AbstractOver the last decades, we have witnessed an exponential increase in sequential computing performance, but since few years this progress is slowing down. This paper describes the current evolutions in technology and architecture that cause this slowdown, and lists the major research challenges that need to be tackled in the coming years to further continue this exponential performance growth. If the computing industry fails to solve these challenges soon, this will for the first time lead to a stop of the exponential performance growth, which might eventually impact the economic growth of western economies.