Loss of heterozygosity for a chromosome 3 sequence presumably at 3p21 in small cell lung cancer

1987 ◽  
Vol 27 (2) ◽  
pp. 361-365 ◽  
Author(s):  
Hans Mooibroek ◽  
Jan Osinga ◽  
Pieter E. Postmus ◽  
Ben Carritt ◽  
Charles H.C.M. Buys
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Loss Of Heterozygosity ◽  
Cell Lung Cancer ◽  
Small Cell ◽  
Chromosome 3 ◽  
Small Cell Lung

Loss of Heterozygosity at 3p in Korean Non-Small Cell Lung Cancer

1998 ◽  
Vol 45 (5) ◽  
pp. 975
Author(s):  
Choon Taek Lee ◽  
Mi Hee Kim ◽  
Kyung Ho Park ◽  
Jong Ho Park ◽  
Hee Jong Baek ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Loss Of Heterozygosity ◽  
Cell Lung Cancer ◽  
Small Cell ◽  
Small Cell Lung

3p Abnormalities in Peripheral Lymphocytes in Small Cell Lung Cancer

2009 ◽  
Vol 95 (4) ◽  
pp. 535-537
Author(s):  
Yelda Tarkan-Argüden ◽  
Seniha Hacihanefioglu ◽  
Gül Öngen ◽  
Müzeyyen Erk ◽  
Asim Cenani
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Small Cell ◽  
Chromosome Abnormalities ◽  
Cancer Development ◽  
Banding Technique ◽  
Chromosome 3 ◽  
Small Cell Lung ◽  
Peripheral Lymphocytes

3p abnormalities are the most frequent chromosome abnormalities in small cell lung cancer (SCLC). To date these abnormalities have only been observed in cells derived from tumor tissues. It is thought that cancer-related chromosome abnormalities in peripheral lymphocytes could help to predict cancer development, prognosis, and future metastasis. We report clonal and nonclonal 3p abnormalities in the peripheral lymphocytes of two patients with SCLC. A standard T-lymphocyte culture method and GTL banding technique were applied to the samples, and various clonal and nonclonal chromosome 3 abnormalities, i.e., −3, del(3)(p24), del(3)(p21), del(3)(p11), del(3)(q22), inv(3)(p14q29), and inv(3)(q21q29) were observed. Efforts have been made to understand if there are cancer-related chromosome abnormalities in lymphocytes and the suitability of these abnormalities to predict cancer development or metastases. As far as we know, this is the first report on chromosome 3 abnormalities in lymphocytes. Since 3p abnormalities are specific for SCLC, it is important to show that these cancer-related abnormalities can be found in blood cells.

scholarly journals Loss of Heterozygosity of Chromosome 3p21 Is Associated with Mutant TP53 and Better Patient Survival in Non–Small-Cell Lung Cancer

2004 ◽  
Vol 64 (23) ◽  
pp. 8702-8707 ◽  
Author(s):  
Carmen J. Marsit ◽  
Masayuki Hasegawa ◽  
Tomoko Hirao ◽  
Duk-Hwan Kim ◽  
Kenneth Aldape ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Loss Of Heterozygosity ◽  
Cell Lung Cancer ◽  
Patient Survival ◽  
Small Cell ◽  
Small Cell Lung ◽  
Chromosome 3P21

LOSS OF HETEROZYGOSITY AT 5q21 IN NON-SMALL CELL LUNG CANCER: A FREQUENT EVENT BUT WITHOUT EVIDENCE OFAPC MUTATION

1996 ◽  
Vol 180 (1) ◽  
pp. 33-37 ◽  
Author(s):  
CINDY A. COOPER ◽  
VIVIEN J. BUBB ◽  
NICOLA SMITHSON ◽  
ROBERT L. CARTER ◽  
SARAH GLEDHILL ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Loss Of Heterozygosity ◽  
Cell Lung Cancer ◽  
Small Cell ◽  
Small Cell Lung ◽  
Frequent Event
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