The effects of ethanol ingestion on cyclic AMP, homovanillic acid and 5-hydroxyindoleacetic acid in human cerebrospinal fluid

Life Sciences ◽  
1976 ◽  
Vol 19 (11) ◽  
pp. 1669-1672 ◽  
Author(s):  
Elaine K. Orenberg ◽  
Vincent P. Zarcone ◽  
Jean F. Renson ◽  
Jack D. Barchas
Keyword(s):  
Cerebrospinal Fluid ◽  
Cyclic Amp ◽  
Homovanillic Acid ◽  
Ethanol Ingestion ◽  
Human Cerebrospinal Fluid ◽  
Hydroxyindoleacetic Acid

Noradrenergic Overactivity in Chronic Schizophrenia: Evidence Based on Cerebrospinal Fluid Noradrenaline and Cyclic Nucleotide Concentrations

1980 ◽  
Vol 137 (4) ◽  
pp. 346-351 ◽  
Author(s):  
U. C. R. Gomes ◽  
B. C. Shanley ◽  
L. Potgieter ◽  
J. T. Roux
Keyword(s):  
Cerebrospinal Fluid ◽  
Cyclic Nucleotides ◽  
Homovanillic Acid ◽  
Cyclic Adenosine Monophosphate ◽  
Adenosine Monophosphate ◽  
Chronic Schizophrenia ◽  
Evidence Based ◽  
Chronic Schizophrenics ◽  
Hydroxyindoleacetic Acid ◽  
Lumbar Cerebrospinal Fluid

SummaryConcentrations of noradrenaline (NA), homovanillic acid, 5-hydroxyindoleacetic acid and cyclic nucleotides were determined in lumbar cerebrospinal fluid (CSF) from acute and chronic schizophrenics and various groups of psychiatric and non-psychiatric control subjects. Statistically significant increases in NA and cyclic adenosine monophosphate were found in CSF from chronic schizophrenics compared to all other groups. These results were shown by statistical analyses to be unrelated to medication. They may be interpreted as evidence for noradrenergic overactivity as a possible primary abnormality in chronic schizophrenia.

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