Selectivity of various opioid peptides towards delta-, kappa; and MU-opioid receptors mediating presynaptic inhibition of neurotransmitter release in the brain

Neuropeptides ◽  
1989 ◽  
Vol 14 (2) ◽  
pp. 99-104 ◽  
Author(s):  
A.H. Mulder ◽  
G. Wardeh ◽  
F. Hogenboom ◽  
A.L. Frankhuyzen
Keyword(s):  
Opioid Receptors ◽  
Opioid Peptides ◽  
Neurotransmitter Release ◽  
Presynaptic Inhibition ◽  
Mu Opioid Receptors ◽  
Mu Opioid ◽  
The Brain

Decrease of mu opioid receptors in the brain and in the hypothalamus of the aged male rat

Life Sciences ◽  
1987 ◽  
Vol 40 (4) ◽  
pp. 391-398 ◽  
Author(s):  
Flavio Piva ◽  
Roberto Maggi ◽  
Patrizia Limonta ◽  
Donatella Dondi ◽  
Luciano Martini
Keyword(s):  
Opioid Receptors ◽  
Male Rat ◽  
Mu Opioid Receptors ◽  
Mu Opioid ◽  
The Brain

Excessive sugar intake alters binding to dopamine and mu-opioid receptors in the brain

Neuroreport ◽  
2001 ◽  
Vol 12 (16) ◽  
pp. 3549-3552 ◽  
Author(s):  
C. Colantuoni ◽  
J. Schwenker ◽  
J. McCarthy ◽  
P. Rada ◽  
B. Ladenheim ◽  
...  
Keyword(s):  
Opioid Receptors ◽  
Mu Opioid Receptors ◽  
Mu Opioid ◽  
Sugar Intake ◽  
The Brain

scholarly journals Mu opioid receptors acutely regulate adenosine signaling in a thalamo-striatal circuit.

2021 ◽  
Author(s):  
Sweta Adhikary ◽  
William T Birdsong
Keyword(s):  
Opioid Receptors ◽  
Neurotransmitter Release ◽  
Energy Homeostasis ◽  
Prolonged Exposure ◽  
Cyclic Adenosine Monophosphate ◽  
Adenosine Monophosphate ◽  
Mu Opioid Receptors ◽  
Presynaptic Terminals ◽  
Mu Opioid ◽  
Adenosine Signaling

Endogenous adenosine plays a crucial role in maintaining energy homeostasis and adenosine levels are tightly regulated across neural circuits. In the dorsal medial striatum (DMS) adenosine inhibits neurotransmitter release, but the source and mechanism underlying its accumulation are largely unknown. Opioids also inhibit neurotransmitter release in the DMS and influences adenosine accumulation after prolonged exposure. However, how these two neurotransmitter systems interact acutely is also largely unknown. This study demonstrates that activation of mu opioid receptors (MORs), but not delta opioid receptors (DORs) or kappa opioid receptors (KORs), inhibits tonic activation of adenosine A1Rs via a cyclic adenosine monophosphate (cAMP) dependent mechanism in both male and female mice. Further, selectively knocking-out MORs from presynaptic terminals and postsynaptic medium spiny neurons (MSNs) revealed that activation of MORs on D1R positive MSNs, but not D2R positive MSNs, is necessary to inhibit tonic adenosine signaling on presynaptic terminals. Given the role of D1R positive MSNs in movement and motivated behaviors, these findings reveal a novel mechanism by which these neurons regulate their own synaptic inputs.

scholarly journals Endomorphin-2 and Endomorphin-1 Promote the Extracellular Amount of Accumbal Dopamine via Nonopioid and Mu-Opioid Receptors, Respectively

2005 ◽  
Vol 31 (2) ◽  
pp. 375-383 ◽  
Author(s):  
Hiroko Okutsu ◽  
Shu Watanabe ◽  
Ichiro Takahashi ◽  
Yuri Aono ◽  
Tadashi Saigusa ◽  
...  
Keyword(s):  
Opioid Receptors ◽  
Mu Opioid Receptors ◽  
Mu Opioid
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