In vitro protein-binding characteristics of delavirdine and its N-dealkylated metabolite

1996 ◽  
Vol 32 (2) ◽  
pp. 81-89 ◽  
Author(s):  
Alan J Chaput ◽  
Robin D'Ambrosio ◽  
Gene D Morse
Keyword(s):  
Protein Binding ◽  
Binding Characteristics ◽  
Vitro Protein

In vitro protein-binding characteristics of atevirdine and its N-dealkylated metabolite

1994 ◽  
Vol 25 (3-4) ◽  
pp. 193-200 ◽  
Author(s):  
Lisa M Rosser ◽  
Alice M O'Donnell ◽  
Kelly M Lee ◽  
Gene D Morse
Keyword(s):  
Protein Binding ◽  
Binding Characteristics ◽  
Vitro Protein

scholarly journals Divergent subcellular locations of HTLV-I tax and Int-6: A contrast between in vitro protein-protein binding and intracellular protein colocalization

1997 ◽  
Vol 4 (5) ◽  
pp. 229-234 ◽  
Author(s):  
Christine Neuveut ◽  
Dong-Yan Jin ◽  
Oliver J. Semmes ◽  
Francesca Diella ◽  
Robert Callahan ◽  
...  
Keyword(s):  
Protein Binding ◽  
Intracellular Protein ◽  
Vitro Protein

Determinants of Drug Removal by Continuous Hemofiltration

1994 ◽  
Vol 17 (7) ◽  
pp. 373-378 ◽  
Author(s):  
A.H. Lau ◽  
N.O. Kronfol
Keyword(s):  
Protein Binding ◽  
Plasma Proteins ◽  
Drug Transport ◽  
Continuous Hemofiltration ◽  
Membrane Interaction ◽  
Binding Characteristics ◽  
Molecular Weights ◽  
Polyacrylonitrile Membrane ◽  
Modest Effect

Continuous hemofiltration was conducted in vitro to identify parameters that affect drug transport across hemofilter membranes. The removal of seven drugs with different molecular weights and protein binding characteristics was assessed. Sieving coefficients were determined with both blood and saline using polysulfone, polyacrylonitrile and polyamide membranes. Drug sieving coefficients obtained with saline were generally higher than those obtained with blood. Molecular weights of the drugs did not correlate with the magnitude of drug sieving. Sieving coefficients in blood were also predicted from saline data assuming plasma protein binding is responsible for the reduced drug sieving with blood. For drugs that are highly protein bound, protein binding was the primary factor limiting drug sieving. Presence of plasma proteins also had a modest effect on sieving of other drugs. The sieving coefficients obtained with the polyacrylonitrile membrane tend to be different from those obtained with the other hemofilters. Drug-membrane interaction may contribute to the differences in drug transport among the membranes.

In Vitro Protein Binding of Diclofenac Sodium in Plasma and Synovial Fluid

1987 ◽  
Vol 76 (2) ◽  
pp. 105-108 ◽  
Author(s):  
Keith K.H. Chan ◽  
Kunjbala H. Vyas ◽  
Kenneth D. Brandt
Keyword(s):  
Synovial Fluid ◽  
Protein Binding ◽  
Diclofenac Sodium ◽  
Vitro Protein

In vitro protein binding of propafenone in normal and uraemic human sera

1989 ◽  
Vol 36 (5) ◽  
pp. 495-499 ◽  
Author(s):  
G. L. -Y. Chan ◽  
J. E. Axelson ◽  
J. D. E. Price ◽  
K. M. McErlane ◽  
C. R. Kerr
Keyword(s):  
Protein Binding ◽  
Human Sera ◽  
Vitro Protein

In vitro protein binding interaction studies involving cefixime

1988 ◽  
Vol 9 (3) ◽  
pp. 315-320 ◽  
Author(s):  
Meir Bialer ◽  
Wen Hui Wu ◽  
Robert D. Faulkner ◽  
B. Michael Silber ◽  
Avraham Yacobi
Keyword(s):  
Protein Binding ◽  
Binding Interaction ◽  
Interaction Studies ◽  
Vitro Protein
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