosteroid and thyroid hormones, lipoprotein lipase activity was restored to normal within 2 months, while it took longer for hepatic triglyceride lipase to return to normal. Together with the normalization of the two lipase activities, hyperlipidaemia subsided. The findings suggest that reduced activities of the two lipases may, at least in part, account for the development of hyperlipidaemia in hypopituitarism. The study identifies a new group of patients with hyperlipidaemia secondary to a disorder in endocrine function.

Kinetics Of Anticoagulant And Lipolytic Activity And Radiolabel After Intravenous Administration Of 35S-Heparin Fractions Of Different Molecular Weight

1981 ◽  
Author(s):  
C A M de Swart ◽  
J J Sixma ◽  
A Nijmeijer ◽  
E Holmer ◽  
L O Andersson ◽  
...  
Keyword(s):  
Lipoprotein Lipase ◽  
Lipase Activity ◽  
Antithrombin Iii ◽  
Lipolytic Activity ◽  
Convex Curve ◽  
Lipoprotein Lipase Activity ◽  
Hepatic Triglyceride ◽  
Triglyceride Lipase ◽  
Heparin Fractions ◽  
Hepatic Triglyceride Lipase

Heparin fractions were prepared from commercial pig mucosal by affinity chromatography on antithrombin III, 35S- radiolabelling and gelchromatography. Three fractions were obtained with moLwt.of < 6.000, 6 - 35.000 and > 35.000 daltons. They were administered intravenous as a bolus into human volunteers. The anticoagulant activity was measured with the APTT and Xa inactivation, using standard curves. The lipolytic activity was as^ed as hepatic triglyceride lipase activity, and as extra-hepatic lipoprotein lipase activity by hydrolysis of tritiated triolein. Radioactivity data were corrected for degraded heparin fragments uncomplexed to protein by subtracting radiolabel with a mol.wt. < 10.000 passing through a filter.Low mol.wt. fractions induced neither of both lipase activity and had no effect on the APTT. Anti Xa activity and radioactivity disappeared in parallel with slightly concave curves in semilogarthmic plots. Heparin of intermediate and high mol.wt. induced both lipolytic and both anticoagulant activities. The elimination of radioactivity, hepatic triglyceride lipase activity and anti-Xa activity occurred parallel according to a convex curve in semilogarthmic plots. The extra-hepatic lipoprotein lipase activity disappeared following a slightly concave curve.These data indicate that relatively large heparin molecules are required for lipolytic and APTT activity. Hepatic triglyceride lipase activity might be present complexed to heparin, comparable to the antithrombin III-heparin complex. The elimination of anti Xa activity and hepatic triglyceride lipase activity might be determined by the heparin part of the complexes.

Effects of probucol on plasma lipoprotein subfractions and activities of lipoprotein lipase and hepatic triglyceride lipase

1991 ◽  
Vol 88 (2-3) ◽  
pp. 175-181 ◽  
Author(s):  
Yasuhiko Homma ◽  
Emilio H. Moriguchi ◽  
Hiroya Sakane ◽  
Hideki Ozawa ◽  
Haruo Nakamura ◽  
...  
Keyword(s):  
Lipoprotein Lipase ◽  
Plasma Lipoprotein ◽  
Hepatic Triglyceride ◽  
Lipoprotein Subfractions ◽  
Triglyceride Lipase ◽  
Hepatic Triglyceride Lipase

SALT-RESISTANT TRIGLYCERIDE LIPASE RELATED TO POSTPARTUM DISEASE

1984 ◽  
Vol 64 (5) ◽  
pp. 248-249 ◽  
Author(s):  
J. LIESMAN ◽  
R. S. EMERY ◽  
B. GERLOFF ◽  
T. HERDT
Keyword(s):  
Fatty Liver ◽  
Key Words ◽  
Lipoprotein Lipase ◽  
Lipase Activity ◽  
Serum Lipids ◽  
Liver Fat ◽  
Hepatic Triglyceride ◽  
Triglyceride Lipase ◽  
Hepatic Triglyceride Lipase

Salt-resistant postheparin plasma lipase in recently parturient cows increased with increasing serum lipids and faster recovery from surgery. This lipase activity was decreased by fasting and excess liver fat. It seemed predominantly extrahepatic although a lipase with characteristics similar to hepatic triglyceride lipase was detected. Key words: Postheparin lipase, lipoprotein lipase, fatty liver, serum lipids

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