Spontaneous sister-chromatid exchanges in Chinese hamster cells in vivo and in vitro

1981 ◽  
Vol 82 (2) ◽  
pp. 331-341 ◽  
Author(s):  
Shizuyo Sutou
Keyword(s):  
Sister Chromatid ◽  
Chinese Hamster ◽  
Sister Chromatid Exchanges ◽  
Chinese Hamster Cells ◽  
Chromatid Exchanges

Genotoxic Activity of the Aminophenols as Evidenced by the Induction of Sister Chromatid Exchanges

1982 ◽  
Vol 1 (4) ◽  
pp. 387-392 ◽  
Author(s):  
G. Kirchner ◽  
U. Bayer
Keyword(s):  
Sister Chromatid ◽  
Bone Marrow Cells ◽  
Human Lymphocytes ◽  
Chinese Hamster ◽  
Sister Chromatid Exchanges ◽  
Dependent Manner ◽  
Structural Isomers ◽  
Chromatid Exchanges

1 Most hair dyes contain the structural isomers ortho-, meta- and para-aminophenol which were investigated concerning their ability to induce sister chromatid exchanges (SCE) in cultured human lymphocytes in vitro and in Chinese hamster bone marrow cells in vivo. 2 In vitro only ortho-aminophenol significantly induced SCE in a dose-dependent manner. 3 In vivo none of the structural isomers increased significantly the SCE frequency. 4 It is concluded that ortho-aminophenol is a weak directly acting compound which is detoxified during its metabolism.

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