Induction of dominant lethal mutations by combines X-ray-acrylamide treatment in male mice

1990 ◽  
Vol 232 (2) ◽  
pp. 209-215 ◽  
Author(s):  
Małgorzata Dobrzyńska ◽  
Marek Lenarczyk ◽  
Antoni K. Gajewski
Keyword(s):  
Male Mice ◽  
X Ray ◽  
Lethal Mutations ◽  
Dominant Lethal ◽  
Dominant Lethal Mutations

scholarly journals Dominant lethal mutations induced in male mice by methyl methanesulphonate

Heredity ◽  
1964 ◽  
Vol 19 (2) ◽  
pp. 191-200 ◽  
Author(s):  
M Partington ◽  
A J Bateman
Keyword(s):  
Male Mice ◽  
Lethal Mutations ◽  
Dominant Lethal ◽  
Dominant Lethal Mutations

scholarly journals Induction of specific-locus and dominant lethal mutations in male mice by ifosfamide (Holoxan)

1998 ◽  
Vol 72 (3) ◽  
pp. 177-183 ◽  
Author(s):  
U. H. EHLING ◽  
J. FAVOR ◽  
A. NEUHÄUSER-KLAUS ◽  
I.-D. ADLER
Keyword(s):  
Germ Cell ◽  
Germ Cells ◽  
Genetic Risk ◽  
Male Mice ◽  
Induced Mutations ◽  
Lethal Mutations ◽  
Dominant Lethal ◽  
Cell Specificity ◽  
Dominant Lethal Mutations ◽  
Specific Locus

Ifosfamide induced dominant lethal mutations in spermatozoa of mice at doses of 200 and 300 mg/kg and in spermatids and spermatocytes at 600 mg/kg. The highest dose also induced specific-locus mutations in post-spermatogonial germ-cell stages of mice but not in spermatogonial stem cells. The nature of the induced mutations suggests they are intergenic. The spermatogenic specificity of ifosfamide in mouse germ cells is similar to that of the structurally related cytostatic drugs cyclophosphamide and trofosfamide. Due to the post-spermatogonial germ cell specificity of ifosfamide, the genetic risk is limited to a few weeks after exposure.

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