Benzpyrene hydroxylase activity in hepatic microsomal and solubilized systems containing rabbit or rat cytochrome P-448 or P-450

Life Sciences ◽  
1975 ◽  
Vol 16 (6) ◽  
pp. 985-997 ◽  
Author(s):  
Richard M. Philpot ◽  
John R. Bend
Keyword(s):  
Hydroxylase Activity ◽  
Benzpyrene Hydroxylase

Induction of Increased Benzpyrene Hydroxylase Activity in Pulmonary Tissue in Vitro

1968 ◽  
Vol 127 (2) ◽  
pp. 467-469 ◽  
Author(s):  
L. W. Wattenberg ◽  
J. L. Leong ◽  
A. R. Galbraith
Keyword(s):  
Hydroxylase Activity ◽  
Pulmonary Tissue ◽  
Benzpyrene Hydroxylase

scholarly journals BENZPYRENE HYDROXYLASE ACTIVITY IN ISOLATED PARENCHYMAL AND NONPARENCHYMAL CELLS OF RAT LIVER

1972 ◽  
Vol 52 (2) ◽  
pp. 316-321 ◽  
Author(s):  
Elroy Cantrell ◽  
Edward Bresnick
Keyword(s):  
Enzyme Activity ◽  
Rat Liver ◽  
Steroid Metabolism ◽  
Hydroxylase Activity ◽  
Adult Rats ◽  
Polycyclic Hydrocarbons ◽  
Nonparenchymal Cells ◽  
Parenchymal Cells ◽  
Benzpyrene Hydroxylase

Previous studies have implicated the reticuloendothelial cells of the liver in certain aspects of steroid metabolism. The similarity in the metabolism of steroids and polycyclic hydrocarbons suggested that the nonparenchymal cells possibly play a role in these areas. The present study presents evidence that at least one of the microsomal NADPH-requirig enzymes, benzpyrene hydroxylase, is present in nonparenchymal cells and, furthermore, is "inducible." In adult rats treated with 3-methylcholanthrene or ß-naphthoflavone, the nonparenchymal cells exhibited increases in benzpyrene hydroxylase activity of 17-fold and five-fold, respectively. Treatment with phenobarbital resulted in only a slight increase in enzyme activity. Enzyme activity in parenchymal cells under similar conditions was increased sixfold and fivefold by 3-methylcholanthrene and ß-naphthoflavone, respectively, but not by phenobarbital.

Hepatic benzpyrene hydroxylase activity in endrin susceptible and resistant pine mice

Life Sciences ◽  
1972 ◽  
Vol 11 (9) ◽  
pp. 477-483 ◽  
Author(s):  
Ryland E. Webb ◽  
Warren C. Randolph ◽  
Frank Horsfall
Keyword(s):  
Hydroxylase Activity ◽  
Benzpyrene Hydroxylase
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