Genotoxic effects of some systemic pesticides: In vivo chromosomal aberrations in bone marrow cells in rats

1988 ◽  
Vol 12 (2) ◽  
pp. 235-242 ◽  
Author(s):  
N. Adhikari ◽  
I. S. Graver
2015 ◽  
Vol 67 (2) ◽  
pp. 747-747
Author(s):  
E Editorial

This is a notice of retraction of the article: Fumagillin-induced chromosome aberrations in mouse bone-marrow cells, published in the Archives of Biological Sciences in 2010, Vol. 62, Issue 1. The Editor-in-Chief has been informed that this paper plagiarizes an earlier paper: Kulic M, Aleksic N, Stanimirovic Z, Ristic S, Medenica S. Examination of genotoxic effects of fumagillin in vivo. Genetika. 2009;41(3):329-38. The results presented in the article that is being retracted partially overlap with the results in the original article without appropriate justification, permission or crossreferencing. Further, Figs. 1 and 2 in the retracted article also appear in: Stanimirovic Z, Stevanovic J, Kulic M, Stojic V. Frequency of chromosomal aberrations in the evaluation of genotoxic potential of dicyclohexylamine (fumagillin) in vivo. Acta Veterinaria. 2006;56(4):353-66. and in Stanimirovic Z, Stevanovic J, Bajic V, Radovic I. Evaluation of genotoxic effects of fumagillin by cytogenetic tests in vivo. Mutat Res. 2007;628(1):1-10. These figures (in the retracted article) have been subsequently tampered with and therefore present falsified results. After confirmation of this fact, the Editor-in-Chief of the Archives of Biological Sciences has decided to retract the paper immediately. We apologize to the readers of the journal that it took so many years to notice this error and to retract the paper. We request readers of the journal to directly get in touch with the editorial office and the editors of the journal for similar cases in the future, so that they can be handled promptly. <br><br><font color="red"><b> Link to the retracted article <u><a href="http://dx.doi.org/10.2298/ABS1001047S">10.2298/ABS1001047S</a></b></u>


1999 ◽  
Vol 22 (3) ◽  
pp. 401-406 ◽  
Author(s):  
Regislaine V. Burim ◽  
Renata Canalle ◽  
João L. Callegari Lopes ◽  
Catarina S. Takahashi

Glaucolide B is a sesquiterpene lactone isolated from Vernonia eremophila Mart. (Vernonieae, Asteraceae) and has schistosomicidal, antimicrobial and analgesic activities. This study examined the cytotoxic and clastogenic activities of glaucolide B in human cultured lymphocytes and in bone marrow cells from BALB/c mice. The mitotic index (MI) and chromosomal aberrations were analyzed in both of the above systems, whereas sister chromatid exchanges (SCE) and the proliferation index (PI) were determined only in vitro. In human cultured lymphocytes, glaucolide B concentrations greater than 15 µg/ml of culture medium completely inhibited cell growth. At 4 µg/ml and 8 µg/ml of culture medium, glaucolide B significantly increased the frequency of chromosomal aberrations in lymphocytes and was also cytotoxic at concentrations ³8 µg/ml; there was no increase in the frequency of SCE. Glaucolide B (160-640 mg/kg) did not significantly increase the frequency of chromosomal aberrations in mouse bone marrow cells nor did it affect cell division. Since glaucolide B showed no clastogenic action on mammalian cells in vivo but was cytotoxic and clastogenic in vitro, caution is needed in its medicinal use.


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