Genotoxic effects of some organophosphorus pesticides II. In vivo chromosomal aberration bioassay in bone marrow cells in rat

1987 ◽  
Vol 188 (1) ◽  
pp. 45-51 ◽  
Author(s):  
P.K. Malhi ◽  
I.S. Grover
2015 ◽  
Vol 67 (2) ◽  
pp. 747-747
Author(s):  
E Editorial

This is a notice of retraction of the article: Fumagillin-induced chromosome aberrations in mouse bone-marrow cells, published in the Archives of Biological Sciences in 2010, Vol. 62, Issue 1. The Editor-in-Chief has been informed that this paper plagiarizes an earlier paper: Kulic M, Aleksic N, Stanimirovic Z, Ristic S, Medenica S. Examination of genotoxic effects of fumagillin in vivo. Genetika. 2009;41(3):329-38. The results presented in the article that is being retracted partially overlap with the results in the original article without appropriate justification, permission or crossreferencing. Further, Figs. 1 and 2 in the retracted article also appear in: Stanimirovic Z, Stevanovic J, Kulic M, Stojic V. Frequency of chromosomal aberrations in the evaluation of genotoxic potential of dicyclohexylamine (fumagillin) in vivo. Acta Veterinaria. 2006;56(4):353-66. and in Stanimirovic Z, Stevanovic J, Bajic V, Radovic I. Evaluation of genotoxic effects of fumagillin by cytogenetic tests in vivo. Mutat Res. 2007;628(1):1-10. These figures (in the retracted article) have been subsequently tampered with and therefore present falsified results. After confirmation of this fact, the Editor-in-Chief of the Archives of Biological Sciences has decided to retract the paper immediately. We apologize to the readers of the journal that it took so many years to notice this error and to retract the paper. We request readers of the journal to directly get in touch with the editorial office and the editors of the journal for similar cases in the future, so that they can be handled promptly. <br><br><font color="red"><b> Link to the retracted article <u><a href="http://dx.doi.org/10.2298/ABS1001047S">10.2298/ABS1001047S</a></b></u>


CYTOLOGIA ◽  
1999 ◽  
Vol 64 (3) ◽  
pp. 277-283 ◽  
Author(s):  
H. B. Ila ◽  
M. Topaktas

2009 ◽  
Vol 25 (7) ◽  
pp. 467-471 ◽  
Author(s):  
BN Mojidra ◽  
K. Archana ◽  
AK Gautam ◽  
Y. Verma ◽  
BC Lakkad ◽  
...  

Pan masala is commonly consumed in south-east Asian and other oriental countries as an alternate of tobacco chewing and smoking. Genotoxic potential of pan masala (pan masala plain and pan masala with tobacco known as gutkha) was evaluated employing chromosome aberration (CA) and micronucleus (MN) assay in vivo. Animals were exposed to three different doses (0.5%, 1.5% and 3%) of pan masala plain (PMP) and gutkha (PMT) through feed for a period of 6 months and micronucleus and chromosomal aberrations were studied in the bone marrow cells. Induction of mean micronuclei in polychromatic erythrocytes (MNPCE) and normochromatic erythrocyte (MNNCE) was higher in both types of pan masala treated groups with respect to control group. Both pan masala plain and gutkha treatment significantly induced the frequency of MNPCE and MNNCE in the bone marrow cells, indicating the genotoxic potential. Furthermore, slight decline in the ratio of polychromatic erythrocytes to normochromatic erythrocytes was also noticed, suggesting the cytotoxic potential even though the ratio was statistically non significant. A dose-dependent, significant increase in chromosome aberration was observed in both types of pan masala treated mice with respect to control. However, no significant difference in micronucleus and chromosomal aberration induction was noticed between two types of pan masala exposed (PMP and PMT) groups. Results suggest that both types of pan masala, i.e. plain and gutkha, have genotoxic potential.


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