Solid phase synthesis of oligodeoxynucleoside phosphorodithioates by a phosphotriester method using a chemoselective coupling reagent

1996 ◽  
Vol 37 (44) ◽  
pp. 8041-8044 ◽  
Author(s):  
Jan Kehler ◽  
Ask Püschl ◽  
Otto Dahl
Keyword(s):  
Solid Phase Synthesis ◽  
Solid Phase ◽  
Phase Synthesis ◽  
Coupling Reagent ◽  
Phosphotriester Method

2-Iminothiolane as a Useful Coupling Reagent for Polyamine Solid-Phase Synthesis

Synlett ◽  
2008 ◽  
Vol 2008 (18) ◽  
pp. 2785-2790 ◽  
Author(s):  
Ute Schepers ◽  
Frank Hahn ◽  
Klaus Müllen
Keyword(s):  
Solid Phase Synthesis ◽  
Solid Phase ◽  
Phase Synthesis ◽  
Coupling Reagent

scholarly journals Search for New Aggregable Fragments of Human Insulin

Molecules ◽  
2019 ◽  
Vol 24 (8) ◽  
pp. 1600 ◽  
Author(s):  
Monika Swiontek ◽  
Justyna Fraczyk ◽  
Joanna Wasko ◽  
Agata Chaberska ◽  
Lukasz Pietrzak ◽  
...  
Keyword(s):  
Human Insulin ◽  
Solid Phase Synthesis ◽  
Solid Phase ◽  
Fibrous Structure ◽  
Aggregation Process ◽  
Phase Synthesis ◽  
Physiological Conditions ◽  
Entire Structure ◽  
Coupling Reagent ◽  
Over Time

In this study, three independent methods were used to identify short fragment of both chains of human insulin which are prone for aggregation. In addition, circular dichroism (CD) research was conducted to understand the progress of aggregation over time. The insulin fragments (deca- and pepta-peptides) were obtained by solid-phase synthesis using 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium toluene-4-sulfonate (DMT/NMM/TosO-) as a coupling reagent. Systematic studies allowed identification of the new fragments, expected to be engaged in triggering aggregation of the entire structure of human insulin under physiological conditions. It was found that the aggregation process occurs through various structural conformers and may favor the formation of a fibrous structure of aggregate.

2-Iminothiolane as a Coupling Reagent for Polyamine Solid-Phase Synthesis

Synfacts ◽  
2009 ◽  
Vol 2009 (03) ◽  
pp. 0341-0341
Author(s):  
U. Schepers ◽  
F. Hahn ◽  
K. Müllen
Keyword(s):  
Solid Phase Synthesis ◽  
Solid Phase ◽  
Phase Synthesis ◽  
Coupling Reagent
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